ID Q7JLF4_CAEEL Unreviewed; 621 AA.
AC Q7JLF4;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 2.
DT 27-MAR-2024, entry version 160.
DE SubName: Full=WD_REPEATS_REGION domain-containing protein {ECO:0000313|EMBL:CAA99908.2};
GN ORFNames=CELE_R11D1.1 {ECO:0000313|EMBL:CAA99908.2}, R11D1.1
GN {ECO:0000313|EMBL:CAA99908.2, ECO:0000313|WormBase:R11D1.1a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA99908.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA99908.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA99908.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284605; CAA99908.2; -; Genomic_DNA.
DR RefSeq; NP_506172.2; NM_073771.4.
DR AlphaFoldDB; Q7JLF4; -.
DR EPD; Q7JLF4; -.
DR EnsemblMetazoa; R11D1.1a.1; R11D1.1a.1; WBGene00011242.
DR UCSC; R11D1.1b; c. elegans.
DR AGR; WB:WBGene00011242; -.
DR WormBase; R11D1.1a; CE38535; WBGene00011242; -.
DR GeneTree; ENSGT00950000182900; -.
DR OrthoDB; 2968013at2759; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00011242; Expressed in adult organism and 4 other cell types or tissues.
DR ExpressionAtlas; Q7JLF4; baseline and differential.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR045151; DCAF8.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15574:SF43; DDB1- AND CUL4-ASSOCIATED FACTOR 5; 1.
DR PANTHER; PTHR15574; WD REPEAT DOMAIN-CONTAINING FAMILY; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:Q7JLF4,
KW ECO:0007829|PeptideAtlas:Q7JLF4};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 362..394
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 460..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..494
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..573
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..621
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 621 AA; 71721 MW; 686A2DA5D5114407 CRC64;
MLVEEEPPPE NEENMDIEIS KSTNNQFKIE SFLCQREIGS VKSVVKTFRP DFQHRPFCQK
DVREHTGCIN ALQFSHNDRF LASGDDMHGR VWNVDELMVR KTPKPIGVME HPHRSNIFSL
EFDLENRFLY SGERWGTVIK HDIETKQSIY VANENNNRGD VYHMDQHPTD NTLIVVTRAK
LVSFIDNRDR QNPISLVLPA NSGKNFYTAE FHPETPALIL VNSETGGPNV FDRRMQARPV
YQRSMFKGLP QENTEWMGSL WSPSGNQFMS IRRGKCPLYF DFISQRCFVL KSDHNPNGYC
NIKTIKSMTF IDDYTVATGS DHWGIHIWKL PRANDSYGFT QIGHDEEEMP SEIFIEKELT
VLRGHRSVPN QVRFSQHNNL LVSSGVENSF KLWSDHRLPW SYDLPFERRP HGTYDLSAEE
ECLREMEERR VVEDALDLNG EMDGRACWRD IFGGDARTAE DRDTLEMFDP RGHGDDEEDV
EESSSEDSDD MMDNEADDNH YFRRRRGPLQ LFVLLQRAGE EHLARMLEEH DGVENDLLEE
LFNMRRRFRE ESSDEDDSGD DGENGDENDN ENDNIESSSS NSDSSDASEV GDLMDFDGDD
EEEDEGDDEA AIEEQDSDSE A
//
