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Database: UniProt
Entry: Q7PXE7_ANOGA
LinkDB: Q7PXE7_ANOGA
Original site: Q7PXE7_ANOGA 
ID   Q7PXE7_ANOGA            Unreviewed;      1151 AA.
AC   Q7PXE7;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 5.
DT   20-DEC-2017, entry version 104.
DE   SubName: Full=AGAP001369-PA {ECO:0000313|EMBL:EAA01396.5};
GN   Name=1281810 {ECO:0000313|VectorBase:AGAP001369-PA};
GN   ORFNames=AgaP_AGAP001369 {ECO:0000313|EMBL:EAA01396.5};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA01396.5, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|VectorBase:AGAP001369-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP001369-PA};
RX   PubMed=9087549; DOI=10.1111/j.1365-2583.1993.tb00131.x;
RA   Beard C.B., Hamm D.M., Collins F.H.;
RT   "The mitochondrial genome of the mosquito Anopheles gambiae: DNA
RT   sequence, genome organization, and comparisons with mitochondrial
RT   sequences of other insects.";
RL   Insect Mol. Biol. 2:103-124(1993).
RN   [2] {ECO:0000313|EMBL:EAA01396.5, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA01396.5,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M., Wides R.,
RA   Salzberg S.L., Loftus B., Yandell M., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A., Liang Y., Lin J.J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z., Unger M.F., Walenz B., Wang A., Wang J.,
RA   Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [3] {ECO:0000313|EMBL:EAA01396.5}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA01396.5};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:EAA01396.5}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA01396.5};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [5] {ECO:0000313|EMBL:EAA01396.5}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA01396.5};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5-R5(2007).
RN   [6] {ECO:0000313|EMBL:EAA01396.5}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA01396.5};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|VectorBase:AGAP001369-PA}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP001369-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   EMBL; AAAB01008987; EAA01396.5; -; Genomic_DNA.
DR   RefSeq; XP_321772.5; XM_321772.5.
DR   STRING; 7165.AGAP001369-PA; -.
DR   PaxDb; Q7PXE7; -.
DR   EnsemblMetazoa; AGAP001369-RA; AGAP001369-PA; AGAP001369.
DR   GeneID; 1281810; -.
DR   KEGG; aga:AgaP_AGAP001369; -.
DR   VectorBase; AGAP001369-RA; AGAP001369-PA; AGAP001369.
DR   eggNOG; KOG2642; Eukaryota.
DR   eggNOG; ENOG41110CD; LUCA.
DR   InParanoid; Q7PXE7; -.
DR   KO; K05627; -.
DR   OrthoDB; EOG091G05ZV; -.
DR   PhylomeDB; Q7PXE7; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0051764; P:actin crosslink formation; IBA:GO_Central.
DR   GO; GO:0051017; P:actin filament bundle assembly; IBA:GO_Central.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007009; P:plasma membrane organization; IEA:InterPro.
DR   GO; GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IBA:GO_Central.
DR   GO; GO:0030838; P:positive regulation of actin filament polymerization; IBA:GO_Central.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR013606; I-BAR_dom.
DR   InterPro; IPR027681; IRSp53/IRTKS/Pinkbar.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR14206; PTHR14206; 1.
DR   Pfam; PF08397; IMD; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS51338; IMD; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
KW   ECO:0000256|SAAS:SAAS00963533}.
FT   DOMAIN       30    184       IMD. {ECO:0000259|PROSITE:PS51338}.
FT   DOMAIN      288    349       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   COILED      683    735       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1151 AA;  130360 MW;  76D7D93889EAEBD0 CRC64;
     MERLLRRTSL TRHSPRSPSM HNREEPSILL KAFYVDLLVP LETNLEKDTK VVQFEQKKFL
     QQHKMRSDSY SKAAATMKKY RKKNSKNTPK EAEKEIKSIQ AFEEEKHKLD QFCEQSLKNA
     MTQERRRYGF VLERQCSLAK HWMAYHHSGH MIIEKSLDNW NDVAATREFL PPNVENMFSA
     KQALRDVEDE DDDDRESIAS QLRKTRSIDA SCLDMRSLAD VANSTLQMPR AKSEFNLNNN
     TGTLLSGHHH HHHHHNHHAM MMMGGGGGGG AGSMIGGATN GKPDISHWER PTVKALYAYL
     SSGENQLSFL EGDRIALVGD RAKGWQFGEN LRTQKFGWFP IAYTETERDD KESISEWVKA
     PASDIELDHT PDTSLESTLV DDSLSKMTGS YHGGEDASPT RMFGDTIQYR QSKQFRRLSR
     GEKPPKPGPP PQLPAPVPTP VVPNSYSGGG SKQQQQQRHD GASGSGGIPQ SNSFSSAGAP
     PMASDKRKSG SATMNFSKPP ASSNPKQKRA SNGMASASLH SSNDSGFSNE PQPQPEADLY
     SDEEPVNRVP IRSARSEKNL LNDQTTMTRS GGRDSSVPSP RYHDEDDIYG TIVPPRPRGQ
     QSQMMMRQAN SYGNIAESNS GTLEYGYRTR NRGSGSEGQP NQSDSQKIKR TKSFWKFSKS
     EDHILEGMAM WKHNDIIPTG REKREMEKKE ATLKRNMRKK EQLEKQKQKE MIAAKAEEEQ
     QQQQQQRRKD NSRGNANGMM DNESNTSTLV RGNNRESRDR DRDQRGEPMR ERPHSIALMS
     EQEKFPITKS DIDKRISKID QEFHQQQKKA SRGGQEEDRG GRSGRDRGEG GDRKQSKGGK
     NDTNNNNNNS RHSYAGEHLH PQEQELYGEA PMGGGKHGGK QDKYRTTERE TSKNRNNDAL
     NKYYQDQTFD DFSIIPADSI MMQDTSFYDD DGMMDDMMLM KTVRRKEILK QYYSSGTDTE
     RNSSSSDPYD CIVVDDHLVA KGRDRKSNGG QDGTMMRMMN DRRGDKKDRG MPDDKMAFST
     FRGGVSGGNG GRGQLDDDDD DTMMASMTLD DELMEEEQQQ QHHHQQQQQQ QQSRQQQTRD
     RRSKSSKGNL AESKYESEHE ARISAKMQSN GQQQQQQQKR KSTKSIASDG KAYGPWYDLW
     GADSSVHNQK L
//
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