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Database: UniProt
Entry: Q7TNG5
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Original site: Q7TNG5 
ID   EMAL2_MOUSE             Reviewed;         649 AA.
AC   Q7TNG5; Q9DAS8;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   09-JUL-2014, entry version 92.
DE   RecName: Full=Echinoderm microtubule-associated protein-like 2;
DE            Short=EMAP-2;
GN   Name=Eml2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Placenta;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=FVB/N; TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May modify the assembly dynamics of microtubules, such
CC       that microtubules are slightly longer, but more dynamic (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q7TNG5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7TNG5-2; Sequence=VSP_024480;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC   -!- SIMILARITY: Contains 11 WD repeats.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB24122.1; Type=Frameshift; Positions=32;
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DR   EMBL; AK005562; BAB24122.1; ALT_FRAME; mRNA.
DR   EMBL; BC055476; AAH55476.1; -; mRNA.
DR   CCDS; CCDS52055.1; -. [Q7TNG5-2]
DR   RefSeq; NP_001156468.1; NM_001162996.1. [Q7TNG5-1]
DR   RefSeq; NP_082429.1; NM_028153.1. [Q7TNG5-2]
DR   UniGene; Mm.154121; -.
DR   ProteinModelPortal; Q7TNG5; -.
DR   SMR; Q7TNG5; 103-646.
DR   IntAct; Q7TNG5; 1.
DR   MINT; MINT-5085024; -.
DR   STRING; 10090.ENSMUSP00000112491; -.
DR   PhosphoSite; Q7TNG5; -.
DR   MaxQB; Q7TNG5; -.
DR   PaxDb; Q7TNG5; -.
DR   PRIDE; Q7TNG5; -.
DR   Ensembl; ENSMUST00000048502; ENSMUSP00000037654; ENSMUSG00000040811. [Q7TNG5-2]
DR   GeneID; 72205; -.
DR   KEGG; mmu:72205; -.
DR   UCSC; uc009fkz.2; mouse. [Q7TNG5-1]
DR   UCSC; uc009fla.2; mouse. [Q7TNG5-2]
DR   CTD; 24139; -.
DR   MGI; MGI:1919455; Eml2.
DR   eggNOG; COG2319; -.
DR   GeneTree; ENSGT00550000074369; -.
DR   HOGENOM; HOG000294061; -.
DR   HOVERGEN; HBG051470; -.
DR   InParanoid; Q7TNG5; -.
DR   TreeFam; TF317832; -.
DR   NextBio; 335691; -.
DR   PRO; PR:Q7TNG5; -.
DR   ArrayExpress; Q7TNG5; -.
DR   Bgee; Q7TNG5; -.
DR   CleanEx; MM_EML2; -.
DR   Genevestigator; Q7TNG5; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR011047; Quinonprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   Pfam; PF03451; HELP; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 11.
DR   SUPFAM; SSF50998; SSF50998; 5.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton;
KW   Microtubule; Reference proteome; Repeat; WD repeat.
FT   CHAIN         1    649       Echinoderm microtubule-associated
FT                                protein-like 2.
FT                                /FTId=PRO_0000284388.
FT   REPEAT      103    152       WD 1.
FT   REPEAT      157    200       WD 2.
FT   REPEAT      203    242       WD 3.
FT   REPEAT      250    288       WD 4.
FT   REPEAT      292    331       WD 5.
FT   REPEAT      375    414       WD 6.
FT   REPEAT      416    455       WD 7.
FT   REPEAT      458    497       WD 8.
FT   REPEAT      504    543       WD 9.
FT   REPEAT      571    610       WD 10.
FT   REPEAT      616    649       WD 11.
FT   VAR_SEQ      61     61       Y -> YPLTSSLSALLEEALGFSSY (in isoform 2).
FT                                /FTId=VSP_024480.
FT   CONFLICT    251    251       K -> R (in Ref. 1; BAB24122).
SQ   SEQUENCE   649 AA;  70734 MW;  7B85AE89FE9ECAAC CRC64;
     MSSFGIGKTK EVIFSMEEGS VKMFLRGRPV PMLIPDELAP TYSLDTRSEL PSSRLKLDWV
     YGYRGRDCRA NLYLLPTGEV VYFVASVAVL YSVEEQRQRH YLGHNDDIKC LAVHPDMVTI
     ATGQVAGTTK EGKPLPPHVR VWDSVSLSTL HVLGLGVFDR AVCCVAFSKS NGGNLLCAVD
     ESNDHVLSVW DWAKESKVVD SKCSNEAVLV ATFHPTDPSL LITCGKSHIY FWSLEGGSLS
     KRQGLFEKHE KPKYVLCVTF LEGGDVVTGD SGGNLYVWGK GGNRITQEVQ GAHDGGVFAL
     CALRDGTLVS GGGRDRRVVL WGSDYSKVQE VEVPEDFGPV RTVAEGRGDT LYVGTTRNSI
     LLGSVHTGFS LLVQGHVEEL WGLATHPSRA QFVTCGQDKL VHLWSSETHQ PVWSRSIEDP
     ARSAGFHPSG SVLAVGTVTG RWLLLDTETH DLVAIHTDGN EQISVVSFSP DGAYLAVGSH
     DNLVYVYTVD QGGRKVSRLG KCSGHSSFIT HLDWAQDSTC FVTNSGDYEI LYWDPVTCKQ
     ITSADTVRNV EWATATCVLG FGVFGIWPEG ADGTDINAVA RSHDGKLLVS ADDFGKVHLF
     SYPCCQPRAL SHKYGGHSSH VTNVAFLWDD SMALTTGGKD TSVLQWRVA
//
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