ID Q7QGY6_ANOGA Unreviewed; 1073 AA.
AC Q7QGY6;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 4.
DT 27-MAR-2024, entry version 117.
DE RecName: Full=Gamma-tubulin complex component {ECO:0000256|RuleBase:RU363050};
DE Flags: Fragment;
GN ORFNames=AgaP_AGAP010956 {ECO:0000313|EMBL:EAA05519.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA05519.4};
RN [1] {ECO:0000313|EMBL:EAA05519.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05519.4};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA05519.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05519.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA05519.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05519.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA05519.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05519.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA05519.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05519.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center {ECO:0000256|RuleBase:RU363050}.
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337, ECO:0000256|RuleBase:RU363050}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA05519.4}.
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DR EMBL; AAAB01008823; EAA05519.4; -; Genomic_DNA.
DR RefSeq; XP_309751.4; XM_309751.4.
DR AlphaFoldDB; Q7QGY6; -.
DR STRING; 7165.Q7QGY6; -.
DR PaxDb; 7165-AGAP010956-PA; -.
DR GeneID; 1271009; -.
DR KEGG; aga:AgaP_AGAP010956; -.
DR VEuPathDB; VectorBase:AGAP010956; -.
DR eggNOG; KOG2000; Eukaryota.
DR eggNOG; KOG2001; Eukaryota.
DR HOGENOM; CLU_005451_0_0_1; -.
DR OMA; EQFQECQ; -.
DR OrthoDB; 2914784at2759; -.
DR PhylomeDB; Q7QGY6; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF70; GAMMA-TUBULIN COMPLEX COMPONENT 6; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363050};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|RuleBase:RU363050};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU363050}.
FT DOMAIN 9..260
FT /note="Gamma tubulin complex component protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17681"
FT DOMAIN 759..1065
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
FT REGION 419..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 302..363
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 419..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAA05519.4"
SQ SEQUENCE 1073 AA; 123586 MW; 035AFEFCBCDE83A0 CRC64;
ERNRFRALPN ITIEDVRIES IQSFVEQALE IGTCFRRLLM MTRKNPYTLE LIMEGFVFRA
FCESVENFLC CYRVLVNSYA GESILQLLQM LSPANEQLLS MAKLCSLHPG NESDREFPTG
SMLLDHLYRE LIQVTQPSVS VFLLSTLRRC CLEYFAIFQR WLFQGQLHDP SGELFVFFVD
HYRSNTKHFF DKAYFIRRKS VPGFLKGYDE DILLCGKYVM LLRAFRPLHP LFTLRHPELT
VCLSFAEIQT MRTQWLRYVA KARQLCGPAV SVRELYETKQ SEQVEFYRLV EENFRTYMDA
WRVEQETEAQ EQKRRKQKQM ADLLDHLNEI RESKLLAKRA ELQEELALEQ ARIEQENRQL
LGENLELTGR VKNIVPVVTV TVDGTDGTVS EEAPFESCRE SRASNVTSVS IYEDAQKSPA
CSVDSSPYGA DSTSSYGSAG KGDLSTSGAE DLDCTLVEGP IVPTVESPAA VLDSDRLNSN
VPAVSEGERN RAKVLGSTVG DFLNEDHANA NVEQLVRRKN RERILISDYT SREEEAAPGG
QPVPGRELSE LQKNRRKIMS QEYNLLTDEA VWDGTGGRDP NQKRTMYLNL DSDRARNRRR
ILESEFDIAT GVENFPASPM SVDSDTVDES ASPSLAMTAS GTTPTITGEQ DVNANPVAGK
GAGLKLDLTE EEDDEIYREF VAAMKQQSEN FCRLAIPTSD SDTSAHVGAS KALEKELNSV
DVLTITRFLQ YSLVIPLKAH MEIVHNEILK MYLYDLDVLG HFESLRNYFL LMDGEFSTHI
CDNLFQRLET VRTPEELLNY QTLHSILDGA LYSSNAGTDR NADRLSFIVC QVPEKFDLYS
PNVFSMLNLS YRVEWPLNLI FSNETIEQYT NVFKYLVKVR RVSYVLEDSF QLLKEASRRL
GKPLLHSPQY ARVQLIRHKL SHLVNALKNY ITSSALHASW ETFREDLQDA TETMEDLFRK
HRTYLKRVIF LCLLNRRSIE FYNNIEHIFR VVLRFYRHLR SKEWRLQEES QQYYVHPRYR
SMLDDEIDFE KLIKYTIFLG NKMYDHGYQK EISEFLHVIN INGYYDDVKP AAS
//
