ID Q7RXT2_NEUCR Unreviewed; 801 AA.
AC Q7RXT2;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 24-JAN-2024, entry version 101.
DE RecName: Full=Enhancer of mRNA-decapping protein 3 {ECO:0000256|ARBA:ARBA00015797};
GN ORFNames=NCU00427 {ECO:0000313|EMBL:EAA27455.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA27455.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA27455.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the EDC3 family.
CC {ECO:0000256|ARBA:ARBA00006610}.
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DR EMBL; CM002238; EAA27455.1; -; Genomic_DNA.
DR RefSeq; XP_956691.1; XM_951598.2.
DR AlphaFoldDB; Q7RXT2; -.
DR STRING; 367110.Q7RXT2; -.
DR PaxDb; 5141-EFNCRP00000000454; -.
DR EnsemblFungi; EAA27455; EAA27455; NCU00427.
DR GeneID; 3872854; -.
DR KEGG; ncr:NCU00427; -.
DR VEuPathDB; FungiDB:NCU00427; -.
DR HOGENOM; CLU_024328_0_0_1; -.
DR InParanoid; Q7RXT2; -.
DR OrthoDB; 1409462at2759; -.
DR Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IBA:GO_Central.
DR GO; GO:0033962; P:P-body assembly; IBA:GO_Central.
DR Gene3D; 3.40.50.10260; YjeF N-terminal domain; 1.
DR InterPro; IPR025762; DFDF.
DR InterPro; IPR019050; FDF_dom.
DR InterPro; IPR004443; YjeF_N_dom.
DR InterPro; IPR036652; YjeF_N_dom_sf.
DR PANTHER; PTHR13612:SF0; ENHANCER OF MRNA-DECAPPING PROTEIN 3; 1.
DR PANTHER; PTHR13612; UNCHARACTERIZED; 1.
DR Pfam; PF09532; FDF; 1.
DR Pfam; PF03853; YjeF_N; 1.
DR SMART; SM01199; FDF; 1.
DR SUPFAM; SSF64153; YjeF N-terminal domain-like; 1.
DR PROSITE; PS51512; DFDF; 1.
DR PROSITE; PS51385; YJEF_N; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT DOMAIN 279..315
FT /note="DFDF"
FT /evidence="ECO:0000259|PROSITE:PS51512"
FT DOMAIN 487..767
FT /note="YjeF N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51385"
FT REGION 122..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 801 AA; 86780 MW; EB582F2E9F6209A3 CRC64;
MAEDSFIGLP MLVTMRNPPA RLKGTVSEVQ AGHGLTLTNV WNVDNNRWEP RVSILSSNIV
DIVYLREDPS PQTAVPPPVP PPHVIPPPHA VPHAIPQVAP PVAQPPPPTK PAAFVDPAIL
SVGKRPGSLS GHASDTSRHQ PNTSEKRDPT PAVVPSNNAV PIPSGTATPT LPVVDRLRRL
ELDAQTSTQE SADEDLAPDA SSQQAAAAAQ KKKNRRPRRT GNNSRSGLQE DSEASPQVSR
ATTKGKGWRQ TPILQSTSSF QPFNSLKKMR GANDNGWASE DVTDVQEAGD FDFESGLAKF
NKQDLFEQMR KDDLIDEADR LVSHNRVPKH KPGTAGGKNL HHSENVLDMP STILKPKLIV
KETSNDFWNS EADDGVINGA DRLSGRDQAS RQGSRRGDSK VASNRRSNSR KASGVPAAHP
LSRVNSSGVS HYRTLSAKGS RPSSRLSARA AVVDKKKQPA TTVAASPQGL YVLPSNRKIE
PVSALQMLNL ENIAHNEIGL TEEMMTENAG RGIAEVTLTA LSDPAIKVRH SSIVDPTSGN
PPPPTVVVLA GNNKSGIRAV AAARHLRNKN ISVIVCVVGL ERGERDLLED MRQQVRLYKN
MGGRIFSKSD FFEHLRKISI PMLTIDTPRS SLSSLANPAP IMLIIDALLG LAISFDELRN
GDQATVYELI EWANRNEAFA LAVDIPTGID PSTGKVSVVD GNKLYVKPRY VVAVGAPKRG
LLEALMVAEN DDGDTVLAGG DTSLPDDAVL EWKLYLVDLG LGPAMWKKAG TKMRRGIDFE
DRWVVEMKYR GLAEEEEEEL V
//
