ID Q7T1K2_DANRE Unreviewed; 470 AA.
AC Q7T1K2; A0A2R8RZ02; F6PDW4;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 177.
DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
GN Name=traf4a {ECO:0000313|EMBL:AAH65969.1,
GN ECO:0000313|Ensembl:ENSDARP00000013849,
GN ECO:0000313|RefSeq:NP_991325.1, ECO:0000313|ZFIN:ZDB-GENE-040308-1};
GN Synonyms=traf4 {ECO:0000313|EMBL:CAD89005.1}, zgc:77418
GN {ECO:0000313|RefSeq:NP_991325.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH65969.1};
RN [1] {ECO:0000313|EMBL:AAH65969.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH65969.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAD89005.1, ECO:0000313|RefSeq:NP_991325.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15749085; DOI=10.1016/j.modgep.2004.10.011;
RA Kedinger V., Alpy F., Tomasetto C., Thisse C., Thisse B., Rio M.C.;
RT "Spatial and temporal distribution of the traf4 genes during zebrafish
RT development.";
RL Gene Expr. Patterns 5:545-552(2005).
RN [3] {ECO:0000313|RefSeq:NP_991325.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18039395;
RA Stein C., Caccamo M., Laird G., Leptin M.;
RT "Conservation and divergence of gene families encoding components of innate
RT immune response systems in zebrafish.";
RL Genome Biol. 8:R251-R251(2007).
RN [4] {ECO:0000313|RefSeq:NP_991325.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17868904; DOI=10.1016/j.vetimm.2007.08.001;
RA Xu Z.Y., Sun B.J., Chang M.X., Nie P.;
RT "Characterization and expression analysis of TNFR-associated factor 1
RT (TRAF1) in grass carp Ctenopharyngodon idella.";
RL Vet. Immunol. Immunopathol. 121:44-57(2008).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000013849}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000013849};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [6] {ECO:0000313|Ensembl:ENSDARP00000013849, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000013849};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [7] {ECO:0000313|RefSeq:NP_991325.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24349563;
RA Liu C., Xu H., Lam S.H., Gong Z.;
RT "Selection of reliable biomarkers from PCR array analyses using relative
RT distance computational model: methodology and proof-of-concept study.";
RL PLoS ONE 8:e83954-e83954(2013).
RN [8] {ECO:0000313|RefSeq:NP_991325.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [9] {ECO:0000313|RefSeq:NP_991325.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27581768;
RA Mandriani B., Castellana S., Rinaldi C., Manzoni M., Venuto S.,
RA Rodriguez-Aznar E., Galceran J., Nieto M.A., Borsani G., Monti E.,
RA Mazza T., Merla G., Micale L.;
RT "Identification of p53-target genes in Danio rerio.";
RL Sci. Rep. 6:32474-32474(2016).
RN [10] {ECO:0000313|RefSeq:NP_991325.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27913641;
RA Miao L., Yuan Y., Cheng F., Fang J., Zhou F., Ma W., Jiang Y., Huang X.,
RA Wang Y., Shan L., Chen D., Zhang J.;
RT "Translation repression by maternal RNA binding protein Zar1 is essential
RT for early oogenesis in zebrafish.";
RL Development 144:128-138(2017).
RN [11] {ECO:0000313|RefSeq:NP_991325.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [12] {ECO:0000313|Ensembl:ENSDARP00000156311}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000156311};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [13] {ECO:0000313|RefSeq:NP_991325.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR015614}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000256|PIRNR:PIRNR015614}.
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DR EMBL; CR392353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR848661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR855391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC065969; AAH65969.1; -; mRNA.
DR EMBL; AJ556548; CAD89005.1; -; mRNA.
DR RefSeq; NP_991325.1; NM_205762.1.
DR STRING; 7955.ENSDARP00000013849; -.
DR PaxDb; 7955-ENSDARP00000013849; -.
DR Ensembl; ENSDART00000016024.9; ENSDARP00000013849.8; ENSDARG00000003963.9.
DR Ensembl; ENSDART00000184122.1; ENSDARP00000156311.1; ENSDARG00000109586.1.
DR GeneID; 404045; -.
DR KEGG; dre:404045; -.
DR AGR; ZFIN:ZDB-GENE-040308-1; -.
DR CTD; 404045; -.
DR ZFIN; ZDB-GENE-040308-1; traf4a.
DR eggNOG; KOG0297; Eukaryota.
DR HOGENOM; CLU_021061_6_0_1; -.
DR OMA; EWPFAYK; -.
DR OrthoDB; 2913784at2759; -.
DR TreeFam; TF321154; -.
DR Proteomes; UP000000437; Alternate scaffold 15.
DR Proteomes; UP000000437; Chromosome 15.
DR Bgee; ENSDARG00000003963; Expressed in brain and 22 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045198; P:establishment of epithelial cell apical/basal polarity; IMP:ZFIN.
DR GO; GO:0002072; P:optic cup morphogenesis involved in camera-type eye development; IMP:ZFIN.
DR GO; GO:0003405; P:optic vesicle elongation; IMP:ZFIN.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd03781; MATH_TRAF4; 1.
DR CDD; cd16641; mRING-HC-C3HC3D_TRAF4; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR037307; TRAF4_MATH.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF144; TNF RECEPTOR-ASSOCIATED FACTOR 4; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF02176; zf-TRAF; 2.
DR PIRSF; PIRSF015614; TRAF; 1.
DR SMART; SM00061; MATH; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 4.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 3.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR015614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR015614};
KW Receptor {ECO:0000313|EMBL:AAH65969.1, ECO:0000313|RefSeq:NP_991325.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015614};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT DOMAIN 18..58
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 101..154
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 156..208
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 210..266
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 307..462
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT ZN_FING 101..154
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 156..208
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 210..266
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
SQ SEQUENCE 470 AA; 54427 MW; B4CEA2AE913363D3 CRC64;
MPGFDYKFLE KPKRRFQCPL CSKAMREPVQ VSTCGHRFCD TCLQEFLSEG VFKCPEDQLP
LDYAKIYPDP ELEQQILALP IRCIHSEEGC RWTGQMKQLQ SHFSTCAFNV IPCPNRCSVK
LTRRDLPEHL QHDCPKRKVK CEFCGSEFTG EAYENHQGIC PQESVYCENK CGARMMRRLL
SQHTMTECPK RTQPCKYCGK EFVYDTIQNH QYHCPRFPVQ CPNQCGTPNI AREDLANHVK
ESCGSALVLC PFKEAGCKHR CPKMAIGRHL EESTKSHLTM MCSLVGRQRQ EILELRREME
ELSVSHDGVL IWKLTDYSRK LQEAKLRNNH EFFSPPFYTH RYGYKLQVSA FLNGNGSGEG
SHLSIYIRVL PGEYDNLLEW PFSYKVTFSI LDQSDPSLSK PQHITETFNP DPNWKNFQKP
CSSRNSLDES TLGFGYPKFI SHEEIKKRNY IRDNSIFLKA SIEIPQKIMA
//
