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Database: UniProt
Entry: Q7BPB1_KLEPN
LinkDB: Q7BPB1_KLEPN
Original site: Q7BPB1_KLEPN 
ID   Q7BPB1_KLEPN            Unreviewed;       262 AA.
AC   Q7BPB1;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 102.
DE   RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252};
DE            EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126};
GN   Name=aadA4 {ECO:0000313|EMBL:AAF07905.1};
GN   Synonyms=aadA {ECO:0000313|EMBL:AJS10217.1}, aadA5
GN   {ECO:0000313|EMBL:AAF64679.1}, ant1 {ECO:0000313|EMBL:SSK63669.1}, ntp
GN   {ECO:0000313|EMBL:ADV78525.1};
GN   ORFNames=GJJ08_027375 {ECO:0000313|EMBL:QOU54720.1}, pKF140-058
GN   {ECO:0000313|EMBL:ADD63541.1}, pkp469IL_0360
GN   {ECO:0000313|EMBL:AGP03338.1}, SAMEA4364603_05346
GN   {ECO:0000313|EMBL:SSK63669.1};
OS   Klebsiella pneumoniae.
OG   Plasmid pKF3-140 {ECO:0000313|EMBL:ADD63541.1},
OG   Plasmid pKP09085 {ECO:0000313|EMBL:AHG55700.1},
OG   Plasmid pKP12226 {ECO:0000313|EMBL:AJS10217.1},
OG   Plasmid pkp469IL {ECO:0000313|EMBL:AGP03338.1}, and
OG   Plasmid unnamed2 {ECO:0000313|EMBL:QOU54720.1,
OG   ECO:0000313|Proteomes:UP000439817}.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573 {ECO:0000313|EMBL:AAF07905.1};
RN   [1] {ECO:0000313|EMBL:AAF07905.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KpB35 {ECO:0000313|EMBL:AAF07905.1};
RA   Kim J., Cho D.T., Seol S.Y., Lee J.C., Yoon J.J.;
RT   "Characterization of novel two gene cassettes, dhfrXVII and aadA4.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAF64679.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11062188; DOI=10.1093/jac/46.5.703;
RA   Naas T., Benaoudia F., Massuard S., Nordmann P.;
RT   "Integron-located VEB-1 extended-spectrum beta-lactamase gene in a Proteus
RT   mirabilis clinical isolate from Vietnam.";
RL   J. Antimicrob. Chemother. 46:703-711(2000).
RN   [3] {ECO:0000313|EMBL:AAF64679.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Naas T.P., Benaoudia F., Massuard S., Nordmann P.;
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AAF64679.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Naas T., Benaoudia F., Massuard S., Nordmann P.;
RT   "Characterization of two novel gene cassettes, dfr17 and aadA5 from
RT   Klebsiella pneumoniae.";
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:AAX98158.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Gu B., Tong M., Liu G.;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:ACX50268.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=S-56 {ECO:0000313|EMBL:ACX50268.1};
RA   Pryamchuk S.D., Fursova N.K., Abaev I.V., Pecherskikh E.I., Shishkova N.A.,
RA   Korobova O.V.;
RT   "Escherichia coli variable region of class 1 integron containing dfrA17 and
RT   aadA5 cassettes.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:ACY68995.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NF200116 {ECO:0000313|EMBL:ADF59114.1}, NF805502
RC   {ECO:0000313|EMBL:ADF59094.1}, NF806155 {ECO:0000313|EMBL:ADF59092.1},
RC   NF811834 {ECO:0000313|EMBL:ACY68995.1}, NF901054
RC   {ECO:0000313|EMBL:ACY79418.1}, NF902382 {ECO:0000313|EMBL:ADF59102.1},
RC   and NF904341 {ECO:0000313|EMBL:ADF59133.1};
RA   Wang F., Rui Y.;
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:ADD63541.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KF3 {ECO:0000313|EMBL:ADD63541.1};
RC   PLASMID=pKF3-140 {ECO:0000313|EMBL:ADD63541.1};
RX   PubMed=20405037;
RA   Zhao F., Bai J., Wu J., Liu J., Zhou M., Xia S., Wang S., Yao X., Yi H.,
RA   Lin M., Gao S., Zhou T., Xu Z., Niu Y., Bao Q.;
RT   "Sequencing and genetic variation of multidrug resistance plasmids in
RT   Klebsiella pneumoniae.";
RL   PLoS ONE 5:0-E10141(2010).
RN   [9] {ECO:0000313|EMBL:ADD97825.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Kp171 {ECO:0000313|EMBL:ADD97825.1};
RA   Santos C., Caetano T., Ferreira S., Mendo S.;
RT   "Class 1 integrons present in hospital environment.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:ADV78525.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DF12SA {ECO:0000313|EMBL:ADV78525.1};
RA   Shahi S.K., Singh V.K., Kumar A.;
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:AFM57741.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KP125 {ECO:0000313|EMBL:AFM57741.1};
RX   PubMed=24098729;
RA   Li B., Hu Y., Wang Q., Yi Y., Woo P.C., Jing H., Zhu B., Liu C.H.;
RT   "Structural Diversity of Class 1 Integrons and Their Associated Gene
RT   Cassettes in Klebsiella pneumoniae Isolates from a Hospital in China.";
RL   PLoS ONE 8:E75805-E75805(2013).
RN   [12] {ECO:0000313|EMBL:AGP03338.1}
RP   NUCLEOTIDE SEQUENCE.
RC   PLASMID=pkp469IL {ECO:0000313|EMBL:AGP03338.1};
RA   Chmelnitsky I., Shklyar M., Leavitt A., Sadovsky E., Navon-Venezia S.,
RA   Edgar R., Carmeli Y.;
RT   "KPC-2 encoding plasmids from Enterobacteriaceae in Israel.";
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:AHK14455.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=B-811K {ECO:0000313|EMBL:AHK14455.1};
RA   Astashkin E.I., Fursova N.K., Kartsev N.N.;
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:AHG55700.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ST48 {ECO:0000313|EMBL:AHG55700.1};
RC   PLASMID=pKP09085 {ECO:0000313|EMBL:AHG55700.1};
RX   PubMed=24257316; DOI=10.1093/jac/dkt464;
RA   Shin J., Soo Ko K.;
RT   "Single origin of three plasmids bearing blaCTX-M-15 from different
RT   Klebsiella pneumoniae clones.";
RL   J. Antimicrob. Chemother. 69:969-972(2014).
RN   [15] {ECO:0000313|EMBL:AJS10217.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ST11 {ECO:0000313|EMBL:AJS10217.1};
RC   PLASMID=pKP12226 {ECO:0000313|EMBL:AJS10217.1};
RX   PubMed=26195513; DOI=10.1128/AAC.00265-15;
RA   Shin J., Ko K.S.;
RT   "A Plasmid Bearing the blaCTX-M-15 Gene and Phage P1-Like Sequences from a
RT   Sequence Type 11 Klebsiella pneumoniae Isolate.";
RL   Antimicrob. Agents Chemother. 59:6608-6610(2015).
RN   [16] {ECO:0000313|EMBL:AKL72213.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NF130174 {ECO:0000313|EMBL:AKL72213.1};
RA   Lu W., Cheng C., Rui Y.;
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:SSK63669.1, ECO:0000313|Proteomes:UP000252603}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4300STDY6470422 {ECO:0000313|EMBL:SSK63669.1,
RC   ECO:0000313|Proteomes:UP000252603};
RG   Pathogen Informatics;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:QOU54720.1, ECO:0000313|Proteomes:UP000439817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CriePir120 {ECO:0000313|EMBL:QOU54720.1,
RC   ECO:0000313|Proteomes:UP000439817};
RC   PLASMID=unnamed2 {ECO:0000313|EMBL:QOU54720.1,
RC   ECO:0000313|Proteomes:UP000439817};
RX   PubMed=32429555;
RA   Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA   Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.;
RT   "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence
RT   Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella
RT   pneumoniae Isolates.";
RL   Antibiotics 9:E261-E261(2020).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC         Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC         Evidence={ECO:0000256|ARBA:ARBA00035070};
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DR   EMBL; AF180469; AAF07905.1; -; Genomic_DNA.
DR   EMBL; AF220757; AAF64679.1; -; Genomic_DNA.
DR   EMBL; AY994155; AAX98158.1; -; Genomic_DNA.
DR   EMBL; GQ896493; ACX50268.1; -; Genomic_DNA.
DR   EMBL; GU120473; ACY68995.1; -; Genomic_DNA.
DR   EMBL; GU129910; ACY79418.1; -; Genomic_DNA.
DR   EMBL; FJ876827; ADD63541.1; -; Genomic_DNA.
DR   EMBL; GU590935; ADD97825.1; -; Genomic_DNA.
DR   EMBL; GU944737; ADF59092.1; -; Genomic_DNA.
DR   EMBL; GU944738; ADF59094.1; -; Genomic_DNA.
DR   EMBL; GU944742; ADF59102.1; -; Genomic_DNA.
DR   EMBL; GU944748; ADF59114.1; -; Genomic_DNA.
DR   EMBL; GU944756; ADF59133.1; -; Genomic_DNA.
DR   EMBL; HQ114261; ADV78525.1; -; Genomic_DNA.
DR   EMBL; JQ823009; AFM57741.1; -; Genomic_DNA.
DR   EMBL; KF181262; AGP03338.1; -; Genomic_DNA.
DR   EMBL; KF719970; AHG55700.1; -; Genomic_DNA.
DR   EMBL; KF952266; AHK14455.1; -; Genomic_DNA.
DR   EMBL; KP453775; AJS10217.1; -; Genomic_DNA.
DR   EMBL; KP642030; AKL72213.1; -; Genomic_DNA.
DR   EMBL; CP063010; QOU54720.1; -; Genomic_DNA.
DR   EMBL; UFEU01000036; SSK63669.1; -; Genomic_DNA.
DR   RefSeq; WP_000503573.1; NZ_WUKO01000090.1.
DR   RefSeq; YP_003517587.1; NC_013951.1.
DR   RefSeq; YP_008999099.1; NC_023332.1.
DR   AlphaFoldDB; Q7BPB1; -.
DR   SMR; Q7BPB1; -.
DR   Proteomes; UP000252603; Unassembled WGS sequence.
DR   Proteomes; UP000439817; Plasmid unnamed2.
DR   GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd05403; NT_KNTase_like; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR025184; AadA_C.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   Pfam; PF13427; AadA_C; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE   4: Predicted;
KW   Nucleotidyltransferase {ECO:0000313|EMBL:AAF64679.1};
KW   Plasmid {ECO:0000313|EMBL:ADD63541.1};
KW   Transferase {ECO:0000313|EMBL:AAF64679.1}.
FT   DOMAIN          29..59
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          153..255
FT                   /note="Adenylyltransferase AadA C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13427"
SQ   SEQUENCE   262 AA;  29042 MW;  94DD4B1AD7941B1C CRC64;
     MGEFFPAQVF KQLSHARAVI ERHLAATLDT IHLFGSAIDG GLKPDSDIDL LVTVSAAPND
     SLRQALMLDL LKVSSPPGDG GTWRPLELTV VARSEVVPWR YPARRELQFG EWLRHDILSG
     TFEPAVLDHD LAILLTKARQ HSLALLGPSA ATFFEPVPKE HFSKALFDTI AQWNAESDWK
     GDERNVVLAL ARIWYSASTG LIAPKDVAAA WVSERLPAEH RPLICKARAA YLGSEDDDLA
     MRVEETAAFV RYAKATIERI LR
//
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