ID Q7PSM8_ANOGA Unreviewed; 595 AA.
AC Q7PSM8;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 4.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=AGAP004065-PA {ECO:0000313|EMBL:EAA05338.5};
GN Name=1270861 {ECO:0000313|EnsemblMetazoa:AGAP004065-PA};
GN ORFNames=AgaP_AGAP004065 {ECO:0000313|EMBL:EAA05338.5};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA05338.5};
RN [1] {ECO:0000313|EMBL:EAA05338.5, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05338.5,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA05338.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05338.5};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA05338.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05338.5};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA05338.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05338.5};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA05338.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05338.5};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP004065-PA}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP004065-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the strictosidine synthase family.
CC {ECO:0000256|ARBA:ARBA00009191}.
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DR EMBL; AAAB01008817; EAA05338.5; -; Genomic_DNA.
DR RefSeq; XP_309617.4; XM_309617.5.
DR AlphaFoldDB; Q7PSM8; -.
DR STRING; 7165.Q7PSM8; -.
DR PaxDb; 7165-AGAP004065-PA; -.
DR EnsemblMetazoa; AGAP004065-RA; AGAP004065-PA; AGAP004065.
DR GeneID; 1270861; -.
DR KEGG; aga:AgaP_AGAP004065; -.
DR VEuPathDB; VectorBase:AGAP004065; -.
DR eggNOG; KOG1520; Eukaryota.
DR HOGENOM; CLU_023267_1_0_1; -.
DR InParanoid; Q7PSM8; -.
DR OMA; IYEESRC; -.
DR OrthoDB; 1066791at2759; -.
DR Proteomes; UP000007062; Chromosome 2R.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IBA:GO_Central.
DR GO; GO:0016844; F:strictosidine synthase activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR018119; Strictosidine_synth_cons-reg.
DR PANTHER; PTHR10426:SF106; ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED; 1.
DR PANTHER; PTHR10426; STRICTOSIDINE SYNTHASE-RELATED; 1.
DR Pfam; PF20067; SSL_N; 1.
DR Pfam; PF03088; Str_synth; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 173..258
FT /note="Strictosidine synthase conserved region"
FT /evidence="ECO:0000259|Pfam:PF03088"
FT REGION 422..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..595
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 595 AA; 65106 MW; 7465A4B67A815021 CRC64;
MGFLYRVRVR VINCLIFFFL IVLLPGLPPK TTFPFEGFRF SKPRELKGAL EPTNHLDNAE
RLFEGKIYGP EALLVHGKDL FTTIHGGEVI RINGEHITHI AKFGKPCELS FEEETCGRPL
GLAFDTKGSN LIVGDAYYGI WLVDLTTGNK EQLVSPDTVL EGKGANRKGK FFNSVAVARN
GDIFWTDSSS DFTLQDGVFT IFANPSGRLF QYDRATGKNK VLLDRLYFAN GVALSPNEDF
VLVAETMASQ IRRYYLTGPK AGTDDIFIDG LPGLVDNLVA DAEGIWAPLI QAADNENPSI
PQMLSNVPLI RKFLIRMLAL AELPMRMIHQ VMPNVHTQRI IHAIGHFESL IFFAPNRQTL
VKISWNGRIL GSLHGFDGSV GSVSHVAELG DYLYLGSPYN KFLARVPLPK MPKVEIRDVK
YKPATETTAA PKPTTTTTTT PKPTTTTTTT PKPTTTTTTT TTPKPTTTTT RKPATTTTPK
PATTTTTTPK PTTTTPKPTT TTPKPTTTTT TTEKPKTTPT PKATTTTPKA TEAPKASTEE
PVKAKKADKK TPPPASSKET PSEPAPIHEK VPNDTPKPKQ EKLKVIKKGG EQGEL
//
