ID NREC_STAAN Reviewed; 217 AA.
AC Q7A3U5;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 29-MAY-2013, entry version 76.
DE RecName: Full=Oxygen regulatory protein NreC;
DE AltName: Full=Nitrogen regulation protein C;
GN Name=nreC; OrderedLocusNames=SA2179;
OS Staphylococcus aureus (strain N315).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX NCBI_TaxID=158879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N315;
RX PubMed=11418146; DOI=10.1016/S0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I.,
RA Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K.,
RA Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M.,
RA Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M.,
RA Ogasawara N., Hayashi H., Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus
RT aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Member of the two-component regulatory system NreB/NreC
CC involved in the control of dissimilatory nitrate/nitrite reduction
CC in response to oxygen. Phosphorylated NreC binds to a GC-rich
CC palindromic sequence at the promoters of the nitrate (narGHJI) and
CC nitrite (nir) reductase operons, as well as the putative nitrate
CC transporter gene narT, and activates their expression (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC -!- PTM: Phosphorylated by NreB (By similarity).
CC -!- SIMILARITY: Contains 1 HTH luxR-type DNA-binding domain.
CC -!- SIMILARITY: Contains 1 response regulatory domain.
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DR EMBL; BA000018; BAB43481.1; -; Genomic_DNA.
DR PIR; H90039; H90039.
DR RefSeq; NP_375502.1; NC_002745.2.
DR ProteinModelPortal; Q7A3U5; -.
DR SMR; Q7A3U5; 1-215.
DR STRING; 158879.SA2179; -.
DR PRIDE; Q7A3U5; -.
DR EnsemblBacteria; BAB43481; BAB43481; BAB43481.
DR GeneID; 1125107; -.
DR KEGG; sau:SA2179; -.
DR PATRIC; 19576892; VBIStaAur116463_2364.
DR eggNOG; COG2197; -.
DR HOGENOM; HOG000034813; -.
DR KO; K07696; -.
DR OMA; FKEADWI; -.
DR ProtClustDB; CLSK885949; -.
DR BioCyc; SAUR158879:GJCB-2339-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:GOC.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46894; Bipartite_resp_reg_C-effector; 1.
DR SUPFAM; SSF52172; CheY_like; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1 217 Oxygen regulatory protein NreC.
FT /FTId=PRO_0000349351.
FT DOMAIN 2 119 Response regulatory.
FT DOMAIN 148 213 HTH luxR-type.
FT DNA_BIND 172 191 H-T-H motif (By similarity).
FT MOD_RES 53 53 4-aspartylphosphate (By similarity).
SQ SEQUENCE 217 AA; 24368 MW; DDF2969C5B277320 CRC64;
MKIVIADDHA VVRTGFSMIL NYQNDMEVVA TAADGVEAYQ KVMEYKPDVL LMDLSMPPGE
SGLIATSKIA DSFPETKILI LTMFDDEEYL FHVLRNGAKG YILKNAPDEQ LLLAIRTVYK
GETYVDMKLT TSLVNEFVSN SNQDTANTTD PFKILSKREL EILPLIAKGY GNKEIAEKLF
VSVKTVEAHK THIMTKLGLK SKPELVEYAL KKKLLEF
//
