ID Q7TP67_RAT Unreviewed; 1683 AA.
AC Q7TP67; A0A0G2K5D3;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=Ab2-008 {ECO:0000313|EMBL:AAP92581.1};
DE SubName: Full=Poly (ADP-ribose) polymerase family, member 4 {ECO:0000313|Ensembl:ENSRNOP00000073383.2};
GN Name=Mphosph8 {ECO:0000313|RGD:1305133};
GN Synonyms=Parp4 {ECO:0000313|Ensembl:ENSRNOP00000073383.2,
GN ECO:0000313|RGD:1310524};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAP92581.1};
RN [1] {ECO:0000313|EMBL:AAP92581.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu C.S., Li W.Q., Li Y.C., Wang S.F., Han H.P., Wang G.P., Chai L.Q.,
RA Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Ma H., Wang L.,
RA Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT "Liver regeneration after PH.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000073383.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073383.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000073383.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073383.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AY325180; AAP92581.1; -; mRNA.
DR STRING; 10116.ENSRNOP00000073383; -.
DR PaxDb; 10116-ENSRNOP00000040476; -.
DR Ensembl; ENSRNOT00000090573.2; ENSRNOP00000073383.2; ENSRNOG00000061152.2.
DR UCSC; RGD:1305133; rat.
DR AGR; RGD:1310524; -.
DR RGD; 1305133; Mphosph8.
DR RGD; 1310524; Parp4.
DR VEuPathDB; HostDB:ENSRNOG00000061152; -.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG1911; Eukaryota.
DR GeneTree; ENSGT00940000160555; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Bgee; ENSRNOG00000061152; Expressed in thymus and 19 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005876; C:spindle microtubule; ISO:RGD.
DR GO; GO:0019899; F:enzyme binding; ISO:RGD.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; ISO:RGD.
DR GO; GO:1990404; F:NAD+-protein ADP-ribosyltransferase activity; ISO:RGD.
DR GO; GO:0006954; P:inflammatory response; ISO:RGD.
DR GO; GO:0036211; P:protein modification process; ISO:RGD.
DR CDD; cd18633; CD_MMP8; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR031273; PARP4.
DR PANTHER; PTHR46530; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4; 1.
DR PANTHER; PTHR46530:SF1; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00385; Chromo; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
PE 1: Evidence at protein level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q7TP67};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 867..917
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REPEAT 1399..1431
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1432..1464
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1465..1497
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 404..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..982
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1067
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1683 AA; 188816 MW; A9F7B6E76850A19E CRC64;
MARIHSPSCH SVSVKWQQLS RDAPEPLQAP TCVPSLFHND RLLVYGFIPH CTQASLCAFI
QEKEFCTMVS TTELQKTTGT VACFLLTPWV IWCCLHVHQY RFYSSTSGPA GNISEANGLF
LLPTASSCQQ LLSRGWLHLA GLAYAMIHKL AARALIRDYE DGILHDNETN HEMKKNIMKS
LIIELSKENS LITQFTSFVA VEKRDVNEVP LANAPSISEL VAKEDVDFLP YVSWQEKQPE
TFTSQPFSIS SEGNEELSLL TAAKKCKVKT RKMRNLKVSE DFEGTPAMAQ SPTTAQSDFH
LPLSVCPQPV KLKKGRKFQK LRMADEPRKA PVSMVSSAPA VTAGFSFLSA RHSSSAFLSP
LCNISLPPPP PPLPGFIPTN SCRPMSNYSH KLAKATDICD SEPPLRGFRG ASPKDTSSRG
TGFRGGTFSD SFAGSKDFDP GKFSQDLNNI VSSPKAPELA ATQRSPLRSP PKPLSVPPLV
VCEFSSELPQ SHSFHFQSGS VHRSPNYRMS DMASLRSALS LDYSAWDCVL EEADSLDGGS
FETETDEAAA YTACEFLTSM ETPSHEEFVI GDDEGRQSPV SWTSLFALQT EDGFWKLTPE
LGLILKLNVN ALLNSLEEKG IRSLGTKGRE RLLDLIATLL VLQFLYTKLE QEGMAAKSLI
KMDDVLISRS CFNSVCLILR SPIKILHQNS PPDLELDHLP PLQKQVLLFH PQIVHEELQP
VSNWLYAIDS TTDTIYASQN RIKPFDPPIH FPRTPQGSWE RPFAGLATLC VNPRLDAHNW
LASPTVESRR RSGLGRSGQR AELSRPFVMA AATEENMSVA ALVMSVPDNI GRSPEVEGGG
AAGEEKDAAT KGTVAVGDSE EDGEDVFEVE RILDMKCEGG KNLYKVRWKG YTSDDDTWEP
EVHLEDCKEV LLEFRKKVAE NKAKAVRKDI QKLSLNNDIF EADSDIDQQG DTKEDTSPRK
KKKKIKYKED KSPDDLRKKR AKMGKLKDKF KTELESTSEI LGFDVKTKKR ILEVKEELKD
SKKPKKDEIK ETKKTKRADI RDLKIKIRED VKDNRKTKKE RYIDSPLESE SPNDSFTLED
ESEDFLSDNK EKQNVRTAKD KTGQDTVQES IFEKHLDDLI SIEEAGTRVR RKKKQPRKFE
EPKEIKKLEN TNNFLERKMI PKKQRNQDKG RSNPELSKLP SPVFAQTMKS LRLSGEEKGL
KSSDLAEEEK ERKNEPKEKY QKRYDFDKEE KARKEPKGLK SFKEIRNAFD LFKKTAEEKN
DLENNSKREE ISLDYKITHD NKTKDKCSLR EERNTRDETD TWAYIAAEGD QEVSDSVCQT
DESSDGKQPI LSLGMDLQLE WMKLEDFQKH LDGEDEPFIT ANRIPSNLLR DAVKNGDYIA
VKVALNSNEE YNLDQEDSTG MTLVMLAAAG GQDDLLRLLI TKGAKVNGRQ KNGTTALIHA
AEKNFLTTVA ILLEAGAFVN VQQSNGETAL MKACKRGNSD IVRLVIECGA DCNILSKHQN
SALYFAKQCN NVLVYELLKS HLETLSRVAE ETIRDYFESR LALLEPVFPI ACHRLCEGPD
FSTDFNYMPP QNMPEGSGVL LFIFHANFLG KDVIARLCGP CSVQAVVLND KFQLPVFLDS
HFVYSFSPVA GPNKLFIRLT EAPFAKLIGH QLLWTGDVSM QYTTDVLHSR NVSCGMQTST
LAP
//
