ID Q7Q2Y4_ANOGA Unreviewed; 1241 AA.
AC Q7Q2Y4;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 4.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=AGAP011395-PA {ECO:0000313|EMBL:EAA13037.4};
DE Flags: Fragment;
GN ORFNames=AgaP_AGAP011395 {ECO:0000313|EMBL:EAA13037.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA13037.4};
RN [1] {ECO:0000313|EMBL:EAA13037.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA13037.4};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA13037.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA13037.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA13037.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA13037.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA13037.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA13037.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA13037.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA13037.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA13037.4}.
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DR EMBL; AAAB01008966; EAA13037.4; -; Genomic_DNA.
DR RefSeq; XP_317925.4; XM_317925.5.
DR AlphaFoldDB; Q7Q2Y4; -.
DR STRING; 7165.Q7Q2Y4; -.
DR PaxDb; 7165-AGAP011395-PA; -.
DR GeneID; 1278302; -.
DR KEGG; aga:AgaP_AGAP011395; -.
DR VEuPathDB; VectorBase:AGAP011395; -.
DR eggNOG; KOG1935; Eukaryota.
DR HOGENOM; CLU_002506_1_0_1; -.
DR OMA; HLYDTEW; -.
DR OrthoDB; 1219406at2759; -.
DR PhylomeDB; Q7Q2Y4; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF1; PROTEIN PATCHED; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 382..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 861..881
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 888..907
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 913..938
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 950..973
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 985..1011
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 380..535
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1051..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1162..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAA13037.4"
SQ SEQUENCE 1241 AA; 139735 MW; 89A4DE77725300CD CRC64;
GKARGRRSSV YMRSLFQSYL YNLGCSIQKH AGKVLFVAIL VLSTFCVGLK SATVHSKVHQ
LWIQEGGSLE HELAYTQKSL GEMDSSTHQL LIQTPKDMDA SILHPNALLT HLDVVKKAIS
VTVHMYDITW SLKDMCYSPS IPSFDTHFIE QIFENIIPCA IITPLDCFWE GSKLLGPKYP
VHIPGQTNKV QWTSLNPQTL LKDIKAQNYQ FPFETLEQYM KRAGISTGYT EKPCLNPKDK
QCPDTAPNKK SGQVPDIGAS LTGGCYGFAA KYMHWPEELV VGGAVRNRTH HLRSAKALQT
VIQLMGEREL YDYWNNHYKV HHIGWNPDKA AEVLNAWQKK FSAEVNKIMQ TEVKPLSYYG
VYAFSSATLD DILGKHSNPN PISLGIGIAI ILLYTACTLL RWKDGINGQS GVGVAGVLLI
TVTTAAGLGF CALLGIAFNA ATTQVIPFLA LGLGVDHIFV LTHAYAERDT SEQTGQVLKK
AGLSVLFAGA STAGSFFAAT LIPVPALRVF CFQGAILTVF NLAAVLLVFP AMISLDLRRR
RSGRADRNAT RKRHIECQSK SCLSFSLSRF AIKHYAPFIT RSSVKVFGML LLSGILGVSL
FASMKLPDGL ELTDLVPQNT NEHRFLSVQG KLFGFYSMFA VTQGDFEYPN NQKLLHEYHE
AFVRVSHVIK NDNGGLPDFW LSLFRDWLVN LQRAFDRDYR EGRITQERWY SNASNDAILA
YKLLVQTGHV DNPIDKSLVT QVRLVDSEGV INPEAFYNYL SAWAWNDVLA YGASQGNLRP
EPREWFHTPS DFELKIPKSA PLTYTQLPFY LHGLSDTADI KTMISQIREL CSRFESRGLP
NYPSGIPFIF WEQYMNLRPG LLKAIGCALL AVFVFVSLLL LSGWAALLIV LNVLMMQIQL
LGVMILLGIK LSAIPAVILI ASIGLGVGIT VHVALGFITS IGNRDRRVKL ALEHCFAPIV
HGVITSALAI FMLSTSSFEF VVRHFFWLLL SAVLIGAVNG LFFFPILLSL VGPGAEIIPL
QYANRISTPS PPPKRINKLS SGKPIVLNNK RSSCSRSCTK PHHHHKHNNV NLSNEPSLTT
ITEEPQSWKS SASSIPSIHE KTTGGSSMGH HRSLSGMVGG GGGIGGVTTH HHGGDHQNTK
VTATANIKVE LWRREEKEER ERERERERER ERERERKRKR ERERERERER ERERERERER
ERERERERER ERERERERER ERERERERER GIYIMKEKKH T
//
