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Entry: Q7S2C4_NEUCR
LinkDB: Q7S2C4_NEUCR
Original site: Q7S2C4_NEUCR 
ID   Q7S2C4_NEUCR            Unreviewed;       879 AA.
AC   Q7S2C4;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2003, sequence version 1.
DT   24-JAN-2024, entry version 120.
DE   SubName: Full=Rho-GTPase-activating protein 8 {ECO:0000313|EMBL:EAA29520.1};
GN   ORFNames=NCU09537 {ECO:0000313|EMBL:EAA29520.1};
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA29520.1, ECO:0000313|Proteomes:UP000001805};
RN   [1] {ECO:0000313|EMBL:EAA29520.1, ECO:0000313|Proteomes:UP000001805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC   {ECO:0000313|Proteomes:UP000001805};
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA   FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA   Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA   Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA   Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA   Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA   Lander E.S., Nusbaum C., Birren B.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
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DR   EMBL; CM002240; EAA29520.1; -; Genomic_DNA.
DR   RefSeq; XP_958756.1; XM_953663.2.
DR   AlphaFoldDB; Q7S2C4; -.
DR   STRING; 367110.Q7S2C4; -.
DR   PaxDb; 5141-EFNCRP00000007599; -.
DR   EnsemblFungi; EAA29520; EAA29520; NCU09537.
DR   GeneID; 3874903; -.
DR   KEGG; ncr:NCU09537; -.
DR   VEuPathDB; FungiDB:NCU09537; -.
DR   HOGENOM; CLU_008201_1_0_1; -.
DR   InParanoid; Q7S2C4; -.
DR   OMA; NPFTRWC; -.
DR   OrthoDB; 1328399at2759; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0000935; C:division septum; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IBA:GO_Central.
DR   CDD; cd04436; DEP_fRgd2; 1.
DR   CDD; cd04399; RhoGAP_fRGD2; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          2..438
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          214..298
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          472..669
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          163..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          681..879
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          111..142
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          351..378
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        184..199
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        695..715
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        748..765
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        846..861
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   879 AA;  97798 MW;  9ABB42FC5B8F471C CRC64;
     MPGFADSFWS NDYAAGLGVL FGKLQQGVVE NRQLLTIARM RAEAEDVYGQ RLSEIAPAVD
     KIPNGFNRDD GASVRKAYEG VRTEMEDASK NHKKIAQNIR DLVVNPFTRW CDAHESRLQN
     SQEELQAKIK AHDKQAELVK KLRSNYFNKC RLVEDLEEEN KLAFQDPESA ASPKPKQPIP
     EIKVEPEEEE DDEPYEIGDE TYSPDQIKKI LAHMLNNIKM GETKVPILGT YQNTSAGTDI
     VEYLQRHMGT TSISYAERIG QDLITHGFLR LIGNVGNTFA NSSRMSYQWR PQAFKLAGVP
     EKKAPVGRTF SMPLSNGSEG NDSPVVGVVS EYLANWNIPG VNNGRPNETP SERMRREARE
     ADEKYKAAVQ KLDEMRCELE EAIFLHLKFL ERCELDRLKA IKTVVLDFSG TISNVIPSLQ
     STVDNMMLYQ ETVQPLGDLR YLLENYRTGS FVPKVVTYEN YYNKVDEQTF GVDLEARARA
     DKKRVPIIVT TLLTYLDHHY PDLEGDEARR GVWLHEVSLK DTHKLRAKVN NGKPPSLEVF
     AEFDVPTVAS LLKLYLLELP DSLVSSHVYE IIRTIYNTTQ DSSEDARIPV LQQTLSQLRL
     TNIATLDACM NHFTRLIELT SADEEYVAKL ATTLAPCILR PRTETSLTME EKHAYRLIRD
     LFAHKDAIFS ELKRMSTLGA SATISGNNNR PRAISTDESN RRANMEERNR LILEKANGGR
     SRATSPAPGP RAHRRDRSVG GPETRFPISP SGITSPTSSQ QHGKRPSLGP VLPKRSSLEV
     PEEAGSAISH PADGNSNGAA PAEAGTPKSE TADPLADKRS SLVEKRNSLG RSGARISVGR
     RIPVVASTTA ASQQPSGTEK ENLSGGHAPV TLVDAPMDD
//
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