ID Q7THT5_HHV1 Unreviewed; 311 AA.
AC Q7THT5;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Virion host shutoff protein {ECO:0000256|ARBA:ARBA00018606};
DE Flags: Fragment;
OS Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus humanalpha1.
OX NCBI_TaxID=10298 {ECO:0000313|EMBL:AAP39043.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAP39043.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S026 {ECO:0000313|EMBL:AAP39043.1};
RA Bowden R.J.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAP39043.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S026 {ECO:0000313|EMBL:AAP39043.1};
RX PubMed=16376841; DOI=10.1016/j.meegid.2005.01.004;
RA Bowden R., Sakaoka H., Ward R., Donnelly P.;
RT "Patterns of Eurasian HSV-1 molecular diversity and inferences of human
RT migrations.";
RL Infect. Genet. Evol. 6:63-74(2006).
CC -!- SUBUNIT: Interacts with human EIF4H, EIF4A1 and EIF4A2; interaction
CC with eIF4AI and EIF4A2 presumably allows Vhs protein to associate with
CC the eIF4F cap-binding complex. {ECO:0000256|ARBA:ARBA00011134}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the herpesviridae VHS protein family.
CC {ECO:0000256|ARBA:ARBA00009669}.
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DR EMBL; AY240544; AAP39043.1; -; Genomic_DNA.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0039595; P:induction by virus of catabolism of host mRNA; IEA:UniProtKB-KW.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR Pfam; PF00867; XPG_I; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 3: Inferred from homology;
KW Decay of host mRNAs by virus {ECO:0000256|ARBA:ARBA00022616};
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host mRNA suppression by virus {ECO:0000256|ARBA:ARBA00022557};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00023258};
KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00023258};
KW Late protein {ECO:0000256|ARBA:ARBA00022921};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT DOMAIN 12..83
FT /note="XPG-I"
FT /evidence="ECO:0000259|Pfam:PF00867"
FT REGION 107..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAP39043.1"
SQ SEQUENCE 311 AA; 35495 MW; F8300F94EAE4D416 CRC64;
RALGYAYINS GQLEADDACA NLYHTNTVAY VYTTDTDLLL MGCDIVLDIS ACYIPTINCR
DILKYFKMSY PQFLALFVRC HTDLHPNNTY ASVEDVLREC HWTPPSRSQT RRAIRREHTS
SRSTETRPPL PPAAGGTETR VSWTEILTQQ IAGGYEDDED LPLDPRDVTG GHPGPRSSSS
EILTPPELVQ VPNAQLLEEH RSYVASRRRH VIHDAPESLD WLPDPMTITE LVEHRYIKYV
ISLIGPKERG PWTLLKRLPI YQDIRDENLA RSIVTRHITA PDIADRFLEQ LRTQAPPPAF
YKDVLAKFWD E
//
