ID   Q7SS23_9HIV1            Unreviewed;       190 AA.
AC   Q7SS23;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:AAP72824.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:AAP72824.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAP72824.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAP72824.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12700457; DOI=10.1097/00002030-200305020-00016;
RA   Brindeiro R.M., Diaz R.S., Sabino E.C., Morgado M.G., Pires I.L.,
RA   Brigido L., Dantas M.C., Barreira D., Teixeira P.R., Soares M.A.,
RA   Tanuri A.;
RT   "Brazilian Network for HIV Drug Resistance Surveillance (HIV-BResNet): a
RT   survey of chronically infected individuals.";
RL   AIDS 17:1063-1069(2003).
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DR   EMBL; AY213421; AAP72824.1; -; Genomic_RNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF5; RIBONUCLEASE H; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW   ECO:0000313|EMBL:AAP72824.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          9..190
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAP72824.1"
FT   NON_TER         190
FT                   /evidence="ECO:0000313|EMBL:AAP72824.1"
SQ   SEQUENCE   190 AA;  22091 MW;  FC1BBCE94BDB625B CRC64;
     EICTEMEKEG KISKIGPENP YNTPVFAIKK KDGTKWRKLV DFRELNKRTQ DFWEVQLGIP
     HPAGLKKKKS VTVLDVGDAY FSVPLDEDFR KYTAFTIPST NNETPGIRYQ YNVLPQGWKG
     SPAIFQSSMT KILEPFRKQN PDIVIYQYMD DLYVGSDLEI GQHRAKIEEL REHLLKWGFT
     TPDKKHQKEP
//