ID Q7T040_ORYCU Unreviewed; 804 AA.
AC Q7T040;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 22-FEB-2023, entry version 86.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN Name=OcGCS-alpha2 {ECO:0000313|EMBL:BAC80221.1};
OS Oryzias curvinotus (Hynann ricefish) (Aplocheilus curvinotus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=104658 {ECO:0000313|EMBL:BAC80221.1};
RN [1] {ECO:0000313|EMBL:BAC80221.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:BAC80221.1};
RX PubMed=15465675; DOI=10.1016/j.cbpc.2004.08.001;
RA Shiga T., Suzuki N.;
RT "Expression of guanylyl cyclase genes in medaka hybrids (Oryzias curvinotus
RT x Oryzias latipes).";
RL Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 139:281-286(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; AB115704; BAC80221.1; -; mRNA.
DR AlphaFoldDB; Q7T040; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655:SF7; GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2; 1.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134}.
FT DOMAIN 589..716
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 530..561
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 804 AA; 89053 MW; 239A58CE86F93F24 CRC64;
MSSSSRKISS ESFSSSVGSD CGLESPGGDG GGGGPELAEE NRGCPFSSLP FSQRALLWNG
RSSAERSACA ASEEQQQQQG PFIPHKRVTR RRRVNLDSLG ESLKRLTSPT TQTVQEALQR
TLQFYRKQEI RCQEVKSAER RRERTEEKCP FLESSGSEED VLQILQYMAT ILGVPFCELR
EHFGEEFFGL CFEENERVLR AVGGNLQDFF NGFDAILEHI RTSTGRRASS ESPSFQCKDP
REEEKGRRKL DKVGNHGKVL LLHCFNPAPV VGLVMPGLIR AVARRIFHSE VEVEEVPPLT
PLLPNEDTAH TGFDSTTPTP TASPTASPSS SPSPPSLFPT SIPTVCLSFQ IQEVCPSSLL
SSPSSSSDSI KRPPLSLSTN PSDLRIGLAT FCRAFPFHLV LGPHMELLQL GEGLRRQARI
EPHRSFSFRD CFEIVSPKME PSFQGILLRL ASPFTIRTRP DSTQAGTKEK VMELKGQMIH
VPESCSLMFL GSPRVDKLEE LMGRGLHLSD IPIHDATRDV ILVGEQAKAQ DGLKKRMDKL
KATLERTHQA LEEEKRRTVD LLYSIFPGDV AQKLWQGQPV PARKFDDVTM LFSDIVGFTA
VCAHCTPMQV ISMLNELYTR FDYQCGILDV YKIETIGDAY CVAGGLHKKV ESHAKPIAHM
ALKMMELSEE VLTPDGKPIK LRIGIHTGSV LAGVVGVKMP RYCLFGNNVT LASKFESGSH
PRCINVSPTT YQLLKDDRSF SFVPRSRMDL PENFPKEIPG ACYFLEAGTS HSHASLTSSR
SAPPASMRKV SYSIGTMFLR ETSL
//
