UniProt: Q7Q4I0

Database: UniProt
Entry: Q7Q4I0_ANOGA

LinkDB:  Q7Q4I0_ANOGA 
Original site:  Q7Q4I0_ANOGA

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Ontology (2)   
   GO (2)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (24)   
   InterPro (12)   
   Pfam (6)   
   PROSITE (1)   
   SMART (5)   
Literature (3)   
   PubMed (3)   
All databases (33)   

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ID   Q7Q4I0_ANOGA            Unreviewed;      1786 AA.
AC   Q7Q4I0;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 4.
DT   27-MAR-2024, entry version 124.
DE   SubName: Full=AGAP008407-PA {ECO:0000313|EMBL:EAA12257.4};
DE   Flags: Fragment;
GN   Name=TEP13 {ECO:0000313|EMBL:EAA12257.4};
GN   ORFNames=AgaP_AGAP008407 {ECO:0000313|EMBL:EAA12257.4};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA12257.4};
RN   [1] {ECO:0000313|EMBL:EAA12257.4}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA12257.4};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2] {ECO:0000313|EMBL:EAA12257.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA12257.4};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:EAA12257.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA12257.4};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [4] {ECO:0000313|EMBL:EAA12257.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA12257.4};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5.1-R5.13(2007).
RN   [5] {ECO:0000313|EMBL:EAA12257.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA12257.4};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAA12257.4}.
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DR   EMBL; AAAB01008964; EAA12257.4; -; Genomic_DNA.
DR   RefSeq; XP_317044.4; XM_317044.2.
DR   STRING; 7165.Q7Q4I0; -.
DR   PaxDb; 7165-AGAP008407-PA; -.
DR   GeneID; 1277572; -.
DR   KEGG; aga:AgaP_AGAP008407; -.
DR   CTD; 1277572; -.
DR   VEuPathDB; VectorBase:AGAP008407; -.
DR   eggNOG; KOG1366; Eukaryota.
DR   HOGENOM; CLU_001634_5_1_1; -.
DR   InParanoid; Q7Q4I0; -.
DR   OMA; IDSAFYT; -.
DR   OrthoDB; 2970602at2759; -.
DR   PhylomeDB; Q7Q4I0; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd02891; A2M_like; 1.
DR   CDD; cd00112; LDLa; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 2.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 2.60.40.2950; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF179; LD23292P; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM00192; LDLa; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF57424; LDL receptor-like module; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00124}; Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT   DOMAIN          683..817
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          955..1046
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   DOMAIN          1632..1723
FT                   /note="Alpha-macroglobulin receptor-binding"
FT                   /evidence="ECO:0000259|SMART:SM01361"
FT   REGION          1..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        902..920
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        914..929
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EAA12257.4"
SQ   SEQUENCE   1786 AA;  204058 MW;  B5611EE51B522904 CRC64;
     AQQSQPQSND VNRYNPQDPF GGRQQYNPQY PSSQYDPNTR TNQGLPPSQS SGTNYQRDYY
     GNNAVNGNNQ DSNSIDSNRF GQDNRNVVLQ STTPRDYFNR QTTPPFRTRT SNRNPFSNND
     YAAGNSFSQG ITYFIVASKM VRPGQVYKVA VSVLESHLPL TVRTSISRDG VELSSETKPI
     TVGVPETMLM RVPPTSVVGE YKLRVEGSYD KNFGGYVFAN ETKLIFSQRS MTIFVQTDKP
     VYMQGETVRF RAIPITTELK GFDKEMNVYM LDPAGHIMRR WLSRQSNQGS VSLQYQLSDQ
     PVFGEWKIRI EAQGQIEEAR FNVEEYYQTR FEVNVTMPAF FFNTDRYIYG RIMANFTNGT
     PVKGNLTLKA TIRPIGFFNP EAINQMNRVG NLGRLTNLNQ NVPYYLQKTN PDLLNQYNPQ
     NSFSSQIGGR DQGGYDGVGQ GYDGRYSSNN FQDSYVIERH LNFDEEWPFW IKKPVESDSQ
     WDSWTNTYRD SLPYLRFFNG TYNFRFPMAE LAQLVPNLSG MEILFTARVG ERYYNEIVEG
     YSLTRVYNSS IRIAFLGDSP QVFKPSMPFT VYLIAEYHDG SPLPLDEFNA GRMEVSGTID
     SRASGGRNSF DSRVLHMSQK AGVWELKLDI RHDLNLENTK QTNEFLNEIQ SMRLVANYID
     PSGERASTEL LLLSHFSPNN HNIKVHTSTA DAKVGEYITL HVQSNFYIKD FNYLVMSKGI
     ILVTGHENMK GGVKTMAITL SAEMAPAATI VVWHIGRYGK LLTDSLTFPV NGISRNNFTV
     FINNRKARTG EKVEVAIYGE PGSYVGLSAI DNAFYTMQAG NELTYANVIQ KMLSFDEHTN
     GTFKKTWMSH DGDPDELVYY PASTFGIDAN RTFDYAGLVV FTDGVVPMRP TICDAALNYS
     ECLNGRCYRT DKRCDGYMDC EDGTDEAGCS TRNETLLVEF RKFRFNRILR HYQNVWLWKD
     VNIGPHGRYI FNLDVPQVPA LWSVSAFGIS GTRGYGMIRK PIEYVGIQPF FINVEMPTAC
     HQGEQVGIRV AVFNYQTVDI EATVVLHSSP DYQFVHVEED GIVRSYNPRT SFGEHQFYIY
     LNAQDSTNVY LPIVPTRLGE IEVTIHASTL LGAHQISRKI TVEADGLPQY RHQSILLDLR
     NRAYLVQFMH VNVTETPIIP YEIDRYYVFG SNRARISVVG DVVGAIFPTM PINTTSLLEL
     PMDAAEQNMF SFAANFYTIK YMRASTLRDK RTEKQAFHFM NILYQRQLSY LMEDGGFSLF
     RADWNQSAPS VWLTAYCAQV FGEMAGLYEY ENFIFIDPYM IQKNMHWLLR HQKEDGSFWE
     ETWLPDRKAN SSAFFSRNDV VREKNVTLTA HVLITLTTVN LPAGRLAARV ALSQQRALQY
     LQRNLATIKE SGSTYEIAIV AYALMIAKAP KAEAAFTMLS AKMRSIGEFN YWGEEEVPLP
     PTKLENQRYF SLPRLPYKYD SLNIQTTAYA LLTYVSRQEI HVDPIVAWLN AQRLTDGGWA
     SSQDTGMAMK ALTEYSTRNR VSNVTQLAIK VEATSLPGET KQLYITRKSL AQQQFLDVPN
     AWGTVRVEAT GVGYAILQMH VQYSVDTYKF QTQPPVPAFD LTTRTIFHGR NQSHISYVIC
     QRWINTQESI RSGMAVLDVA VPTGYMIQQQ KLDSYILSQR VRNLQRARFQ ERKVLFYFDY
     LDNDYVCVNF TLERWMPVAN MSRYLPIRVY DYYAPERFNE TIFDSLQTYL LNICEVCGSS
     QCPYCSIYNI AVRFPGSIVL MLLTGIVLVA RHYRIVNPNG WIFLND
//

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