ID THIO_PLAF7 Reviewed; 104 AA.
AC Q7KQL8;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-APR-2013, entry version 67.
DE RecName: Full=Thioredoxin;
DE Short=Trx;
GN ORFNames=PF14_0545;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T.,
RA James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A.,
RA Kyes S., Chan M.-S., Nene V., Shallom S.J., Suh B., Peterson J.,
RA Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W.,
RA Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S.,
RA Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M.,
RA Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C.,
RA Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium
RT falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS), AND DISULFIDE BOND.
RA Robien M.A., Hol W.G.J.;
RT "Structural genomics of pathogenic protozoa initial structural
RT analysis of Plasmodium falciparum thioredoxin.";
RL Submitted (APR-2004) to the PDB data bank.
CC -!- FUNCTION: Participates in various redox reactions through the
CC reversible oxidation of its active center dithiol to a disulfide
CC and catalyzes dithiol-disulfide exchange reactions (By
CC similarity).
CC -!- SIMILARITY: Belongs to the thioredoxin family.
CC -!- SIMILARITY: Contains 1 thioredoxin domain.
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DR EMBL; AE014187; AAN37158.1; -; Genomic_DNA.
DR RefSeq; XP_001348719.1; XM_001348683.1.
DR PDB; 1SYR; X-ray; 2.95 A; A/B/C/D/E/F/G/H/I/J/K/L=1-104.
DR PDBsum; 1SYR; -.
DR ProteinModelPortal; Q7KQL8; -.
DR SMR; Q7KQL8; 1-103.
DR IntAct; Q7KQL8; 1.
DR MINT; MINT-1625012; -.
DR STRING; 5833.PF14_0545-1; -.
DR EnsemblProtists; PF14_0545:mRNA; PF14_0545:pep; PF14_0545.
DR GeneID; 812127; -.
DR KEGG; pfa:PF14_0545; -.
DR EuPathDB; PlasmoDB:PF3D7_1457200; -.
DR HOGENOM; HOG000292977; -.
DR KO; K03671; -.
DR OMA; LLNWISN; -.
DR ProtClustDB; PTZ00051; -.
DR EvolutionaryTrace; Q7KQL8; -.
DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR GO; GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
DR GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR GO; GO:0006662; P:glycerol ether metabolic process; IEA:InterPro.
DR Gene3D; 3.40.30.10; -; 1.
DR InterPro; IPR005746; Thioredoxin.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR10438; PTHR10438; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR PIRSF; PIRSF000077; Thioredoxin; 1.
DR PRINTS; PR00421; THIOREDOXIN.
DR SUPFAM; SSF52833; Thiordxn-like_fd; 1.
DR TIGRFAMs; TIGR01068; thioredoxin; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Disulfide bond; Electron transport;
KW Redox-active center; Reference proteome; Transport.
FT CHAIN 1 104 Thioredoxin.
FT /FTId=PRO_0000233976.
FT DOMAIN 2 104 Thioredoxin.
FT ACT_SITE 30 30 Nucleophile (By similarity).
FT ACT_SITE 33 33 Nucleophile (By similarity).
FT SITE 24 24 Deprotonates C-terminal active site Cys
FT (By similarity).
FT SITE 31 31 Contributes to redox potential value (By
FT similarity).
FT SITE 32 32 Contributes to redox potential value (By
FT similarity).
FT DISULFID 30 33 Redox-active.
FT STRAND 3 5
FT HELIX 8 17
FT STRAND 19 26
FT HELIX 31 46
FT STRAND 50 56
FT TURN 57 60
FT HELIX 61 66
FT STRAND 71 79
FT STRAND 82 89
FT HELIX 92 100
SQ SEQUENCE 104 AA; 11716 MW; 0129998AEB88770C CRC64;
MVKIVTSQAE FDSIISQNEL VIVDFFAEWC GPCKRIAPFY EECSKTYTKM VFIKVDVDEV
SEVTEKENIT SMPTFKVYKN GSSVDTLLGA NDSALKQLIE KYAA
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