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Database: UniProt
Entry: Q7A3U5
LinkDB: Q7A3U5
Original site: Q7A3U5 
ID   NREC_STAAN              Reviewed;         217 AA.
AC   Q7A3U5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   01-OCT-2014, entry version 83.
DE   RecName: Full=Oxygen regulatory protein NreC;
DE   AltName: Full=Nitrogen regulation protein C;
GN   Name=nreC; OrderedLocusNames=SA2179;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/S0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I.,
RA   Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K.,
RA   Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M.,
RA   Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M.,
RA   Ogasawara N., Hayashi H., Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus
RT   aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Member of the two-component regulatory system NreB/NreC
CC       involved in the control of dissimilatory nitrate/nitrite reduction
CC       in response to oxygen. Phosphorylated NreC binds to a GC-rich
CC       palindromic sequence at the promoters of the nitrate (narGHJI) and
CC       nitrite (nir) reductase operons, as well as the putative nitrate
CC       transporter gene narT, and activates their expression (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by NreB. {ECO:0000250}.
CC   -!- SIMILARITY: Contains 1 HTH luxR-type DNA-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00411}.
CC   -!- SIMILARITY: Contains 1 response regulatory domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00169}.
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DR   EMBL; BA000018; BAB43481.1; -; Genomic_DNA.
DR   PIR; H90039; H90039.
DR   RefSeq; NP_375502.1; NC_002745.2.
DR   ProteinModelPortal; Q7A3U5; -.
DR   SMR; Q7A3U5; 1-216.
DR   STRING; 158879.SA2179; -.
DR   PRIDE; Q7A3U5; -.
DR   EnsemblBacteria; BAB43481; BAB43481; BAB43481.
DR   GeneID; 1125107; -.
DR   KEGG; sau:SA2179; -.
DR   PATRIC; 19576892; VBIStaAur116463_2364.
DR   eggNOG; COG2197; -.
DR   HOGENOM; HOG000034813; -.
DR   KO; K07696; -.
DR   OMA; YQEDMEV; -.
DR   OrthoDB; EOG69GZGV; -.
DR   BioCyc; SAUR158879:GJCB-2339-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW   Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN         1    217       Oxygen regulatory protein NreC.
FT                                /FTId=PRO_0000349351.
FT   DOMAIN        2    119       Response regulatory.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
FT   DOMAIN      148    213       HTH luxR-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00411}.
FT   DNA_BIND    172    191       H-T-H motif. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00411}.
FT   MOD_RES      53     53       4-aspartylphosphate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
SQ   SEQUENCE   217 AA;  24368 MW;  DDF2969C5B277320 CRC64;
     MKIVIADDHA VVRTGFSMIL NYQNDMEVVA TAADGVEAYQ KVMEYKPDVL LMDLSMPPGE
     SGLIATSKIA DSFPETKILI LTMFDDEEYL FHVLRNGAKG YILKNAPDEQ LLLAIRTVYK
     GETYVDMKLT TSLVNEFVSN SNQDTANTTD PFKILSKREL EILPLIAKGY GNKEIAEKLF
     VSVKTVEAHK THIMTKLGLK SKPELVEYAL KKKLLEF
//
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