ID EMAL2_MOUSE Reviewed; 649 AA.
AC Q7TNG5; Q9DAS8;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 01-MAY-2013, entry version 81.
DE RecName: Full=Echinoderm microtubule-associated protein-like 2;
DE Short=EMAP-2;
GN Name=Eml2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such
CC that microtubules are slightly longer, but more dynamic (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7TNG5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7TNG5-2; Sequence=VSP_024480;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC -!- SIMILARITY: Contains 11 WD repeats.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB24122.1; Type=Frameshift; Positions=32;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK005562; BAB24122.1; ALT_FRAME; mRNA.
DR EMBL; BC055476; AAH55476.1; -; mRNA.
DR IPI; IPI00663323; -.
DR IPI; IPI00665769; -.
DR RefSeq; NP_001156468.1; NM_001162996.1.
DR RefSeq; NP_082429.1; NM_028153.1.
DR UniGene; Mm.154121; -.
DR ProteinModelPortal; Q7TNG5; -.
DR SMR; Q7TNG5; 72-649.
DR STRING; 10090.ENSMUSP00000112491; -.
DR PhosphoSite; Q7TNG5; -.
DR PaxDb; Q7TNG5; -.
DR PRIDE; Q7TNG5; -.
DR Ensembl; ENSMUST00000048502; ENSMUSP00000037654; ENSMUSG00000040811.
DR GeneID; 72205; -.
DR KEGG; mmu:72205; -.
DR UCSC; uc009fkz.2; mouse.
DR UCSC; uc009fla.2; mouse.
DR CTD; 24139; -.
DR MGI; MGI:1919455; Eml2.
DR eggNOG; COG2319; -.
DR GeneTree; ENSGT00550000074369; -.
DR HOGENOM; HOG000294061; -.
DR HOVERGEN; HBG051470; -.
DR InParanoid; Q7TNG5; -.
DR OrthoDB; EOG4CC40Q; -.
DR NextBio; 335691; -.
DR ArrayExpress; Q7TNG5; -.
DR Bgee; Q7TNG5; -.
DR CleanEx; MM_EML2; -.
DR Genevestigator; Q7TNG5; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0008152; P:metabolic process; IEA:GOC.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinonprotein_ADH-like_supfam.
DR InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR017986; WD40_repeat_dom.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 11.
DR SUPFAM; SSF50998; Quin_alc_DH_like; 1.
DR SUPFAM; SSF50952; Quino_gluc_DH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; FALSE_NEG.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton;
KW Microtubule; Reference proteome; Repeat; WD repeat.
FT CHAIN 1 649 Echinoderm microtubule-associated
FT protein-like 2.
FT /FTId=PRO_0000284388.
FT REPEAT 103 152 WD 1.
FT REPEAT 157 200 WD 2.
FT REPEAT 203 242 WD 3.
FT REPEAT 250 288 WD 4.
FT REPEAT 292 331 WD 5.
FT REPEAT 375 414 WD 6.
FT REPEAT 416 455 WD 7.
FT REPEAT 458 497 WD 8.
FT REPEAT 504 543 WD 9.
FT REPEAT 571 610 WD 10.
FT REPEAT 616 649 WD 11.
FT VAR_SEQ 61 61 Y -> YPLTSSLSALLEEALGFSSY (in isoform 2).
FT /FTId=VSP_024480.
FT CONFLICT 251 251 K -> R (in Ref. 1; BAB24122).
SQ SEQUENCE 649 AA; 70734 MW; 7B85AE89FE9ECAAC CRC64;
MSSFGIGKTK EVIFSMEEGS VKMFLRGRPV PMLIPDELAP TYSLDTRSEL PSSRLKLDWV
YGYRGRDCRA NLYLLPTGEV VYFVASVAVL YSVEEQRQRH YLGHNDDIKC LAVHPDMVTI
ATGQVAGTTK EGKPLPPHVR VWDSVSLSTL HVLGLGVFDR AVCCVAFSKS NGGNLLCAVD
ESNDHVLSVW DWAKESKVVD SKCSNEAVLV ATFHPTDPSL LITCGKSHIY FWSLEGGSLS
KRQGLFEKHE KPKYVLCVTF LEGGDVVTGD SGGNLYVWGK GGNRITQEVQ GAHDGGVFAL
CALRDGTLVS GGGRDRRVVL WGSDYSKVQE VEVPEDFGPV RTVAEGRGDT LYVGTTRNSI
LLGSVHTGFS LLVQGHVEEL WGLATHPSRA QFVTCGQDKL VHLWSSETHQ PVWSRSIEDP
ARSAGFHPSG SVLAVGTVTG RWLLLDTETH DLVAIHTDGN EQISVVSFSP DGAYLAVGSH
DNLVYVYTVD QGGRKVSRLG KCSGHSSFIT HLDWAQDSTC FVTNSGDYEI LYWDPVTCKQ
ITSADTVRNV EWATATCVLG FGVFGIWPEG ADGTDINAVA RSHDGKLLVS ADDFGKVHLF
SYPCCQPRAL SHKYGGHSSH VTNVAFLWDD SMALTTGGKD TSVLQWRVA
//
