ID Q7S2C4_NEUCR Unreviewed; 879 AA.
AC Q7S2C4;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 24-JAN-2024, entry version 120.
DE SubName: Full=Rho-GTPase-activating protein 8 {ECO:0000313|EMBL:EAA29520.1};
GN ORFNames=NCU09537 {ECO:0000313|EMBL:EAA29520.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA29520.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA29520.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
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DR EMBL; CM002240; EAA29520.1; -; Genomic_DNA.
DR RefSeq; XP_958756.1; XM_953663.2.
DR AlphaFoldDB; Q7S2C4; -.
DR STRING; 367110.Q7S2C4; -.
DR PaxDb; 5141-EFNCRP00000007599; -.
DR EnsemblFungi; EAA29520; EAA29520; NCU09537.
DR GeneID; 3874903; -.
DR KEGG; ncr:NCU09537; -.
DR VEuPathDB; FungiDB:NCU09537; -.
DR HOGENOM; CLU_008201_1_0_1; -.
DR InParanoid; Q7S2C4; -.
DR OMA; NPFTRWC; -.
DR OrthoDB; 1328399at2759; -.
DR Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0000935; C:division septum; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IBA:GO_Central.
DR CDD; cd04436; DEP_fRgd2; 1.
DR CDD; cd04399; RhoGAP_fRGD2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..438
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 214..298
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 472..669
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 163..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 111..142
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 351..378
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 184..199
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..715
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 879 AA; 97798 MW; 9ABB42FC5B8F471C CRC64;
MPGFADSFWS NDYAAGLGVL FGKLQQGVVE NRQLLTIARM RAEAEDVYGQ RLSEIAPAVD
KIPNGFNRDD GASVRKAYEG VRTEMEDASK NHKKIAQNIR DLVVNPFTRW CDAHESRLQN
SQEELQAKIK AHDKQAELVK KLRSNYFNKC RLVEDLEEEN KLAFQDPESA ASPKPKQPIP
EIKVEPEEEE DDEPYEIGDE TYSPDQIKKI LAHMLNNIKM GETKVPILGT YQNTSAGTDI
VEYLQRHMGT TSISYAERIG QDLITHGFLR LIGNVGNTFA NSSRMSYQWR PQAFKLAGVP
EKKAPVGRTF SMPLSNGSEG NDSPVVGVVS EYLANWNIPG VNNGRPNETP SERMRREARE
ADEKYKAAVQ KLDEMRCELE EAIFLHLKFL ERCELDRLKA IKTVVLDFSG TISNVIPSLQ
STVDNMMLYQ ETVQPLGDLR YLLENYRTGS FVPKVVTYEN YYNKVDEQTF GVDLEARARA
DKKRVPIIVT TLLTYLDHHY PDLEGDEARR GVWLHEVSLK DTHKLRAKVN NGKPPSLEVF
AEFDVPTVAS LLKLYLLELP DSLVSSHVYE IIRTIYNTTQ DSSEDARIPV LQQTLSQLRL
TNIATLDACM NHFTRLIELT SADEEYVAKL ATTLAPCILR PRTETSLTME EKHAYRLIRD
LFAHKDAIFS ELKRMSTLGA SATISGNNNR PRAISTDESN RRANMEERNR LILEKANGGR
SRATSPAPGP RAHRRDRSVG GPETRFPISP SGITSPTSSQ QHGKRPSLGP VLPKRSSLEV
PEEAGSAISH PADGNSNGAA PAEAGTPKSE TADPLADKRS SLVEKRNSLG RSGARISVGR
RIPVVASTTA ASQQPSGTEK ENLSGGHAPV TLVDAPMDD
//