ID MTPN_XENLA Reviewed; 118 AA.
AC Q7T0Q1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Myotrophin;
GN Name=mtpn;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates NF-kappa-B transcription factor activity. Promotes
CC growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes
CC cardiac muscle hypertrophy. Plays a role in the regulation of the
CC growth of actin filaments. Inhibits the activity of the F-actin-capping
CC protein complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Cytoplasm, perinuclear region {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the myotrophin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC056092; AAH56092.1; -; mRNA.
DR RefSeq; NP_001079881.1; NM_001086412.1.
DR AlphaFoldDB; Q7T0Q1; -.
DR SMR; Q7T0Q1; -.
DR DNASU; 379571; -.
DR GeneID; 379571; -.
DR KEGG; xla:379571; -.
DR AGR; Xenbase:XB-GENE-1014019; -.
DR CTD; 379571; -.
DR Xenbase; XB-GENE-1014019; mtpn.S.
DR OrthoDB; 5475373at2759; -.
DR Proteomes; UP000186698; Chromosome 3S.
DR Bgee; 379571; Expressed in intestine and 19 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24157:SF0; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 34A-RELATED; 1.
DR PANTHER; PTHR24157; ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 3: Inferred from homology;
KW ANK repeat; Cytoplasm; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..118
FT /note="Myotrophin"
FT /id="PRO_0000330662"
FT REPEAT 1..30
FT /note="ANK 1"
FT REPEAT 34..65
FT /note="ANK 2"
FT REPEAT 67..98
FT /note="ANK 3"
SQ SEQUENCE 118 AA; 12744 MW; BE4A7017614869CB CRC64;
MGDKEFMWAL KNGDLDAVKE FVAGGVDVNR TLEGGRKPLH YAADCGQDEI VEFLLAKGAN
INAADKHGIT PLLSACYEGH RKCVELFVSK GADKNVKGPD GLNAFESTDN QAIKDLLH
//
