ID Q7MXD3_PORGI Unreviewed; 308 AA.
AC Q7MXD3;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE SubName: Full=Redox-sensitive transcriptional activator OxyR {ECO:0000313|EMBL:AAQ65490.1};
GN Name=oxyR {ECO:0000313|EMBL:AAQ65490.1};
GN OrderedLocusNames=PG_0270 {ECO:0000313|EMBL:AAQ65490.1};
OS Porphyromonas gingivalis (strain ATCC BAA-308 / W83).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC Porphyromonas.
OX NCBI_TaxID=242619 {ECO:0000313|EMBL:AAQ65490.1, ECO:0000313|Proteomes:UP000000588};
RN [1] {ECO:0000313|EMBL:AAQ65490.1, ECO:0000313|Proteomes:UP000000588}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-308 / W83 {ECO:0000313|Proteomes:UP000000588};
RX PubMed=12949112; DOI=10.1128/JB.185.18.5591-5601.2003;
RA Nelson K., Fleishmann R., DeBoy R., Paulsen I., Fouts D., Eisen J.,
RA Daugherty S., Dodson R., Durkin A., Gwinn M., Haft D., Kolonay J.,
RA Nelson W., White O., Mason T., Tallon L., Gray J., Granger D., Tettelin H.,
RA Dong H., Galvin J., Duncan M., Dewhirst F., Fraser C.;
RT "Complete genome sequence of the oral pathogenic bacterium Porphyromonas
RT gingivalis strain W83.";
RL J. Bacteriol. 185:5591-5601(2003).
RN [2] {ECO:0007829|PDB:3HO7}
RP X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 81-308, AND DISULFIDE BONDS.
RX PubMed=24100327; DOI=10.1107/S0907444913019471;
RA Svintradze D.V., Peterson D.L., Collazo-Santiago E.A., Lewis J.P.,
RA Wright H.T.;
RT "Structures of the Porphyromonas gingivalis OxyR regulatory domain explain
RT differences in expression of the OxyR regulon in Escherichia coli and P.
RT gingivalis.";
RL Acta Crystallogr. D 69:2091-2103(2013).
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000256|ARBA:ARBA00009437}.
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DR EMBL; AE015924; AAQ65490.1; -; Genomic_DNA.
DR RefSeq; WP_005874484.1; NC_002950.2.
DR PDB; 3HO7; X-ray; 1.58 A; A/B=81-308.
DR PDBsum; 3HO7; -.
DR AlphaFoldDB; Q7MXD3; -.
DR SMR; Q7MXD3; -.
DR STRING; 242619.PG_0270; -.
DR EnsemblBacteria; AAQ65490; AAQ65490; PG_0270.
DR GeneID; 29255608; -.
DR KEGG; pgi:PG_0270; -.
DR eggNOG; COG0583; Bacteria.
DR HOGENOM; CLU_039613_6_4_10; -.
DR EvolutionaryTrace; Q7MXD3; -.
DR Proteomes; UP000000588; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd08411; PBP2_OxyR; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30419; HTH-TYPE TRANSCRIPTIONAL REGULATOR YBHD; 1.
DR PANTHER; PTHR30419:SF31; LYSR FAMILY TRANSCRIPTIONAL REGULATOR-RELATED; 1.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3HO7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000588}.
FT DOMAIN 1..58
FT /note="HTH lysR-type"
FT /evidence="ECO:0000259|PROSITE:PS50931"
FT DISULFID 199..208
FT /evidence="ECO:0007829|PDB:3HO7"
SQ SEQUENCE 308 AA; 35146 MW; A77295EC5AFEF380 CRC64;
MNIQQLEYIA ALDKFRHFAK AADYCNVSQP TLSTMILKLE EELGAKLFDR SRQPIEPTSI
GALVVSQAKQ ILYDLNSITR IIEEEQQSLT GRLNIAVLPT IAPYLLPRVF PIWKKELAGL
EIHVSEMQTS RCLASLLSGE IDMAIIASKA ETEGLEDDLL YYEEFLGYVS RCEPLFEQDV
IRTTEVNPHR LWLLDEGHCF RDQLVRFCQM KGLHERQTAY SGGSMEAFMR LVESGQGITF
IPQLTVEQLS PSQKELVRPF GMPRPVREVR LAVRQDYSRR KLREQLIGLL RSAVPSDMHK
LQTGQHLA
//
