ID Q7SCW4_NEUCR Unreviewed; 679 AA.
AC Q7SCW4;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Pumilio domain-containing protein {ECO:0000313|EMBL:EAA34590.1};
GN ORFNames=NCU09380 {ECO:0000313|EMBL:EAA34590.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA34590.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA34590.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: RNA-binding nucleolar protein required for pre-rRNA
CC processing. Involved in production of 18S rRNA and assembly of small
CC ribosomal subunit. {ECO:0000256|ARBA:ARBA00024893}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM002236; EAA34590.1; -; Genomic_DNA.
DR RefSeq; XP_963826.1; XM_958733.2.
DR AlphaFoldDB; Q7SCW4; -.
DR SMR; Q7SCW4; -.
DR STRING; 367110.Q7SCW4; -.
DR PaxDb; 5141-EFNCRP00000009471; -.
DR EnsemblFungi; EAA34590; EAA34590; NCU09380.
DR GeneID; 3879975; -.
DR KEGG; ncr:NCU09380; -.
DR VEuPathDB; FungiDB:NCU09380; -.
DR HOGENOM; CLU_013994_1_0_1; -.
DR InParanoid; Q7SCW4; -.
DR OMA; YGPEFSI; -.
DR OrthoDB; 5479527at2759; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0006417; P:regulation of translation; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012959; CPL_dom.
DR InterPro; IPR033133; PUM-HD.
DR InterPro; IPR040059; PUM3.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR PANTHER; PTHR13389:SF0; PUMILIO HOMOLOG 3; 1.
DR PANTHER; PTHR13389; UNCHARACTERIZED; 1.
DR Pfam; PF08144; CPL; 1.
DR SMART; SM00025; Pumilio; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50303; PUM_HD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 72..444
FT /note="PUM-HD"
FT /evidence="ECO:0000259|PROSITE:PS50303"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 679 AA; 75033 MW; 195CB5B3CED42604 CRC64;
MATKSSSAAA AGGKRKAFGK HNEDGRTKAV KTTSGKKHIK AEAEDNESSD ESSDAEFHTG
ETTTSTPNES GNGSNETKSG TSSREAHAKQ KQLAQERKNA KPLADEVHRT KKLWEKLRRK
SHVPKEERQQ LVEELFTIIT GRIKDFVLKH DAVRAVQTAV KYATPVQRRQ IAKELQGTYA
QLAESRYAKF LIGKLLVQND KEIRDIIVPE FYGKVRKLIN HAEGSWILDD VYRGVATKEQ
KANLLREWYG PEFALFRQPK GTEVTGDLSK ILADEPSKRT TAMKYLFDMA NGLIQKKMTG
FTMLHDALLQ YFLNLNPESE EFKEFFETIK EDETGDLLKN MAFTKSGARL VCLLLAHGTA
KDRKQLLKAY KDTYQLMSGD NHAHAIILAA YDLLDDTVLT SKTIFSEILG KNEEKDAEHV
IFLANDLNAR TTVLYLFEGM SKALFPASHA TDLEILKEIH EIRTKTSKKD AEVRRKELVT
AMSPQLLAAI ASSPADLVAT SFGCQFVTDV LLSATGDKKA ALEAIASTAG GDPNAEAPKD
AYQALPPHIS TTIHGGRMFK TLIAGGRFDK ATGSIQKVDP PLNFADLLYP VIKDHIVQWA
TGPSSWTVLA MLEASDFSSK KELLKTLKSN KKALIKAATE APASKKEEME EKPKAKKGKN
ASAPKGNQGS KLLLEKLDA
//
