ID Q79RD8_FRATL Unreviewed; 578 AA.
AC Q79RD8;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=3-beta hydroxysteroid dehydrogenase/isomerase family protein {ECO:0000313|EMBL:AJI70797.1};
DE SubName: Full=Sugar dehydratase {ECO:0000313|EMBL:AAS60264.1};
GN Name=wbtA {ECO:0000313|EMBL:AAS60264.1};
GN ORFNames=CH69_1420 {ECO:0000313|EMBL:AJI70797.1};
OS Francisella tularensis subsp. tularensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=119856 {ECO:0000313|EMBL:AAS60264.1};
RN [1] {ECO:0000313|EMBL:AAS60264.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Schu S4 {ECO:0000313|EMBL:AAS60264.1};
RA Prior J.L., Prior R.G., Hitchen P.G., Diaper H., Dell A., Titball R.W.;
RT "Characterization of the O-antigen gene cluster and structural analysis of
RT the O-antigen of a type A strain of Francisella tularensis.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAS60264.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Schu S4 {ECO:0000313|EMBL:AAS60264.1};
RX PubMed=12517824; DOI=10.1128/JCM.41.1.50-57.2003;
RA Thomas R., Johansson A., Neeson B., Isherwood K., Sjostedt A., Ellis J.,
RA Titball R.W.;
RT "Discrimination of human pathogenic subspecies of Francisella tularensis by
RT using restriction fragment length polymorphism.";
RL J. Clin. Microbiol. 41:50-57(2003).
RN [3] {ECO:0000313|EMBL:AAS60264.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Schu S4 {ECO:0000313|EMBL:AAS60264.1};
RA Prior J.L., Prior R.G., Larsson P., Titball R.W., Forsman M.,
RA Andersson S.G.E.;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AJI70797.1, ECO:0000313|Proteomes:UP000031924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Scherm {ECO:0000313|EMBL:AJI70797.1,
RC ECO:0000313|Proteomes:UP000031924};
RX PubMed=25931589;
RA Johnson S.L., Daligault H.E., Davenport K.W., Coyne S.R., Frey K.G.,
RA Koroleva G.I., Broomall S.M., Bishop-Lilly K.A., Bruce D.C., Chertkov O.,
RA Freitas T., Jaissle J., Ladner J.T., Rosenzweig C.N., Gibbons H.S.,
RA Palacios G.F., Redden C.L., Xu Y., Minogue T.D., Chain P.S.;
RT "Genome sequencing of 18 francisella strains to aid in assay development
RT and testing.";
RL Genome Announc. 3:0-0(2015).
CC -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC {ECO:0000256|ARBA:ARBA00007430}.
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DR EMBL; AY101577; AAS60264.1; -; Genomic_DNA.
DR EMBL; CP010287; AJI70797.1; -; Genomic_DNA.
DR RefSeq; WP_003022302.1; NZ_JACVMH010000012.1.
DR AlphaFoldDB; Q79RD8; -.
DR DNASU; 3191939; -.
DR OMA; EIIIAMP; -.
DR Proteomes; UP000031924; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003869; Polysac_CapD-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR Pfam; PF13727; CoA_binding_3; 1.
DR Pfam; PF02719; Polysacc_synt_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:AJI70797.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 264..536
FT /note="Polysaccharide biosynthesis protein CapD-like"
FT /evidence="ECO:0000259|Pfam:PF02719"
SQ SEQUENCE 578 AA; 65724 MW; 4DEEF7B0C27FB883 CRC64;
MSFYDNRTLN FVVIIVLTII TVNWTFYIFK QDVNLHFLLA LVLLRCLSSF LLLRDYMASW
RKSTQKTFLR KAFINLPVFF IVALFFYGKV TFSLIFSEFL FYVFLISLSV YFYWYLMNRG
SVDKSKTAVI YGAGAAGTKI AQELASAGYR IKCFVDDNET LQKRSIDSKK VLSKAELTKL
LLSSRFDLLV IALPRNANQV VKNIYKEFEK DFNQIRIMPP LEEILQDENF MSQLKPVSLY
DLLARDTKSL DKESISNFIK NKVVLVTGAG GSIGSEIVHQ CIKYQAKELI LVDHSEFNLY
KITEECSHFN INSVLCSVCD RKALAEVFQK YTPNIVFHAA AYKHVPLVEE NISRAIRNNI
LGTKNAIDLA IEAGVESFIL ISTDKAVRPT NVMGATKRVC ELYLQNVDPK NTKLAAVRFG
NVLGSSGSVI PKFEEQIRKG GPVTVTHPEI TRYFMLIPEA CELVLQAGAI AKNSEVFVLD
MGQPVKIIDL AKQFIRLSGR GDIDIKIVGL RPGEKLYEEL LIEEDDVSTD YKDIFIGRRT
FYDINTLNQD IESLIKDDVD QLVILKKIVP EFEHRLNG
//
