ID Q7T3T6_DANRE Unreviewed; 1350 AA.
AC Q7T3T6;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE SubName: Full=Tenascin-R {ECO:0000313|EMBL:AAP37046.1, ECO:0000313|RefSeq:NP_919364.1};
GN Name=tnr {ECO:0000313|RefSeq:NP_919364.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030804-1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAP37046.1};
RN [1] {ECO:0000313|EMBL:AAP37046.1, ECO:0000313|RefSeq:NP_919364.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12867507;
RA Becker C.G., Schweitzer J., Feldner J., Becker T., Schachner M.;
RT "Tenascin-R as a repellent guidance molecule for developing optic axons in
RT zebrafish.";
RL J. Neurosci. 23:6232-6237(2003).
RN [2] {ECO:0000313|RefSeq:NP_919364.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15234343;
RA Becker C.G., Schweitzer J., Feldner J., Schachner M., Becker T.;
RT "Tenascin-R as a repellent guidance molecule for newly growing and
RT regenerating optic axons in adult zebrafish.";
RL Mol. Cell. Neurosci. 26:376-389(2004).
RN [3] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_919364.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25981450; DOI=10.1016/j.gep.2015.05.002;
RA Giousoh A., Vaz R., Bryson-Richardson R.J., Whisstock J.C., Verkade H.,
RA Bird P.I.;
RT "Bone morphogenetic protein/retinoic acid inducible neural-specific protein
RT (brinp) expression during Danio rerio development.";
RL Gene Expr. Patterns 18:37-43(2015).
RN [5] {ECO:0000313|RefSeq:NP_919364.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [6] {ECO:0000313|RefSeq:NP_919364.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [7] {ECO:0000313|RefSeq:NP_919364.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [8] {ECO:0000313|RefSeq:NP_919364.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28392072;
RA Thomas-Jinu S., Gordon P.M., Fielding T., Taylor R., Smith B.N.,
RA Snowden V., Blanc E., Vance C., Topp S., Wong C.H., Bielen H.,
RA Williams K.L., McCann E.P., Nicholson G.A., Pan-Vazquez A., Fox A.H.,
RA Bond C.S., Talbot W.S., Blair I.P., Shaw C.E., Houart C.;
RT "Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts
RT Required for Normal Motor Development.";
RL Neuron 94:322-336(2017).
RN [9] {ECO:0000313|RefSeq:NP_919364.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the tenascin family.
CC {ECO:0000256|ARBA:ARBA00008673}.
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DR EMBL; AY286489; AAP37046.1; -; mRNA.
DR RefSeq; NP_919364.1; NM_194383.1.
DR GeneID; 369191; -.
DR KEGG; dre:369191; -.
DR AGR; ZFIN:ZDB-GENE-030804-1; -.
DR CTD; 7143; -.
DR ZFIN; ZDB-GENE-030804-1; tnr.
DR OrthoDB; 5489847at2759; -.
DR PhylomeDB; Q7T3T6; -.
DR Proteomes; UP000000437; Chromosome 2.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IDA:ZFIN.
DR CDD; cd00063; FN3; 9.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR041161; EGF_Tenascin.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR PANTHER; PTHR46708:SF6; TENASCIN-R; 1.
DR Pfam; PF18720; EGF_Tenascin; 3.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR Pfam; PF00041; fn3; 9.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00186; FBG; 1.
DR SMART; SM00060; FN3; 9.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50853; FN3; 7.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q7T3T6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_919364.1}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1350
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_919364.1"
FT /id="PRO_5035035645"
FT DOMAIN 323..414
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 501..592
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 593..682
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 683..772
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 860..949
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 950..1035
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1036..1130
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1122..1337
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
SQ SEQUENCE 1350 AA; 147958 MW; 0A69EDCC79C8CA24 CRC64;
MWGCTMAIQG SVVSLALLFF GIQAVPSPTS KLVRTTRVRR QVPEGGDPAD NQMQPMVFNH
VYNINVPVES LCSVDLDAVT GPETNKTASG SDKMPTEYTE ETVDSDSQVT FTHRINIPKQ
ACACPSATTI EQLASRIEML EREVSLLRTQ CSSSCCGESS VMGRLDFVPQ CGHGTFSMEV
CGCVCEEGWI GKNCTEPRCP DDCSGQGICI EGDCVCDRNF GGENCSEPRC PSDCSDRGLC
IDGECVCEEA FAGEDCSLGR CLNDCSDQGA CVNGSCQCRS GFLGEDCSLI FCANNCSQRG
VCKEGFCVCQ EGYTGDDCTS VLPPMNLRVR GVSENTIDLQ WEGPAILTDY LITYEPTTPG
GVQLEMRVPG NVTNITIKGL NPGLEYNVNV YAVIDNIISS PMNTLVSTYL SNPDGLLFKS
IMETSVEVQW QPLDYLFDGW EISFIPKDND GGMTAQLPST ITSFHQTGLK PGEEYTVNLV
ALKDQGRSLP VTATVTTLID GPIQLIVRDI SDTVAFVEWS PPKAKVDQII LRYGLVGVEG
PKTTFRLQPT LSQYSLQVLR PGSTYEVSVS GVRNGTESGV ISTEFTTEID APKNLRVLSK
TSISLELEWD NSEADVEGYS VVYSTLAGDQ YDKVIVPRND GPSTKTTLNE LMPGTEYGIG
ISAVLGANQS TPATMNARTG LDVPLDLTVT ASTDNTITLL WGTVQGPIDH YRVTYTSSSG
VTTELTVPKD VTTTTLTSLQ PGTEYTITVA AQRGRQQSTA ATIDAFTGFR PITQLFFSEV
SSDSLTVAWS SPAPPADAFI LNYSAQDSSE DSEIALDGSK TRITLTGLMP SRRYTATLVT
MHGNVTSKPV VGSVNTGMDP PRDITVLYVT EESVTITWIQ PLALLDYYRM SYQSSKGRMD
SVVIDSDINN YTLTSLHPAT EYEIKLNAVR GSQESKVITT TVFTAIDMPA ELTALNVTPQ
GALLRWNPPA SSVDNYVLTV TRNQVTADTF LVEGNKQEYQ LSQLIPSTTY SVALYATKGP
LTSGTVISNF VTPMDAPQNL TASEINHRSA LISWQPPIAD IDNYMLTYKA ADGSRKELIL
DAEDTWIRLE GLAETTEYTV RLQVARGLET SVIVSTSFTT GNRLFPTPQN CAQHLLNGET
LGGIYTIYVN RDLSQGVQVY CDMTTDGGGW IVFQRRQNGL TDFSRKWTDY KIGFGSLEDE
FWLGLDNIHK IAAQGRYELR IDMKDGQESV YANYDRFSIG DSKSLYKLRI GEYSGTAGDS
LSYHQSRPFS TKDKDNDIAV TNCALSYKGA WWYKNCHRAN LNGKYGESRH SQGINWYHWK
GHEFSIPFVE MKMRPFNYRS ISGKRRRSAH
//