ID Q7PUP4_ANOGA Unreviewed; 1345 AA.
AC Q7PUP4;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 5.
DT 24-JAN-2024, entry version 126.
DE SubName: Full=AGAP002024-PA {ECO:0000313|EMBL:EAA01233.6};
GN ORFNames=AgaP_AGAP002024 {ECO:0000313|EMBL:EAA01233.6};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA01233.6};
RN [1] {ECO:0000313|EMBL:EAA01233.6}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA01233.6};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA01233.6}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA01233.6};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA01233.6}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA01233.6};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA01233.6}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA01233.6};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA01233.6}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA01233.6};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004283}.
CC -!- SIMILARITY: Belongs to the FCHO family.
CC {ECO:0000256|ARBA:ARBA00011064}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA01233.6}.
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DR EMBL; AAAB01008987; EAA01233.6; -; Genomic_DNA.
DR RefSeq; XP_321030.5; XM_321030.5.
DR STRING; 7165.Q7PUP4; -.
DR PaxDb; 7165-AGAP002024-PA; -.
DR GeneID; 1281093; -.
DR KEGG; aga:AgaP_AGAP002024; -.
DR VEuPathDB; VectorBase:AGAP002024; -.
DR eggNOG; KOG2398; Eukaryota.
DR HOGENOM; CLU_007107_0_1_1; -.
DR OMA; XKFQDIE; -.
DR OrthoDB; 2996449at2759; -.
DR PhylomeDB; Q7PUP4; -.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR CDD; cd09265; AP_Syp1_like_MHD; 1.
DR CDD; cd07648; F-BAR_FCHO; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR028565; MHD.
DR InterPro; IPR018808; Muniscin_C.
DR PANTHER; PTHR23065:SF15; AT02057P; 1.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF10291; muHD; 1.
DR SMART; SM00055; FCH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 3..259
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 1033..1301
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
FT REGION 275..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 148..187
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 276..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1310..1345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1345 AA; 145465 MW; D414C151EDB518B9 CRC64;
MTVDFNDYFW GEKNNGYEVL YQNMKYGLSA TKELAEYFRE RSNLEEYNSK LLTKLANKAG
SSGGGTFSPL WIILKSTTER LSELHAQKVQ KLTELVKNVT KYAEDLHKKH KSVKEEESGT
QDAVQAMKES TAAVAKAKDT HNARLQEVEK ARKDNSAKEI EKSEAKLRKH QDDYKALVEK
HNIIKQEFEK KMTITCRRFQ EMEEAHLKQM KEFLSSYMDI VQNNFDLVGQ VHSDLKRQFL
ELTVDKLLEQ FVLNKYTGLE KPELIELDFE SGTASGSGAV GHNSGHQLLV NTSAPLPPGG
SISPAPSSLA GGGLLESPTL SATSSSQPIN IGTAPGKKES SHLRSWFSSS STAAVPTNSP
VNLSTSPTST SMGGGGGRWG DGGTELSSAQ QQPHPASLRA MSPVPSVLNE SSVSGSAQST
GKQSSKPFYG DLFSFKHHST NPSTNHNQPY HHPPNLATNG HNNGGSGKQQ SQQSPQMKQQ
EQQLQESLQH PQQQQDQQQQ QPASPQQLPP PQQQQQQQKS SRRTTSLLNL FMSNSQGSRD
SRESRESTTS SAGGRRNNSN IAGGTNAAAS EVGRNSVSST GATVSAPTSP NDPDTGSSGG
GTAAAIDERS QQQQSFIGRN PLLRGSKSVS GFLRSRREKA KSKKAKKKKD STENSSAKDE
NILDGYVDSK GDTANTDSAT NLQTTSAISA SNVAPTATPE VDEDGYSIQP RETTWDSATI
TEKSNNFYSS SDSDSEDERE EKKIHVEIKP LNNGAAPISA SVDELRATVE NLSLSPIGIL
TSARRGSSFD PQHQDRLLRM KRSKSVSQQI GDNGNGCKPS HDLLSLNHSI FQQQQQQQHH
QQHQLHHQLH HQQQQQTQPA SQAHALHHQM SVGNASLLNN SNAATHLTSP NASNASTPTT
VHPYAPLQSP TLSMSTSSNN RYADLGDIFS EVGDISISAP TSANLTKLTQ RQIPTPTSAG
GSSIAIPRPP SRRSEAAGKG AGEPCPFIAR DRVSPASQIA RADSVGSLEF RSPSVGIGSS
RGPSPLTIGM SDTIPLAVAF HEIIHAYFKG ADESRCQVKM SGDMMISFPA GIVNVLTNNP
NPAKLGFRIK NLQNLDNVLP NKQLITIDRL QSTSFSTTLE FNMPVLTATL RRQSEQNPNA
PHINVDILKY QIKAKPGAAS CPFQLVSYWK CEQRHTDIKI DYKYNCHAMA QPSPLLNVSI
SVPVDGGVKN VQSKPHSAWQ GESNRLVWNF TDISQHSESG GVDTLRARLE VGTGPSTPAI
ISTQFNCEGT TLSGIEFELA GSGYRLSLVK RRFVSGKYIC EGDGIRTVKT PTPPNVSGVM
SPIPFGSSSS NSSKSANPSS GGTTG
//
