ID DCA13_DICDI Reviewed; 445 AA.
AC Q7KWL3; Q550M9;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=DDB1- and CUL4-associated factor 13;
DE AltName: Full=WD repeat and SOF domain-containing protein 1;
GN Name=wdsof1; ORFNames=DDB_G0276815;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Possible role in ribosomal RNA processing. May function as a
CC substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
CC (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat DCAF13/WDSOF1 family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000019; EAL68909.1; -; Genomic_DNA.
DR RefSeq; XP_642903.1; XM_637811.1.
DR AlphaFoldDB; Q7KWL3; -.
DR SMR; Q7KWL3; -.
DR STRING; 44689.Q7KWL3; -.
DR PaxDb; 44689-DDB0168265; -.
DR EnsemblProtists; EAL68909; EAL68909; DDB_G0276815.
DR GeneID; 8620769; -.
DR KEGG; ddi:DDB_G0276815; -.
DR dictyBase; DDB_G0276815; -.
DR eggNOG; KOG0268; Eukaryota.
DR HOGENOM; CLU_033999_0_0_1; -.
DR InParanoid; Q7KWL3; -.
DR OMA; EDHNAYI; -.
DR PhylomeDB; Q7KWL3; -.
DR Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-DDI-8951664; Neddylation.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q7KWL3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR007287; Sof1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22851:SF0; DDB1- AND CUL4-ASSOCIATED FACTOR 13; 1.
DR PANTHER; PTHR22851; U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN; 1.
DR Pfam; PF04158; Sof1; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; Ubl conjugation pathway; WD repeat.
FT CHAIN 1..445
FT /note="DDB1- and CUL4-associated factor 13"
FT /id="PRO_0000342367"
FT REPEAT 64..104
FT /note="WD 1"
FT REPEAT 107..146
FT /note="WD 2"
FT REPEAT 154..192
FT /note="WD 3"
FT REPEAT 196..235
FT /note="WD 4"
FT REPEAT 237..277
FT /note="WD 5"
FT REPEAT 281..320
FT /note="WD 6"
FT REPEAT 324..363
FT /note="WD 7"
FT REGION 417..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 51067 MW; D9BDC448BE124B10 CRC64;
MKIKVISRSE EEETKEKASD VRKLHRNLDP NLHPFERPRE YVRALNATKL DRVFAKPFIG
SLSGHTDGIF TMTRHPTLLN NVASGSCDGV IKLWNLTSLT ERTTVQAHNG FVRGLVFTPD
GKHMVSCGED KTIKMWKLDL PEYTFNQEVI SIYNGKNAFT SIDHQLNSTT FATSGPTSVE
IWKHQRSTPI QTLQWGHSTI TKVKFNPIET HLLASCTTDR DIILYDIREN SPAQKLTTSM
RSNSIAWCPT ESFTLAIANE DENVYQYDIR NLSKAMTVHR DHVGSVLDID YSPTGREIVS
GSYDKTIRIF PVDSYKSREV YYTNRMQRIF SVLFTADSRF ILSGSDDMNI RVWKANSSAP
LGILSNREKE KLEYQDKIKE KFKEIPELKT IATHRRVPQL VYKRRFIKNE IHKAKQRRVK
NISNNSGKSP KVEKVLSKHT IKVDN
//
