ID Q7SGC4_NEUCR Unreviewed; 984 AA.
AC Q7SGC4;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=Nitrogen permease regulator 3 {ECO:0000256|ARBA:ARBA00017880, ECO:0000256|RuleBase:RU368069};
DE AltName: Full=Required for meiotic nuclear division protein 11 {ECO:0000256|ARBA:ARBA00030028, ECO:0000256|RuleBase:RU368069};
GN ORFNames=NCU02725 {ECO:0000313|EMBL:EAA35874.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA35874.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA35874.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC amino acid starvation. Required for meiotic nuclear division.
CC {ECO:0000256|ARBA:ARBA00025376, ECO:0000256|RuleBase:RU368069}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000256|RuleBase:RU368069};
CC Peripheral membrane protein {ECO:0000256|RuleBase:RU368069}.
CC -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC ECO:0000256|RuleBase:RU368069}.
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DR EMBL; CM002236; EAA35874.1; -; Genomic_DNA.
DR RefSeq; XP_965110.1; XM_960017.2.
DR AlphaFoldDB; Q7SGC4; -.
DR STRING; 367110.Q7SGC4; -.
DR PaxDb; 5141-EFNCRP00000002186; -.
DR EnsemblFungi; EAA35874; EAA35874; NCU02725.
DR GeneID; 3881250; -.
DR KEGG; ncr:NCU02725; -.
DR VEuPathDB; FungiDB:NCU02725; -.
DR HOGENOM; CLU_014314_2_0_1; -.
DR InParanoid; Q7SGC4; -.
DR OrthoDB; 1381214at2759; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:1990130; C:GATOR1 complex; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-UniRule.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR GO; GO:0038202; P:TORC1 signaling; IBA:GO_Central.
DR InterPro; IPR005365; Npr3.
DR PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR Pfam; PF03666; NPR3; 1.
PE 3: Inferred from homology;
KW Meiosis {ECO:0000256|RuleBase:RU368069};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Signal {ECO:0000256|RuleBase:RU368069}.
FT REGION 153..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 107167 MW; 69E87B5BCE9027E4 CRC64;
MAYPVLPSPD NFLAVALVIN RSRDGPRFVF HYPPHVLPPQ ATAAARDGDD LDDLDEEDEA
LLHRVTHAVG LDASSSSPLK ESELSQWNHD DHLITESGTQ IVPWEHVAGF PTKDLENILT
PARAYHKRLF QVSLDSLYCV SYPIYVPENG VWRKKSKKQQ KHRDHDDTAP ADTDGPARTS
DKGPSDVDQL AAKPAEEAED KKSSMTMFNL VFILNPRRHE VADLVDILYT HIIKKVNKAY
KYCQQRGDFI WKESKKILAL KDKGREDKRK MSQLWEEILS NSSLAASMQD IYDAISRNRI
AAIQLETIEG VVTHSVQIPV PFHVPDLPQD GQAEEQLGLW LTTANSLQAD ENVEEPEYLD
KTFALLLMAE EKKVINELLG PESDPTTQAM IEFVRRCKPN LSFHQVQQQA SSILSPAQVR
RFAEHFIFWR RAIAIPPLHG RDMYIVSPNC DLRRLPQAAA QWARQFPLSP PLPNFLAELG
VAPRPYKLHC PSKAHRPLYM AMLAWLMRGG WVTQLCTFAY VVVWPEIIYE VEYELEAEEI
AHEKAKAQNR GREDQDHKHD DMLSPTTAAD NSGDIGGPGN NVLAAALSEG PLAGFAGSGF
LSLAAESTSA SDLDSSAATL RDLSNSQSPT LSRAQPASTP ISEFLPTLTS PMSTTSLSTL
ILGTSDYMTN SHKDNYNNNG SSSPTASYAS ANTLNMLNPP RPTLQLTRTI SEDTNASAGT
SSTHHQPTPA EQAAEKARLE RIADKAAREL AERAMAHARK AVPQATRHPS VNHAKHLLGM
SPHIILDAKK ATGKESLYLS AIERRLRGRG GEVATTTAAT VAAAGASEAG TGSDAAATDG
AGVEASGTGS EDAAAAGAGN GNNNNNNNKN SSSANASSNT ATSNDATNIA SSSATGTHTT
GASAKTAGGT GTSGGGRTVS GSASAQRGTK DWDERVANTW PQFWKYFNGR SALERIALQE
DMKRKEAWSL LTAMSEYLLC TRHW
//
