ID Y848_MYCTU Reviewed; 372 AA.
AC Q79FV4; L0T531;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 01-MAY-2013, entry version 59.
DE RecName: Full=Uncharacterized pyridoxal phosphate-dependent protein CysK2;
GN Name=cysK2; OrderedLocusNames=Rv0848;
OS Mycobacterium tuberculosis.
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
RA Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
RA Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
RA Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
RA Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
RA Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
RA Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the
RT complete genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=12368430;
RA Camus J.-C., Pryor M.J., Medigue C., Cole S.T.;
RT "Re-annotation of the genome sequence of Mycobacterium tuberculosis
RT H37Rv.";
RL Microbiology 148:2967-2973(2002).
RN [3]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium
RT tuberculosis through an interactome, reactome and genome-scale
RT structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
CC -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC -!- SIMILARITY: Belongs to the cysteine synthase/cystathionine beta-
CC synthase family.
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DR EMBL; BX842574; CAE55331.1; -; Genomic_DNA.
DR EMBL; AL123456; CCP43596.1; -; Genomic_DNA.
DR PIR; H70813; H70813.
DR RefSeq; YP_006514199.1; NC_018143.1.
DR RefSeq; YP_177762.1; NC_000962.3.
DR HSSP; Q9WZD3; 1O58.
DR ProteinModelPortal; Q79FV4; -.
DR SMR; Q79FV4; 31-323.
DR STRING; 83332.Rv0848; -.
DR GeneID; 13318750; -.
DR GeneID; 885545; -.
DR KEGG; mtu:Rv0848; -.
DR KEGG; mtv:RVBD_0848; -.
DR PATRIC; 18150413; VBIMycTub87468_0949.
DR TubercuList; Rv0848; -.
DR eggNOG; COG0031; -.
DR HOGENOM; HOG000217394; -.
DR KO; K01738; -.
DR OMA; GSWCPDQ; -.
DR ProtClustDB; CLSK918316; -.
DR Reactome; REACT_27295; Mycobacterium tuberculosis biological processes.
DR GO; GO:0005618; C:cell wall; IDA:MTBBASE.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0004124; F:cysteine synthase activity; TAS:Reactome.
DR GO; GO:0006535; P:cysteine biosynthetic process from serine; TAS:Reactome.
DR InterPro; IPR001926; Trp_syn_b_sub_like_PLP_eny_SF.
DR Pfam; PF00291; PALP; 1.
DR SUPFAM; SSF53686; PyrdxlP-dep_enz_bsu; 1.
DR PROSITE; PS00901; CYS_SYNTHASE; FALSE_NEG.
PE 3: Inferred from homology;
KW Complete proteome; Pyridoxal phosphate; Reference proteome.
FT CHAIN 1 372 Uncharacterized pyridoxal phosphate-
FT dependent protein CysK2.
FT /FTId=PRO_0000401201.
FT REGION 201 205 Pyridoxal phosphate binding (By
FT similarity).
FT BINDING 288 288 Pyridoxal phosphate (By similarity).
FT MOD_RES 65 65 N6-(pyridoxal phosphate)lysine (By
FT similarity).
SQ SEQUENCE 372 AA; 40118 MW; 927386BE1DF5FB6C CRC64;
MRSRQTRDRY RLLPEGYQVT PGRNRHPGTM VGNTPVLWIP ELSGTSDPDR GFWAKLEGFN
PGGMKDRPAL YMVECARARG DIAPGAAIVE STGGTLGLGL ALAGKVYRHP VTLVTDPGLE
PIIARMLTAY GAGVDMVTQP HPVGGWQQAR KDRVAQLMAE YPGAWNPNQY GNPDNVGAYR
SLALELVAQL GRIDVLVCSV GTGGHSAGVA RVLREFNPDM RLIGVDTIGS TIFGQPASNR
LMRGLGSSIY PRNVDYRAFD EVHWVAPPEA VWACRSLAAT HYASGGWSVG AVALVAGWAA
RNLPADTTIA AVFPDGPQRY FDTIYNDAYC NEHELLGGQP PTEPDEIASP LDAVVTRWTR
STTVIDPTQV VS
//
