ID Q7JHJ0_MACNE Unreviewed; 223 AA.
AC Q7JHJ0;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Cytotoxic T-lymphocyte protein 4 {ECO:0000256|ARBA:ARBA00016331};
DE AltName: Full=Cytotoxic T-lymphocyte-associated antigen 4 {ECO:0000256|ARBA:ARBA00032097};
GN Name=CTLA-4 {ECO:0000313|EMBL:AAK37537.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|EMBL:AAK37537.1};
RN [1] {ECO:0000313|EMBL:AAK37537.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11491535; DOI=10.1007/s002510100322;
RA Villinger F.J., Bostik P., Mayne A.E., King C.L., Genain C.P., Weiss W.R.,
RA Ansari A.A.;
RT "Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-
RT ligand and co-stimulatory molecules.";
RL Immunogenetics 53:315-328(2001).
RN [2] {ECO:0000313|Ensembl:ENSMNEP00000042127.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Inhibitory receptor acting as a major negative regulator of
CC T-cell responses. The affinity of CTLA4 for its natural B7 family
CC ligands, CD80 and CD86, is considerably stronger than the affinity of
CC their cognate stimulatory coreceptor CD28.
CC {ECO:0000256|ARBA:ARBA00002230}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AF344854; AAK37537.1; -; mRNA.
DR RefSeq; NP_001292846.1; NM_001305917.1.
DR RefSeq; XP_011716289.1; XM_011717987.1.
DR SMR; Q7JHJ0; -.
DR STRING; 9545.ENSMNEP00000042127; -.
DR Ensembl; ENSMNET00000066629.1; ENSMNEP00000042127.1; ENSMNEG00000043834.1.
DR Ensembl; ENSMNET00000066633.1; ENSMNEP00000042131.1; ENSMNEG00000043834.1.
DR GeneID; 105468054; -.
DR KEGG; mni:105468054; -.
DR CTD; 1493; -.
DR GeneTree; ENSGT00530000063873; -.
DR OMA; CASSYTT; -.
DR OrthoDB; 4108912at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000043834; Expressed in lymph node and 2 other cell types or tissues.
DR GO; GO:0045334; C:clathrin-coated endocytic vesicle; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0098636; C:protein complex involved in cell adhesion; IEA:Ensembl.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0045590; P:negative regulation of regulatory T cell differentiation; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0042129; P:regulation of T cell proliferation; IEA:InterPro.
DR CDD; cd05721; IgV_CTLA-4; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR008096; CTLA4.
DR InterPro; IPR040216; CTLA4/CD28.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR11494; CYTOTOXIC T-LYMPHOCYTE PROTEIN; 1.
DR PANTHER; PTHR11494:SF8; CYTOTOXIC T-LYMPHOCYTE PROTEIN 4; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01720; CTLANTIGEN4.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 162..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..152
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 53..131
FT /note="Immunoglobulin V-set"
FT /evidence="ECO:0000259|SMART:SM00406"
SQ SEQUENCE 223 AA; 24683 MW; BDE42248A00398FA CRC64;
MACLGFQRHK ARLNLATRTR PYTLLFSLLF IPVFSKAMHV AQPAVVLANS RGIASFVCEY
ASPGKATEVR VTVLRQADSQ VTEVCAATYM MGNELTFLDD SICTGTSSGN QVNLTIQGLR
AMDTGLYICK VELMYPPPYY MGIGNGTQIY VIDPEPCPDS DFLLWILAAV SSGLFFYSFL
LTAVSLSKML KKRSPLTTGV YVKMPPTEPE CEKQFQPYFI PIN
//
