ID Q7S683_NEUCR Unreviewed; 624 AA.
AC Q7S683;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 3.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Cytochrome P450 2C30 {ECO:0000313|EMBL:EAA31017.3};
GN ORFNames=NCU07092 {ECO:0000313|EMBL:EAA31017.3};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA31017.3, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA31017.3, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|RuleBase:RU000461}.
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DR EMBL; CM002241; EAA31017.3; -; Genomic_DNA.
DR RefSeq; XP_960253.3; XM_955160.3.
DR AlphaFoldDB; Q7S683; -.
DR STRING; 367110.Q7S683; -.
DR PaxDb; 5141-EFNCRP00000006970; -.
DR EnsemblFungi; EAA31017; EAA31017; NCU07092.
DR GeneID; 3876416; -.
DR KEGG; ncr:NCU07092; -.
DR VEuPathDB; FungiDB:NCU07092; -.
DR HOGENOM; CLU_001570_2_1_1; -.
DR InParanoid; Q7S683; -.
DR OrthoDB; 2900138at2759; -.
DR Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR46300:SF6; CYTOCHROME P450 2C30; 1.
DR PANTHER; PTHR46300; P450, PUTATIVE (EUROFUNG)-RELATED-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 290..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 624 AA; 71813 MW; D4189307C57281BC CRC64;
MQLLTLVIVG LFMLIVAVVH FIKAFREVND PNGIPGPTQI PYLGRVHDLP IQFMWLKFKE
WADKYGQQGF YRTMMLGAEF IVVTDEKVAE DLLVKRAKYN SDRPVIQSLF DSKSTHGSME
YLPLMGHNTY WARQRKLSHS YLTEATKAHY YGVMYFEVQR WMARLLENPE DFQHSIEDMS
SKVMCQLTWD DPSLSEYCTK SAWGLLTQMS PAGPITNVLT PLWHLPTLIN PWKRAERKRH
DEQQAWWMER LLTCREKLAR GELRPCWTRQ FLEKTSQKTS ISGDYEASCV IGMLALVGIF
TVVGPMSYWL VSMVHNPKWQ EAVQREVDEV CGNRMPRLED APRLPILRAC IKETMRWKPN
VPTGVAHETE ADDHYQGYFI PKGTRILPFD WSFLRNPVKY PDPENFRPER WLEPGWPTYK
EPLTQYPTIK GLTSFGWGQR QCLGMSLTQD ELIVGCGALA WLFNLRHKRD PITGRELPVP
LDRSNSLLII KPDPFQMEFE PRSKERKKEA LRVWKESEAK DRARRERWLR NVKEGKPNVI
KEPKVLQPTV KIPSPSPAAA VPAALVDGGE VRDELSKTVQ VVKEKSGGVN GHGDSLAEKA
VMDVKKKADI SITIARLDST ACVY
//
