ID Q7S2E2_NEUCR Unreviewed; 984 AA.
AC Q7S2E2;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 2.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=P-loop containing nucleoside triphosphate hydrolase protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=NCU05936 {ECO:0000313|EMBL:EAA29544.2};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA29544.2, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA29544.2, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM002241; EAA29544.2; -; Genomic_DNA.
DR RefSeq; XP_958780.2; XM_953687.2.
DR AlphaFoldDB; Q7S2E2; -.
DR STRING; 367110.Q7S2E2; -.
DR PaxDb; 5141-EFNCRP00000001539; -.
DR EnsemblFungi; EAA29544; EAA29544; NCU05936.
DR GeneID; 3874927; -.
DR KEGG; ncr:NCU05936; -.
DR VEuPathDB; FungiDB:NCU05936; -.
DR HOGENOM; CLU_008964_4_0_1; -.
DR InParanoid; Q7S2E2; -.
DR OrthoDB; 5350357at2759; -.
DR Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF131; GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07630)-RELATED; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT DOMAIN 144..491
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 830..929
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 111671 MW; 6B8FA21E081BAB78 CRC64;
MTQTNMRRAN QHARIKREPG FQQPMPNSGL ARIDEDDNST VAHSEVERRM QRSDAPSVDT
RLAPGASVIG DMDVDGEDED DECMLMEVKT KTEVVEQDLP TPRSFVNMDR SFIGPGQALK
DFGQELKDIN DALGELQARG IQHVVSLPEL VLVGDQSSGK SSLMSAIAGL SLPRSSGTCT
RCPIHIRISR ADEWSCRVFL KEDYAFVPRN HPITLQDVTD RDRFPPWVKL DPSRQTRKEF
KTIRDRFDAE EIETLLRCAQ VAILNPSTPY RFFVPRLKNE SGQSDAARRE HLDRIKEKEA
HGEAQFSPNT VALEVKGPDL ADLNFYDLPG VFITAKRPED RFLERVVRNL TCEYISRQNA
IILWAVPMNQ DAENSFAFKL IQEMNAEDRC VGVMTKADLL PRETNGFSSW LSMLNEQAHR
TGLGYFITSR QGSDLDEQNK FEEAFFNRTA DSATMGQWPE IFEKYRDRCG IEKLKEFLSI
TLGREFSKVL PEVKQKVYNR LLRIEEQLEK YPNPPPNPEM EIMRSLAEFA TNVKTRVLQQ
EFMSQWDCLF AEPFKKRILG CKPKFNVKEP DVITIDDNSP MTTPAPLGQT PRKRSMAQDI
AMTPSKRRGH IKVEDSDRMV MSPSTSATMR GTPGPGNFPF SPGLGGGPPP RSKNLMELRT
IIRRSAIPGQ PGLVSASVYE PLYTEAARTW GPHLENFVNQ TIQFLQNEVM KILDSAFSNL
KNRAVYRESV EHMKYFMEKH KEEVRNQLNL IYNLETQRIF TKDEDALQRN KAAEKRILER
HRHFLRMAVR TGESPAIRKM EELTEEELVQ EQAKMAKELK VIGPDPYDQE ITVAAYVRGY
YLTAASRFID IVAIHIMSGL LPRVASVIDT YLHEKLGLYS RTSGSGPEIF MRLMSEGPET
ERKRGELRVE KERLDQAMEI IVNLENKEQM ATATAANSQV TTQMMSQGGH GGQRPELSIR
TNANGGVATP VSERAPTPIG TYEA
//
