ID Q7T3F6_DANRE Unreviewed; 293 AA.
AC Q7T3F6; A0A8M1PCT4;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 158.
DE SubName: Full=Pleckstrin homology domain-containing family F member 1 {ECO:0000313|RefSeq:NP_956634.1};
DE SubName: Full=Pleckstrin homology domain-containing, family F (with FYVE domain) member 1 {ECO:0000313|EMBL:AAH53138.1, ECO:0000313|Ensembl:ENSDARP00000140389};
GN Name=plekhf1 {ECO:0000313|EMBL:AAH53138.1,
GN ECO:0000313|Ensembl:ENSDARP00000140389,
GN ECO:0000313|RefSeq:NP_956634.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-1289};
GN Synonyms=zgc:63897 {ECO:0000313|RefSeq:NP_956634.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH53138.1};
RN [1] {ECO:0000313|EMBL:AAH53138.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH53138.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_956634.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20851470;
RA Stockhammer O.W., Rauwerda H., Wittink F.R., Breit T.M., Meijer A.H.,
RA Spaink H.P.;
RT "Transcriptome analysis of Traf6 function in the innate immune response of
RT zebrafish embryos.";
RL Mol. Immunol. 48:179-190(2010).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000140389, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000140389};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_956634.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000140389}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000140389};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [6] {ECO:0000313|RefSeq:NP_956634.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28329862;
RA Schuttler A., Reiche K., Altenburger R., Busch W.;
RT "The Transcriptome of the Zebrafish Embryo After Chemical Exposure: A Meta-
RT Analysis.";
RL Toxicol. Sci. 157:291-304(2017).
RN [7] {ECO:0000313|RefSeq:NP_956634.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR352229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR385058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC053138; AAH53138.1; -; mRNA.
DR RefSeq; NP_956634.1; NM_200340.1.
DR STRING; 7955.ENSDARP00000140389; -.
DR PaxDb; 7955-ENSDARP00000039223; -.
DR Ensembl; ENSDART00000170253.2; ENSDARP00000140389.1; ENSDARG00000102435.2.
DR Ensembl; ENSDART00000185359.1; ENSDARP00000154816.1; ENSDARG00000110694.1.
DR GeneID; 393311; -.
DR KEGG; dre:393311; -.
DR AGR; ZFIN:ZDB-GENE-040426-1289; -.
DR CTD; 79156; -.
DR ZFIN; ZDB-GENE-040426-1289; plekhf1.
DR eggNOG; KOG1729; Eukaryota.
DR HOGENOM; CLU_064864_0_0_1; -.
DR OMA; VIMENQW; -.
DR OrthoDB; 5385125at2759; -.
DR TreeFam; TF315235; -.
DR Proteomes; UP000000437; Alternate scaffold 7.
DR Proteomes; UP000000437; Chromosome 7.
DR Bgee; ENSDARG00000102435; Expressed in pharyngeal gill and 17 other cell types or tissues.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:0008333; P:endosome to lysosome transport; IBA:GO_Central.
DR CDD; cd01218; PH_Phafin2-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037871; PH_Phafin.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46280:SF2; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1; 1.
DR PANTHER; PTHR46280; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 35..131
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 155..214
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 222..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 293 AA; 33769 MW; F2A87D4CA5F3FE5F CRC64;
MAEHLAFTIQ NRERIQAVES SFGRTGKMLQ KPGRFLVGEG CLQKLCRRGP QPRVFYLFND
ILVYGSIMLH GRWNNKQNII PLEEVQQEDL EDGMAMANQW LIRTPRKSFY VSAESPEEKI
AWMGHIEQYR TLHVKNKGLP AKKSGDDFAT PWIPDVASAI CMRCSKRFTV ANRRHHCRRC
GYIVCQACSK GRAVLPHISN RPVRVCRNCK NDMTDGMRQV QGKMRAKGNH WKKNSVEDTP
TMPEFENSSD EENENADECH QVPTKWFQSQ EEDSFSAYCY IKPEHRNPPV GGH
//
