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Database: UniProt
Entry: Q7PQV4_ANOGA
LinkDB: Q7PQV4_ANOGA
Original site: Q7PQV4_ANOGA 
ID   Q7PQV4_ANOGA            Unreviewed;      2632 AA.
AC   Q7PQV4;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 5.
DT   25-OCT-2017, entry version 99.
DE   SubName: Full=AGAP002505-PA {ECO:0000313|EMBL:EAA08229.6};
DE   SubName: Full=Voltage-dependent calcium channel alpha 1, invertebrate {ECO:0000313|VectorBase:AGAP002505-PA};
GN   Name=1273457 {ECO:0000313|VectorBase:AGAP002505-PA};
GN   ORFNames=AgaP_AGAP002505 {ECO:0000313|EMBL:EAA08229.6};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA08229.6, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|VectorBase:AGAP002505-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP002505-PA};
RX   PubMed=9087549; DOI=10.1111/j.1365-2583.1993.tb00131.x;
RA   Beard C.B., Hamm D.M., Collins F.H.;
RT   "The mitochondrial genome of the mosquito Anopheles gambiae: DNA
RT   sequence, genome organization, and comparisons with mitochondrial
RT   sequences of other insects.";
RL   Insect Mol. Biol. 2:103-124(1993).
RN   [2] {ECO:0000313|EMBL:EAA08229.6, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA08229.6,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M., Wides R.,
RA   Salzberg S.L., Loftus B., Yandell M., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A., Liang Y., Lin J.J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z., Unger M.F., Walenz B., Wang A., Wang J.,
RA   Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [3] {ECO:0000313|EMBL:EAA08229.6}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA08229.6};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:EAA08229.6}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA08229.6};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [5] {ECO:0000313|EMBL:EAA08229.6}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA08229.6};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5-R5(2007).
RN   [6] {ECO:0000313|EMBL:EAA08229.6}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA08229.6};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|VectorBase:AGAP002505-PA}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP002505-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   EMBL; AAAB01008859; EAA08229.6; -; Genomic_DNA.
DR   RefSeq; XP_312434.5; XM_312434.5.
DR   STRING; 7165.AGAP002505-PA; -.
DR   PaxDb; Q7PQV4; -.
DR   EnsemblMetazoa; AGAP002505-RA; AGAP002505-PA; AGAP002505.
DR   GeneID; 1273457; -.
DR   KEGG; aga:AgaP_AGAP002505; -.
DR   VectorBase; AGAP002505-RA; AGAP002505-PA; AGAP002505.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   InParanoid; Q7PQV4; -.
DR   KO; K04854; -.
DR   OrthoDB; EOG091G02L1; -.
DR   PhylomeDB; Q7PQV4; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    198    217       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    285    305       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    408    426       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    446    471       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1051   1073       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1129   1155       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1672   1693       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1769   1791       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1872   1895       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1952   1973       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1985   2003       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2085   2105       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2170   2196       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      159    478       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      922   1161       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1633   1905       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1951   2205       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     2196   2223       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2632 AA;  295260 MW;  8615CDDAD3BD3DBF CRC64;
     MRNAAKDTVA SQQPAAFTDK VNYGGGVIES INLKNDRNGA PTAQQHRNSL QQHQQQQQLQ
     KRPSVVKGGP GGGRGTARHV STSSEATDTS GSSCSDGDTT SSSYDEPNLP YPGFTEYSLK
     YLTQDSKPRI WCLQLITNPY PFQIASKSPI LPPPLPHSNR ISMLVILLNC VTLGMYQPCV
     DDACVTNRCK ILQIFDDIIF AFFSLEMTIK IVAMGAWGKG TYLADSWNRL DFFIVLAGAL
     EYCLQVENLN LTAIRTIRVL RPLRAINRIP SMRILVMLLL DTLPMLGNVL LLCFFVFFIF
     GIVGVQLWEG ILRQRCVIKL PDNVSPPSYL VSFYYEFSKE QDYICSKPED SGMHLCQNLP
     PYRIGPLLCN DSALPYSENE PTATACVNWN QYYTNCTQLG NNPFQGTISF DNIGLAWVAI
     FLVISLEGWT DIMYYVQDAH SFWDWIYFVL LIVIGSFFMI NLCLVVIATQ FSETKKREME
     RMRQERARFT SSSTLASSTN NSEPTTCYAE IVKYIGHLYR RFKRRLIKKL RLYNLHRYCT
     IESSFFFSLS LSLSLSFSHS FSIHLHGHRR YHMQKRKEGL IPCTPETITL SPNKIKAHHP
     KCPRMGALLQ QQHASITNLQ QQKNKHDLQS SLSINRTGVT LNHPEPGTIV PSADNQVSSP
     EVSEIDRQKV LLLKINNEDQ SNGQVRGMGW LWGMDHHCMP SLLSPPSAGR RRSSVMFNEY
     VVLHTPPTIT EPPQDKNVYC LEKMTQAGDG SIWQVLYIHH WIVANDVWKL DLLSTVFNEY
     SDLCLSDAMT CQELLAFSVA FSAALPTGQT TLESFYTSLK RAKGAEPARQ TNATLPLPEI
     ERLSSKSSNE PSRTSFDPVS AGINNINMEE FACCYEYYQN QGLAEEKRPQ RSKCARALLA
     VWRCFRRTCH LTRVLVKKLV DHKYFQQGIL LAILINTLSM GIEYHDQPAE LTAIVETSNI
     VFSAIFAVEM ILKVIAEGPF RYVANGFNVF DGVIVILSVV ELGQSYLGEG QGSSGLSVLR
     TFRLLRILKL VRFMPNLRRQ LFVMLRTMDN VAIFFSLLIL FIFIFSILGM NLFGCKFCEK
     NETAGEVECD RKNFDSLLWA LVTVFQILTQ EDWNVVLFNG MEKTSHWAAL YFVTLMTFGN
     YVLFNLLVAI LVEGFSSERN ERREREQREL VKAKLNAEAL AQEQSMEVYD DQRSFSESST
     TDSYNGSRGK WYSVEELTKV RNLDIKCNIQ KQRLLQPNYE DPKNVAQKNK REKDVSKPEP
     TATKKLRGKK AESLKLYNIQ VQDPPIITTT AATPQDSPSG TMESGTSFKD WDQADFEKYE
     RENSSLLKPP SILGSLKTLD DRSFFEGTPV LNEMRKKHDK NHTTSSDSRL SVVDKQQKKQ
     QEKSLTESAS APKAVGKDET ANGGLHRQAS TEEGVLNNGK ILSQPKGKNG FGATDRRTLD
     PLLEKSNRIQ NDTQGSRTPN RRRSSVRRSS SVKVDSGASS IASNLSLTSH PRCYYNNGST
     KYYFDRKNSL RLCDIRTPNN RRRMSSFEQA YHKQSPMSSI RNLEIKQLQD EMDKGKLDKS
     SNAFKIAGNS TDLTGKATRN DGTPKKKGKG RLKQFFRMVT PYHFVEDHET YTLYLFPEHN
     RFRQICSWFV NQKWFDNVIL LFIALNCITL AMERPNIPPN CTERYFLATA NYVFTGVFAV
     EMFIKVVSAG LFYGPDAYFT SGWNIMDGSL VTISIVDLLM SLISESSPRI FGILRVFRLL
     RSLRPLRVIN RAPGLKLVVQ TLLSSLRPIG NIVLICCTFF IIFGILGVQL FKGTFYYCEG
     ENIKGVKNKQ DCLAIEGNVW INRKYNFDDL GKALMSLFVL SSRDGWVNIM YTGLDAVGVD
     QQPIVNYNEW RLLYFIAFIL LVGFFVLNMF VGVVVENFHR CREEQEKEEK IRRAAKRALQ
     MEKKRKRMHE PPYYTNYSPM RLFVHNVVTS KYFDLAIAAV IGLNVVTMAM EYYMMPLALE
     YALKIFNYFF TAVFILEAAM KLLALGVKIY MKDRWNQLDV AIVILSIVGI VLEELETNII
     PINPTIIRVM RVLRIARVLK LLKMAKGIRA LLDTVMQALP QVGNLGLLFF LLFFIFAALG
     VELFGRLECS DEVPCQGLGE HAHFANFGMA FLTLFRVATG DNWNGIMKDT LRDDCDDAAD
     CVKNCCVSTI IAPIFFVIFV LMAQFVLVNV VVAVLMKHLE ESHKQMEDDL DIETELEREF
     EREQEFEEEQ ALCMQLNDDN NQVQKRPLTK VSSLPSNFTY STPILEKKSN IQRRQTIQYF
     NQNLGLSVFN SYTNNNSYDE TAENNINAEG EELDPGGGVP GARDECEEKK MKKIGEGVGG
     LVAADGGKGV GSDGLNSAKE YNVNSKNVNK KILINKTNLF SKSCDGRPSG GDGKRGKGGF
     KEECLNISIP AVPLVIGGAG KPETGRPDDP HHRGASAPAG LADGSEGDVP VESQCSTITS
     SSRSRHQAGS KLESRQLSLD YEPTRTPRPN PDGDGVPPAT DGCVPVAPAG PGPASSAVGN
     GGSSNTTTSG STVSNKSFLS VPKLQPKSRS GSTKQLFKQS ALDEDGETND ESSLLLPVAT
     VADSGGPGSN HCHGGGGTLL AIPGEGGGFG ADTVKNSESC EIIRIISERR KI
//
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