ID Q7D5R3_MYCTO Unreviewed; 992 AA.
AC Q7D5R3;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Sulfatase family protein {ECO:0000313|EMBL:AAK47741.1};
GN OrderedLocusNames=MT3398 {ECO:0000313|EMBL:AAK47741.1};
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331 {ECO:0000313|EMBL:AAK47741.1, ECO:0000313|Proteomes:UP000001020};
RN [1] {ECO:0000313|EMBL:AAK47741.1, ECO:0000313|Proteomes:UP000001020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh {ECO:0000313|Proteomes:UP000001020};
RX PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J., DeBoy R., Dodson R., Gwinn M., Haft D., Hickey E.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M., Salzberg S.L.,
RA Delcher A., Utterback T., Weidman J., Khouri H., Gill J., Mikula A.,
RA Bishai W., Jacobs Jr W.R.Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; AE000516; AAK47741.1; -; Genomic_DNA.
DR AlphaFoldDB; Q7D5R3; -.
DR SMR; Q7D5R3; -.
DR KEGG; mtc:MT3398; -.
DR HOGENOM; CLU_006332_11_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd16025; PAS_like; 1.
DR Gene3D; 3.30.1120.10; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR009200; DUF1269_membrane.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR42693; ARYLSULFATASE FAMILY MEMBER; 1.
DR PANTHER; PTHR42693:SF43; BLL2667 PROTEIN; 1.
DR Pfam; PF06897; DUF1269; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001020}.
FT DOMAIN 234..656
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
SQ SEQUENCE 992 AA; 108107 MW; 617474E0DC16416D CRC64;
MLRCQHGQPR PIAGRDTHIG SFVMSEDNAL VLVAGYQDLD SARHDFQTLV DAAKDKSIPL
QGAVLIGKDA EGSPVLVDTG NRLGRRGAAW GAGVGLAIGL FSPALLASAA LGAATGALAG
TFAHHRIKTG LADKIGQALA AGRAVVIAVT EAQGRLEAGQ ALASSPMKSV AELSRSTLRS
LGAALREAMG KFNPDRTRLP LPQRRFGGVV GRTMAESVGD WSIVPGPFPP DDAPNVLIVL
IDDAGFGGPD TFGGAIRTPT LSRLAQNGLI YNRFHVTAVC SPTRAALLTG RNHHRVGFGS
VCEFPGPYPG YSAVRPRSCA ALPRILRDNG YVTGAFGKWH LTPDNVQGAA GPFDNWPLGW
GFDHFWGFPS GAAGQYDPII SQDNSVIGIP EGSGEDGRPY YFPDDLTDKA IEWLHTVRAQ
NATKPWMLYY ATGATHAPHH VFKEWADKYR GEFDDGWDVY RQKTFERQKR LGIIPPDAEL
TERPDLFPAW DSMSEAQKRL FARQMEVFAG FSENADWNVG RLLDAIEDLG ESDNTLVFYI
WGDNGASMEG TNTGSFNEMT FLNGLDLDAE RQLELIEQYG GIAALGDEFT APHFASAWAH
ASNTPLQWGK QMASHLGGTR DPLVVAWPAR IRPDGRVRSQ FTHCIDIAPT VLAAIGLPEP
THVDGFEQEP MDGTSFVRTF DDAEAEDRHT VQYFENFGSR AIYKDGWWAC ARLDKAPWDL
SPETMRRFAP GTYDPDQDVW ELYYLPDDFS QAKNLAAEHP DKVAELTQLW WQEAERNRVL
PLLGGLAVMF GDLPPLPTTA RFSFKGDVQN IQRGMVPRIC GRSYAIEARL HIPDGGAQGV
IVANADFMGG FALWVDEQRH LHHTYSFLGV ETYRQVSSEP LPTGDVTVRM LFDSHQPVAA
SGGRVTLWAD DRLIGEGELP QTVPLAFTSY AGMDIGRDNG LVVDRGYEDK APYAFTGTVT
EVIFDLKPVH PEAARALHEH ASVQAVGQGA AG
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