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Database: UniProt
Entry: Q7SZM9
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Original site: Q7SZM9 
ID   TB1RA_XENLA             Reviewed;         519 AA.
AC   Q7SZM9;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   29-OCT-2014, entry version 72.
DE   RecName: Full=F-box-like/WD repeat-containing protein TBL1XR1-A;
DE   AltName: Full=Nuclear receptor corepressor/HDAC3 complex subunit TBLR1-A;
DE   AltName: Full=TBL1-related protein 1-A;
DE            Short=xTBLR1;
DE   AltName: Full=Transducin beta-like 1X-related protein 1-A;
GN   Name=tbl1xr1-a; Synonyms=tblr1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH NCOR1; RARA AND RXRA.
RX   PubMed=12794076; DOI=10.1074/jbc.M303309200;
RA   Tomita A., Buchholz D.R., Obata K., Shi Y.-B.;
RT   "Fusion protein of retinoic acid receptor-alpha with promyelocytic
RT   leukemia protein or promyelocytic leukemia zinc finger protein
RT   recruits N-CoR-TBLR1 corepressor complex to repress transcription in
RT   vivo.";
RL   J. Biol. Chem. 278:30788-30795(2003).
RN   [2]
RP   INTERACTION WITH NCOR1; RXRA AND THRB, AND DEVELOPMENTAL STAGE.
RX   PubMed=15060155; DOI=10.1128/MCB.24.8.3337-3346.2004;
RA   Tomita A., Buchholz D.R., Shi Y.-B.;
RT   "Recruitment of N-CoR/SMRT-TBLR1 corepressor complex by unliganded
RT   thyroid hormone receptor for gene repression during frog
RT   development.";
RL   Mol. Cell. Biol. 24:3337-3346(2004).
CC   -!- FUNCTION: F-box-like protein which acts as an integral component
CC       of the N-CoR transcriptional corepressor complex. Probably
CC       regulates transcription activation mediated by nuclear receptors.
CC       May mediate the recruitment of the 19S proteasome complex, leading
CC       to the subsequent proteasomal degradation of the N-CoR complex,
CC       thereby allowing cofactor exchange and transcription activation
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with heterodimers of rxra and thrb, and this
CC       interaction is abrogated by thyroid hormone binding to thrb.
CC       Interacts with ncor1. {ECO:0000269|PubMed:12794076,
CC       ECO:0000269|PubMed:15060155}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the developing intestine both
CC       prior to and during remodeling (stages NF54 to NF66).
CC       {ECO:0000269|PubMed:15060155}.
CC   -!- DOMAIN: The F-box-like domain is related to the F-box domain, and
CC       also functions to recruit ubiquitin E3 ligase complexes.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat EBI family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 F-box-like domain. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 LisH domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00126}.
CC   -!- SIMILARITY: Contains 8 WD repeats. {ECO:0000255|PROSITE-
CC       ProRule:PRU00221}.
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DR   EMBL; AY225088; AAP20646.1; -; mRNA.
DR   RefSeq; NP_001082621.1; NM_001089152.1.
DR   UniGene; Xl.83170; -.
DR   ProteinModelPortal; Q7SZM9; -.
DR   BioGrid; 99938; 4.
DR   IntAct; Q7SZM9; 1.
DR   GeneID; 398608; -.
DR   KEGG; xla:398608; -.
DR   CTD; 398608; -.
DR   Xenbase; XB-GENE-6255786; tbl1xr1.
DR   HOVERGEN; HBG050240; -.
DR   KO; K04508; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR006594; LisH_dimerisation.
DR   InterPro; IPR013720; LisH_dimerisation_subgr.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   Pfam; PF08513; LisH; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00667; LisH; 1.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS50896; LISH; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Activator; Chromatin regulator; Nucleus; Repeat; Repressor;
KW   Transcription; Transcription regulation; Ubl conjugation pathway;
KW   WD repeat.
FT   CHAIN         1    519       F-box-like/WD repeat-containing protein
FT                                TBL1XR1-A.
FT                                /FTId=PRO_0000051268.
FT   DOMAIN        4     36       LisH. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00126}.
FT   DOMAIN       41     86       F-box-like.
FT   REPEAT      172    211       WD 1.
FT   REPEAT      228    267       WD 2.
FT   REPEAT      269    308       WD 3.
FT   REPEAT      311    349       WD 4.
FT   REPEAT      352    391       WD 5.
FT   REPEAT      394    442       WD 6.
FT   REPEAT      445    484       WD 7.
FT   REPEAT      486    519       WD 8.
FT   COMPBIAS    109    120       Poly-Ala.
SQ   SEQUENCE   519 AA;  56043 MW;  5E998EDC8C892296 CRC64;
     MSISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALAPPAALI SIIQKGLQYV
     EAEVSINEDG TLFDGRPIES LSLIDAVMPD VVQTRQQAYR DKLAQQQTAA AAAAAAAAAA
     TPNNQQPPAK NGENTANGEE NGGHALANNH TDMMEVDGDV EIPSSKAVVL RGHESEVFIC
     AWNPVSDLLA SGSGDSTARI WNLSENSTSG STQLVLRHCI REGGQDVPSN KDVTSLDWNS
     EGTLLATGSY DGFARIWTKD GNLASTLGQH KGPIFALKWN KKGNFILSAG VDKTTIIWDA
     HTGEAKQQFP FHSAPALDVD WQSNNTFASC STDMCIHVCK LGQDRPIKTF QGHTNEVNAI
     KWDPTGNLLA SCSDDMTLKI WSMKHDTCVH DLQAHNKEIY TIKWSPTGPG TNNPNANLML
     ASASFDSTVR LWDVDRGICI HTLTKHQEPV YSVAFSPDGR YLASGSFDKC VHIWNTQTGA
     LVHSYRGTGG IFEVCWNAAG DKVGASASDG SVCVLDLRK
//
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