ID   Q7N4W1_PHOLL            Unreviewed;       294 AA.
AC   Q7N4W1;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2003, sequence version 1.
DT   27-MAR-2024, entry version 124.
DE   SubName: Full=Hca operon transcriptional activator {ECO:0000313|EMBL:CAE14496.1};
GN   Name=hcaR {ECO:0000313|EMBL:CAE14496.1};
GN   OrderedLocusNames=plu2203 {ECO:0000313|EMBL:CAE14496.1};
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01) (Photorhabdus luminescens subsp. laumondii).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265 {ECO:0000313|EMBL:CAE14496.1, ECO:0000313|Proteomes:UP000002514};
RN   [1] {ECO:0000313|Proteomes:UP000002514}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01
RC   {ECO:0000313|Proteomes:UP000002514};
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000256|ARBA:ARBA00009437}.
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DR   EMBL; BX571866; CAE14496.1; -; Genomic_DNA.
DR   RefSeq; WP_011146455.1; NC_005126.1.
DR   AlphaFoldDB; Q7N4W1; -.
DR   STRING; 243265.plu2203; -.
DR   GeneID; 24166436; -.
DR   KEGG; plu:plu2203; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_4_6; -.
DR   OrthoDB; 5289754at2; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08450; PBP2_HcaR; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30346:SF0; HCA OPERON TRANSCRIPTIONAL ACTIVATOR HCAR; 1.
DR   PANTHER; PTHR30346; TRANSCRIPTIONAL DUAL REGULATOR HCAR-RELATED; 1.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002514};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        226..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50931"
SQ   SEQUENCE   294 AA;  33271 MW;  A8F33EA9D6C468F1 CRC64;
     MELRHLRYFI AVAEELNFTK AAKKLHTAQP SLSQQIKDLE DYIGSTLLER NKRRVSLTKA
     GEVFLQQARL ILENAEKAKK MARRAAQEQI VLTIGFVPSA EVKVLPEVIP IFRLAHPGAK
     VELISLFNPG QEEKLLQGDI DVAFMRPPIK SDSIDFKVIL NEPLVVLMPA NHRLRYCEKI
     SVNDLQGENF ITPDPTQSGV LQQIIENYFT EHNVVPNIIQ TANNMLLILN MVSLNLGCAI
     VPFYITSIMT DAVICRPLSG YSPTIELIMA WRKDNTSELL LHLIDVVENK YLQE
//