ID Q7K860_DROME Unreviewed; 153 AA.
AC Q7K860;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 157.
DE SubName: Full=FI07231p {ECO:0000313|EMBL:ACH92385.1};
DE SubName: Full=GEO12704p1 {ECO:0000313|EMBL:ANY27639.1};
DE SubName: Full=Troponin C {ECO:0000313|EMBL:AAQ21105.1, ECO:0000313|EMBL:CAD55594.1};
DE SubName: Full=Troponin C isoform 4, isoform A {ECO:0000313|EMBL:AAF57327.2};
DE SubName: Full=Troponin C isoform 4, isoform B {ECO:0000313|EMBL:ACZ94335.1};
GN Name=TpnC4 {ECO:0000313|EMBL:AAF57327.2,
GN ECO:0000313|FlyBase:FBgn0033027};
GN Synonyms=BcDNA:RH03361 {ECO:0000313|EMBL:AAF57327.2}, Dmel\CG12408
GN {ECO:0000313|EMBL:AAF57327.2}, DmTnC4 {ECO:0000313|EMBL:AAF57327.2},
GN DmTpnC41F {ECO:0000313|EMBL:AAF57327.2}, DmTpnCIIIb
GN {ECO:0000313|EMBL:AAF57327.2}, TnC {ECO:0000313|EMBL:AAF57327.2}, TnC4
GN {ECO:0000313|EMBL:AAF57327.2}, Tnc4 {ECO:0000313|EMBL:AAF57327.2},
GN tnC4 {ECO:0000313|EMBL:CAD55594.1}, TNC41F6
GN {ECO:0000313|EMBL:AAF57327.2}, TpnC IIIb
GN {ECO:0000313|EMBL:AAF57327.2}, tpnc4 {ECO:0000313|EMBL:AAF57327.2},
GN TpnC4-RA {ECO:0000313|EMBL:ACH92385.1}, TpnC41F
GN {ECO:0000313|EMBL:AAF57327.2}, TpnCIIIb {ECO:0000313|EMBL:AAF57327.2};
GN ORFNames=CG12408 {ECO:0000313|EMBL:AAF57327.2,
GN ECO:0000313|FlyBase:FBgn0033027}, Dmel_CG12408
GN {ECO:0000313|EMBL:AAF57327.2};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:CAD55594.1};
RN [1] {ECO:0000313|EMBL:AAF57327.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AAF57327.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AAF57327.2, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AAF57327.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AAF57327.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:CAD55594.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Indirect flight muscle {ECO:0000313|EMBL:CAD55594.1};
RX PubMed=12558500; DOI=10.1042/BJ20021814;
RA Qiu F., Lakey A., Agianian B., Hutchings A., Butcher G.W., Labeit S.,
RA Leonard K., Bullard B.;
RT "Troponin C in different insect muscle types: identification of two
RT isoforms in Lethocerus, Drosophila and Anopheles that are specific to
RT asynchronous flight muscle in the adult insect.";
RL Biochem. J. 371:811-821(2003).
RN [7] {ECO:0000313|EMBL:AAQ21105.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Oregon R {ECO:0000313|EMBL:AAQ21105.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:AAQ21105.1};
RX PubMed=15161098; DOI=10.1016/j.modgep.2003.09.008;
RA Herranz R., Diaz-Castillo C., Nguyen T.P., Lovato T.L., Cripps R.M.,
RA Marco R.;
RT "Expression patterns of the whole troponin C gene repertoire during
RT Drosophila development.";
RL Gene Expr. Patterns 4:183-190(2004).
RN [8] {ECO:0000313|EMBL:AAF57327.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [9] {ECO:0000313|EMBL:AAF57327.2}
RP NUCLEOTIDE SEQUENCE.
RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA Svirskas R., Rubin G.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:AAF57327.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [11] {ECO:0000313|EMBL:AAF57327.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
RN [12] {ECO:0000313|EMBL:ACH92385.1}
RP NUCLEOTIDE SEQUENCE.
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:AAF57327.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109357; DOI=.1534/g3.115.018929;
RG FlyBase Consortium;
RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E.,
RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M.,
RA Gelbart W.M., null;
RT "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT Throughput Data.";
RL G3 (Bethesda) 5:1721-1736(2015).
RN [14] {ECO:0000313|EMBL:AAF57327.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109356; DOI=.1534/g3.115.018937;
RG FlyBase Consortium;
RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E.,
RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.,
RA null;
RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.";
RL G3 (Bethesda) 5:1737-1749(2015).
RN [15] {ECO:0000313|EMBL:AAF57327.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25589440;
RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E.,
RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M.,
RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M.,
RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M.,
RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M.,
RA Karpen G.H., Celniker S.E.;
RT "The Release 6 reference sequence of the Drosophila melanogaster genome.";
RL Genome Res. 25:445-458(2015).
RN [16] {ECO:0000313|EMBL:ANY27639.1}
RP NUCLEOTIDE SEQUENCE.
RA Wan K., Booth B., Spirohn K., Hao T., Hu Y., Calderwood M., Hill D.,
RA Mohr S., Vidal M., Celniker S., Perrimon N.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [17] {ECO:0000313|EMBL:AAF57327.2}
RP NUCLEOTIDE SEQUENCE.
RG FlyBase;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN [18] {ECO:0000313|EMBL:AAF57327.2}
RP NUCLEOTIDE SEQUENCE.
RG Berkeley Drosophila Genome Project;
RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C.,
RA Rubin G.;
RT "Drosophila melanogaster release 4 sequence.";
RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AE013599; AAF57327.2; -; Genomic_DNA.
DR EMBL; AY283602; AAQ21105.1; -; mRNA.
DR EMBL; BT044320; ACH92385.1; -; mRNA.
DR EMBL; AE013599; ACZ94335.1; -; Genomic_DNA.
DR EMBL; KX531829; ANY27639.1; -; mRNA.
DR EMBL; AJ512938; CAD55594.1; -; mRNA.
DR RefSeq; NP_001163055.1; NM_001169584.2.
DR RefSeq; NP_610173.2; NM_136329.3.
DR AlphaFoldDB; Q7K860; -.
DR SMR; Q7K860; -.
DR IntAct; Q7K860; 4.
DR STRING; 7227.FBpp0085411; -.
DR PaxDb; 7227-FBpp0085411; -.
DR DNASU; 35498; -.
DR EnsemblMetazoa; FBtr0086075; FBpp0085411; FBgn0033027.
DR EnsemblMetazoa; FBtr0302019; FBpp0291229; FBgn0033027.
DR GeneID; 35498; -.
DR KEGG; dme:Dmel_CG12408; -.
DR UCSC; CG12408-RA; d. melanogaster.
DR AGR; FB:FBgn0033027; -.
DR CTD; 35498; -.
DR FlyBase; FBgn0033027; TpnC4.
DR VEuPathDB; VectorBase:FBgn0033027; -.
DR eggNOG; KOG0027; Eukaryota.
DR GeneTree; ENSGT00940000172595; -.
DR HOGENOM; CLU_061288_2_4_1; -.
DR InParanoid; Q7K860; -.
DR OMA; PWNTNEL; -.
DR OrthoDB; 382054at2759; -.
DR BioGRID-ORCS; 35498; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35498; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033027; Expressed in second segment of antenna (Drosophila) and 14 other cell types or tissues.
DR ExpressionAtlas; Q7K860; baseline and differential.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030234; F:enzyme regulator activity; IBA:GO_Central.
DR GO; GO:0060361; P:flight; IMP:FlyBase.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR23048:SF0; FI08416P-RELATED; 1.
DR PANTHER; PTHR23048; MYOSIN LIGHT CHAIN 1, 3; 1.
DR Pfam; PF13499; EF-hand_7; 2.
DR SMART; SM00054; EFh; 4.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q7K860};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 9..44
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 86..121
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 122..153
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 153 AA; 17000 MW; 1622131633AF8A7F CRC64;
MADGEYDKEQ LRILRNAFKA FDHDGAGSIE HADVSSILEI LGQKLEPPAV KALIKEVDKG
TTGKLDFSQF CKLAARFIEV EEDVGALQNE LKEAFRVYDK EGKGYLTVAT LRGILHELDD
KLSNQDLDMI IEEIDADGSG TVDFDEFMQV MTG
//
