ID NAGZ_SHIFL Reviewed; 341 AA.
AC Q7UCW4; Q83LH8;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2004, sequence version 2.
DT 01-MAY-2013, entry version 71.
DE RecName: Full=Beta-hexosaminidase;
DE EC=3.2.1.52;
DE AltName: Full=Beta-N-acetylhexosaminidase;
DE AltName: Full=N-acetyl-beta-glucosaminidase;
GN Name=nagZ; OrderedLocusNames=SF1111, S1191;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/IAI.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W.,
RA Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A.,
RA Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S.,
RA Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella
RT flexneri serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H.,
RA Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J.,
RA Sun L., Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S.,
RA Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y.,
RA Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
CC -!- FUNCTION: Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: Hydrolysis of terminal non-reducing N-acetyl-
CC D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan recycling.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 3 family. NagZ
CC subfamily.
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DR EMBL; AE014073; AAP16617.1; -; Genomic_DNA.
DR EMBL; AE005674; AAN42729.1; -; Genomic_DNA.
DR RefSeq; NP_707022.1; NC_004337.2.
DR RefSeq; NP_836811.1; NC_004741.1.
DR ProteinModelPortal; Q7UCW4; -.
DR SMR; Q7UCW4; 1-325.
DR STRING; 198214.SF1111; -.
DR PaxDb; Q7UCW4; -.
DR EnsemblBacteria; AAN42729; AAN42729; SF1111.
DR EnsemblBacteria; AAP16617; AAP16617; S1191.
DR GeneID; 1024077; -.
DR GeneID; 1077595; -.
DR KEGG; sfl:SF1111; -.
DR KEGG; sfx:S1191; -.
DR PATRIC; 18703590; VBIShiFle31049_1300.
DR eggNOG; COG1472; -.
DR HOGENOM; HOG000248526; -.
DR KO; K01207; -.
DR OMA; VVLHCNG; -.
DR ProtClustDB; PRK05337; -.
DR UniPathway; UPA00544; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:HAMAP.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009254; P:peptidoglycan turnover; IEA:HAMAP.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.300; -; 1.
DR HAMAP; MF_00364; NagZ; 1; -.
DR InterPro; IPR022956; Beta_hexosaminidase_bac.
DR InterPro; IPR019800; Glyco_hydro_3_AS.
DR InterPro; IPR001764; Glyco_hydro_3_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR Pfam; PF00933; Glyco_hydro_3; 1.
DR SUPFAM; SSF51445; Glyco_hydro_cat; 1.
DR PROSITE; PS00775; GLYCOSYL_HYDROL_F3; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell shape;
KW Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;
KW Glycosidase; Hydrolase; Peptidoglycan synthesis.
FT CHAIN 1 341 Beta-hexosaminidase.
FT /FTId=PRO_0000210799.
FT ACT_SITE 248 248 By similarity.
SQ SEQUENCE 341 AA; 37602 MW; 3233785CE886F9ED CRC64;
MGPVMLDVEG YELDAEEREI LAHPLVGGLI LFTRNYHDPA QLRELVRQIR AASRNHLVVA
VDQEGGRVQR FREGFTRLPA AQSFAALLGM EEGGKLAQEA GWLMASEMIA MDIDISFAPV
LDVGHISAAI GERSYHADPQ KALAIASRFI DGMHEAGMKT TGKHFPGHGA VTADSHKETP
CDPRPQAEIR AKDMSVFSSL IRENKLDAIM PAHVIYSDVD PRPASGSPYW LKTVLRQELG
FDGVIFSDDL SMEGAAIMGS YAERGQASLD AGCDMILVCN NRKGAVSVLD NLSPIKAERV
TRLYHKGSFS RQELMDSARW KAISTRLNQL HERWQEEKAG H
//
