ID Q7NDX1_GLOVI Unreviewed; 339 AA.
AC Q7NDX1;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:BAC92052.1};
GN OrderedLocusNames=gll4111 {ECO:0000313|EMBL:BAC92052.1};
OS Gloeobacter violaceus (strain ATCC 29082 / PCC 7421).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Gloeobacterales; Gloeobacteraceae;
OC Gloeobacter.
OX NCBI_TaxID=251221 {ECO:0000313|EMBL:BAC92052.1, ECO:0000313|Proteomes:UP000000557};
RN [1] {ECO:0000313|EMBL:BAC92052.1, ECO:0000313|Proteomes:UP000000557}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29082 / PCC 7421 {ECO:0000313|Proteomes:UP000000557};
RX PubMed=14621292; DOI=10.1093/dnares/10.4.137;
RA Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T.,
RA Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M.,
RA Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M.,
RA Tabata S.;
RT "Complete genome structure of Gloeobacter violaceus PCC 7421, a
RT cyanobacterium that lacks thylakoids.";
RL DNA Res. 10:137-145(2003).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR EMBL; BA000045; BAC92052.1; -; Genomic_DNA.
DR RefSeq; NP_927057.1; NC_005125.1.
DR AlphaFoldDB; Q7NDX1; -.
DR STRING; 251221.gene:10761629; -.
DR EnsemblBacteria; BAC92052; BAC92052; BAC92052.
DR KEGG; gvi:gll4111; -.
DR PATRIC; fig|251221.4.peg.4143; -.
DR eggNOG; COG1064; Bacteria.
DR HOGENOM; CLU_026673_20_1_3; -.
DR InParanoid; Q7NDX1; -.
DR OrthoDB; 9770526at2; -.
DR PhylomeDB; Q7NDX1; -.
DR Proteomes; UP000000557; Chromosome.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08296; CAD_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42940; ALCOHOL DEHYDROGENASE 1-RELATED; 1.
DR PANTHER; PTHR42940:SF7; ALCOHOL DEHYDROGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000557};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 13..335
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 339 AA; 35521 MW; FFCBA2423A1F3159 CRC64;
MTKMRAMIVP EAGAKFQMIE RDLPVPGPRE VRLSVSACGV CHSDSVTVEG TMRGIAYPRV
PGHEVIGTIE ALGPEVLGWE VSMRVGVGWF GGSCGYCAHC RRGSAFACET VSAVTGVTRD
GGYATHMLAD VSALAHVPTD LDVVESAPLL CAGITTFNAL RNCGAGPGEL VAIHGIGGLG
HLGIQFAARQ GFRTVAVNRG RDKEELARSL GAHEYIDSEE GDPAAALLAM GGAKAILATV
TSEKAMQALV GGLGPNGTMM LIGAVPTLTV NPTELLLKRA AVKGWYSGTA ADSEDTLLFS
HRNGITSMNE IYPFENAQAA YDRMMSGKAR FRVVLSMGV
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