ID Q7S3R4_NEUCR Unreviewed; 434 AA.
AC Q7S3R4;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 24-JAN-2024, entry version 123.
DE SubName: Full=Penicillopepsin {ECO:0000313|EMBL:EAA30165.1};
GN ORFNames=NCU04953 {ECO:0000313|EMBL:EAA30165.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA30165.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA30165.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; CM002239; EAA30165.1; -; Genomic_DNA.
DR RefSeq; XP_959401.1; XM_954308.2.
DR AlphaFoldDB; Q7S3R4; -.
DR MEROPS; A01.079; -.
DR PaxDb; 5141-EFNCRP00000004868; -.
DR EnsemblFungi; EAA30165; EAA30165; NCU04953.
DR GeneID; 3875539; -.
DR KEGG; ncr:NCU04953; -.
DR VEuPathDB; FungiDB:NCU04953; -.
DR HOGENOM; CLU_013253_0_0_1; -.
DR InParanoid; Q7S3R4; -.
DR OMA; SDTWVFN; -.
DR OrthoDB; 2900143at2759; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd06097; Aspergillopepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR034163; Aspergillopepsin-like_cat_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966:SF23; ASPARTIC ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15950)-RELATED; 1.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU000454}; Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..434
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004292560"
FT DOMAIN 124..431
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 80..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 140
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 325
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
SQ SEQUENCE 434 AA; 46509 MW; CAB7A5E12C1BC67A CRC64;
MPVLFKLFIF SVLLSLVVAV PLTKRSFKVE RVRNPNFKGR NGPRELLKAY RKYRMPVPQP
LLDAMNNQMN GTTPTITSIT QADTDTSESE SLRLDATGGS STAPAAGTAT GAVTATPEQD
DVEYLAPVTI GGQTINLDFD SGSSDLWVFN TQLSPQLTAG HQVYNPAASK TFKLLPGHTF
EISYGDGSAA AGNVGTDVVE IGGVSVQNQA VELATKVTQT FIQDTQNNGL LGLAFSKLNT
VQPQQQKTFF DNVLPSLAEP VFTADLRHNA VGAYEFGRID NTKFTGQLAW IPVNTGMGFW
QFTTSAFSVG NGQAVKVKPA QAIADTGTTL MLVSQSVANA YYSQVQGAKN DPNAGGITFP
CNTNLPDLFV DVGGRYMARI KGDDIRFSQI DATTCFGGVQ PTTSALEIWG DIFFKSQFVV
FNGGNNTLGM AQHV
//