ID   Q7BKK8_UREPR            Unreviewed;        70 AA.
AC   Q7BKK8;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE            EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
DE   Flags: Fragment;
GN   Name=folA {ECO:0000313|EMBL:AAK58675.1};
OS   Ureaplasma parvum serovar 14.
OC   Bacteria; Mycoplasmatota; Mycoplasmoidales; Mycoplasmoidaceae; Ureaplasma.
OX   NCBI_TaxID=95668 {ECO:0000313|EMBL:AAK58675.1};
RN   [1] {ECO:0000313|EMBL:AAK58675.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 33697 {ECO:0000313|EMBL:AAK58675.1};
RX   PubMed=15388749; DOI=10.1099/ijs.0.63073-0;
RA   Kong F., Gilbert G.L.;
RT   "Postgenomic taxonomy of human ureaplasmas - a case study based on multiple
RT   gene sequences.";
RL   Int. J. Syst. Evol. Microbiol. 54:1815-1821(2004).
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC       tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00004903}.
CC   -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC       {ECO:0000256|ARBA:ARBA00009539}.
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DR   EMBL; AF272630; AAK58675.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q7BKK8; -.
DR   UniPathway; UPA00077; UER00158.
DR   GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00209; DHFR; 1.
DR   Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR   InterPro; IPR012259; DHFR.
DR   InterPro; IPR024072; DHFR-like_dom_sf.
DR   InterPro; IPR001796; DHFR_dom.
DR   PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF00186; DHFR_1; 1.
DR   PRINTS; PR00070; DHFR.
DR   SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR   PROSITE; PS51330; DHFR_2; 1.
PE   3: Inferred from homology;
FT   DOMAIN          1..70
FT                   /note="DHFR"
FT                   /evidence="ECO:0000259|PROSITE:PS51330"
FT   NON_TER         70
FT                   /evidence="ECO:0000313|EMBL:AAK58675.1"
SQ   SEQUENCE   70 AA;  8255 MW;  8AD5C893953D39D3 CRC64;
     MLKLIWCQTL NGGISKNNKL PWYIKEELDH FYKTTKNHKI IMGKNTFDSL DQKPLNNRTN
     IIFSSIMQTP
//