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Database: UniProt
Entry: Q7Q9F5_ANOGA
LinkDB: Q7Q9F5_ANOGA
Original site: Q7Q9F5_ANOGA 
ID   Q7Q9F5_ANOGA            Unreviewed;      1196 AA.
AC   Q7Q9F5;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 4.
DT   25-OCT-2017, entry version 115.
DE   SubName: Full=AGAP005251-PA {ECO:0000313|EMBL:EAA09546.4};
DE   SubName: Full=Potassium voltage-gated channel {ECO:0000313|VectorBase:AGAP005251-PA};
GN   Name=1274964 {ECO:0000313|VectorBase:AGAP005251-PA};
GN   ORFNames=AgaP_AGAP005251 {ECO:0000313|EMBL:EAA09546.4};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA09546.4, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|VectorBase:AGAP005251-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP005251-PA};
RX   PubMed=9087549; DOI=10.1111/j.1365-2583.1993.tb00131.x;
RA   Beard C.B., Hamm D.M., Collins F.H.;
RT   "The mitochondrial genome of the mosquito Anopheles gambiae: DNA
RT   sequence, genome organization, and comparisons with mitochondrial
RT   sequences of other insects.";
RL   Insect Mol. Biol. 2:103-124(1993).
RN   [2] {ECO:0000313|EMBL:EAA09546.4, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA09546.4,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M., Wides R.,
RA   Salzberg S.L., Loftus B., Yandell M., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A., Liang Y., Lin J.J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z., Unger M.F., Walenz B., Wang A., Wang J.,
RA   Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [3] {ECO:0000313|EMBL:EAA09546.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA09546.4};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:EAA09546.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA09546.4};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [5] {ECO:0000313|EMBL:EAA09546.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA09546.4};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5-R5(2007).
RN   [6] {ECO:0000313|EMBL:EAA09546.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA09546.4};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|VectorBase:AGAP005251-PA}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP005251-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   EMBL; AAAB01008900; EAA09546.4; -; Genomic_DNA.
DR   RefSeq; XP_314166.4; XM_314166.4.
DR   ProteinModelPortal; Q7Q9F5; -.
DR   PaxDb; Q7Q9F5; -.
DR   EnsemblMetazoa; AGAP005251-RA; AGAP005251-PA; AGAP005251.
DR   GeneID; 1274964; -.
DR   KEGG; aga:AgaP_AGAP005251; -.
DR   VectorBase; AGAP005251-RA; AGAP005251-PA; AGAP005251.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   HOGENOM; HOG000230794; -.
DR   InParanoid; Q7Q9F5; -.
DR   KO; K04911; -.
DR   OMA; SHPPEVW; -.
DR   OrthoDB; EOG091G0OXR; -.
DR   PhylomeDB; Q7Q9F5; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01465; ELKCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    268    287       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    390    416       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    481    505       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       37     89       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN       92    144       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      583    647       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   1196 AA;  133412 MW;  184C5227D50BE471 CRC64;
     MPARKGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVNGYP IVYCSDGFVE LSGFSRAQIM
     QKGCACRFLY GPETKDEHKS MIETSLDGKS ELKLEVIFYK KNGTPFWCLL DIVPIKNEKR
     EVVLFLASHK DVTTAKMSEM SMSDECDSGN VCFLINSILS TFTPVEILAA LLGARFRSAE
     TSLLADDGAE DDSLEIPPGV NMGRRRSRAV LYQLSGHYKP EKMKTKIKLN SNLLHSSEAP
     LPEYKTQALK KSRFILSHYG MFKGCWDWMI LVATFYVAIA VPYNAAFVKT DRLTMVSDVV
     VEALFIVDIL VNFRTTYVSR KGEVVSDSKS IALNYLRSWF VVDLLAALPF DHLYASNVIS
     GEESHIHLVK LTRLLRLARL LQKMDRYSQY TAMILTLLML CFSLVAHWLA CVWFVIAEKE
     RLMNDADWDI GWIHTLAERL KIPVSNVTHG EAYITALYFT FTSLTSVGFG NVSATTLSEK
     IFSIIMMLIG ALMHAVVFGN VTAIIQRMYS RRSLYQSKWR DLKDFIALHQ MPKELKQRMQ
     DYFQTMWSLN HGIDVYEILK EFPEELRGDI SMHLHREILQ LPIFESASQG CLKLLSLHIK
     ANFCAPGEYL IHKGDALSYI YYICNGSMEV MQNNMVVAIL GKGDLVGCDI SIHLLHGNQG
     NSGNTGSQDT IVKSSGDVKA LTYCDLKSIH MSGLVEVLRL YPEYQQEFAN DIQHDLTYNL
     REGYEAEEET ENNGPCLALP SISEDDENQS DAETSSASPM NTALQKSPAH NVGSSPRHAK
     LVHSRNRSLV ALRERVERQR SVQTASQPPT VEQANSFEGL NLEVAKEKEK GRMSVERLDN
     QVTTLHNDVA ALSVEVRNAI HALQEMTYNT MNSQLDLGHF QPARSIPNLQ NGAVGILRDS
     DHVLMARSSS HPPEMWCREM NVFAEGGIAS PNGTEVLSEA MYRRKSILSQ KYSEEMSSST
     QTENMIDFDT LEKVVLAHPH LVLKILGVEA VFGKESDHLA KSYPLNTISE VASSGETISS
     RVQDTVPTYK LPPFLTNTNI ISNPPATHHH QCELDGQLYD HRALIDAYHQ EGDFYSAPSS
     ACAKEDNCDN ISNATTTTPP PPPPPPPPPP LPSLLSAPSN PHDVPLLGTE GGRAPVPDTD
     CILVDENVNV LKQSAMNHIF RKQDRVPPNY RFSAGDADHL EKGLRNLPSS RSLGGS
//
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