ID   Q7B6G7_STRHY            Unreviewed;       449 AA.
AC   Q7B6G7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=Crotonyl-CoA reductase {ECO:0000313|EMBL:AAR32675.1};
OS   Streptomyces hygroscopicus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
OX   NCBI_TaxID=1912 {ECO:0000313|EMBL:AAR32675.1};
RN   [1] {ECO:0000313|EMBL:AAR32675.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=17997 {ECO:0000313|EMBL:AAR32675.1};
RA   Gao Q., Wang Y.;
RT   "Identification and analysis of two separate AHBA biosynthetic gene
RT   clusters in Streptomyces hygroscopicus 17997.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
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DR   EMBL; AF506520; AAR32675.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q7B6G7; -.
DR   GO; GO:0043880; F:crotonyl-CoA reductase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR010085; Crot_CoA_red.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   NCBIfam; TIGR01751; crot-CoA-red; 1.
DR   PANTHER; PTHR44154; QUINONE OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR44154:SF1; QUINONE OXIDOREDUCTASE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   4: Predicted;
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          43..409
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
FT   REGION          421..449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   449 AA;  48349 MW;  456E60B19B41B717 CRC64;
     MSRAVLDGAS ATEIEAAPVP ATYLALHLRA EDTDMFKGVA DKDVRKSLRL GQVPMPELAP
     DEVLVAVMAS SINYNTVWSA MFEPIPTFHF LKQNARQGGW AARHDQPYHV LGSDCSAVVV
     RVGTGVRRWK PGDHVTVHPV HVDDQQPETH GDGMLGSEQR AWGFETNFGA LAEYGIVRST
     QLLPKPAHLT WEEAAVNPLC ASTAYRMLVS DRGAHMKQGD IVLIWGASGG LGSYAIQFVK
     NGGGIPVAVV SSAQKEAAVR ALGCDLVINR TELGITDEMA DDPRLVLETG RKLAKLVVEK
     AGREPDIVFE HTGRVTFGLS VIVARRGGTV VTCGSSSGYL HTFDNRYLWM KLKKIVGSHG
     ANYEEQQATN RLFESGAVVP AMSAVYPLAA GAEACRIVQT SRQVGKVAVL CMAPEPGLGV
     TDPELRGRIG EDRLNPLRGL TAGPDSREL
//