ID Q7VGG3_HELHP Unreviewed; 704 AA.
AC Q7VGG3;
DT 01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=HH_1358 {ECO:0000313|EMBL:AAP77955.1};
OS Helicobacter hepaticus (strain ATCC 51449 / 3B1).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=235279 {ECO:0000313|EMBL:AAP77955.1, ECO:0000313|Proteomes:UP000002495};
RN [1] {ECO:0000313|EMBL:AAP77955.1, ECO:0000313|Proteomes:UP000002495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51449 / 3B1 {ECO:0000313|Proteomes:UP000002495};
RX PubMed=12810954; DOI=10.1073/pnas.1332093100;
RA Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M.,
RA Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R.,
RA Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B.,
RA Shen Z., Weber J., Frosch M., Fox J.G.;
RT "The complete genome sequence of the carcinogenic bacterium Helicobacter
RT hepaticus.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; AE017125; AAP77955.1; -; Genomic_DNA.
DR RefSeq; WP_011116198.1; NC_004917.1.
DR AlphaFoldDB; Q7VGG3; -.
DR STRING; 235279.HH_1358; -.
DR GeneID; 82135898; -.
DR KEGG; hhe:HH_1358; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_2_7; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000002495; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000002495}.
FT DOMAIN 21..294
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 295..561
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 42..49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 704 AA; 80456 MW; 423A7C06A8D40113 CRC64;
MPVSLSSVQP LVPQTLEQTI VSLNDAQKQA VEHIDGAMLI LAGAGSGKTK TITTRLAYLI
DEVGIPPSAT LTLTFTNKAA QEMRERALTL LHNRYESPPL LCTFHRFGLL FLRFHITALG
RNANFVVLDT DDKRAILKSL CKIRPISQLD YYISDMKNAF LSPEQAQTYA HSEEYKLMNR
IYGEYENYLL NKNLLDFDDL LYLTYAILLK NDNIAKQMSE KYHYIMVDEY QDTNEIQYKI
LKRLCLAHTN LCVVGDDDQS IYGWRGANVK NILGFPKEFD EVKVVKLEEN YRSSEQILNA
ANALISHNSK RLGKNLKSIK GAGANVRVIE SENESTEAEF LAKDILTLLS QGINPSEIAV
LFRVNALSRS IEEGFNRAKI PYKIIGAVRF YERAEIKDLL CYLRLIVNPN DDYSFLRIIN
RPRRGIGKIT QLKLEELART FNTSCFSSIT QYTQQSKEAI GEKAYNALLE LTQNIERWRK
YTDLADVIED MQEHIVFTFS RLDEVDRKGN IEEFYGMFRD YAIANPSNQV EDFLNDIALA
SPTDELTGEY VSCMSIHMAK GLEFKYVYVI GFEEGIFPLW NDEDEIQEER RLGYVAITRA
KDFLTLCSAK SRLRRGKREW LEQSRFLRES GLLGVYNAPS LYKTQSIQEE AEVVFSKGMK
VQHKLFGVGV VESIKGKGSQ CQLRINFSGL ERVILASFVQ KVCE
//
