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Database: UniProt
Entry: Q7VLL3
LinkDB: Q7VLL3
Original site: Q7VLL3 
ID   UVRB_HAEDU              Reviewed;         675 AA.
AC   Q7VLL3;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   01-OCT-2014, entry version 72.
DE   RecName: Full=UvrABC system protein B {ECO:0000255|HAMAP-Rule:MF_00204};
DE            Short=Protein UvrB {ECO:0000255|HAMAP-Rule:MF_00204};
DE   AltName: Full=Excinuclease ABC subunit B {ECO:0000255|HAMAP-Rule:MF_00204};
GN   Name=uvrB {ECO:0000255|HAMAP-Rule:MF_00204};
GN   OrderedLocusNames=HD_1416;
OS   Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=233412;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=35000HP / ATCC 700724;
RA   Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R.,
RA   Johnson L., Nguyen D., Wang J., Forst C., Hood L.;
RT   "The complete genome sequence of Haemophilus ducreyi.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. A damage recognition complex composed
CC       of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon
CC       binding of the UvrA(2)B(2) complex to a putative damaged site, the
CC       DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP
CC       binding by UvrB and probably causes local melting of the DNA
CC       helix, facilitating insertion of UvrB beta-hairpin between the DNA
CC       strands. Then UvrB probes one DNA strand for the presence of a
CC       lesion. If a lesion is found the UvrA subunits dissociate and the
CC       UvrB-DNA preincision complex is formed. This complex is
CC       subsequently bound by UvrC and the second UvrB is released. If no
CC       lesion is found, the DNA wraps around the other UvrB subunit that
CC       will check the other stand for damage. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC       lesions. Interacts with UvrC in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- DOMAIN: The beta-hairpin motif is involved in DNA binding.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Belongs to the UvrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Contains 1 UVR domain. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
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DR   EMBL; AE017143; AAP96222.1; -; Genomic_DNA.
DR   RefSeq; NP_873833.1; NC_002940.2.
DR   ProteinModelPortal; Q7VLL3; -.
DR   SMR; Q7VLL3; 8-599.
DR   STRING; 233412.HD1416; -.
DR   EnsemblBacteria; AAP96222; AAP96222; HD_1416.
DR   GeneID; 1491302; -.
DR   KEGG; hdu:HD1416; -.
DR   PATRIC; 20179098; VBIHaeDuc133973_1183.
DR   eggNOG; COG0556; -.
DR   KO; K03702; -.
DR   OMA; GDDWLIM; -.
DR   OrthoDB; EOG6B360R; -.
DR   BioCyc; HDUC233412:GH5F-1280-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.50.300; -; 4.
DR   Gene3D; 4.10.860.10; -; 1.
DR   HAMAP; MF_00204; UvrB; 1.
DR   InterPro; IPR006935; Helicase/UvrB_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR004807; UvrB.
DR   InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR   PANTHER; PTHR24029; PTHR24029; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF12344; UvrB; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF52540; SSF52540; 3.
DR   TIGRFAMs; TIGR00631; uvrb; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision;
KW   DNA repair; Excision nuclease; Nucleotide-binding; Reference proteome;
KW   SOS response.
FT   CHAIN         1    675       UvrABC system protein B.
FT                                /FTId=PRO_0000138394.
FT   DOMAIN       29    414       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      434    600       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_00204}.
FT   DOMAIN      636    671       UVR. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   NP_BIND      42     49       ATP. {ECO:0000255|HAMAP-Rule:MF_00204}.
FT   MOTIF        95    118       Beta-hairpin.
SQ   SEQUENCE   675 AA;  76609 MW;  71F2C9760DEFE2D6 CRC64;
     MSKPGKPFIL NSPFAPSGDQ PSAIKKLTEG LQDGLAHQTL LGVTGSGKTF TIANVIAQLN
     RPAMLLAPNK TLAAQLYAEM KAFFPENAVE YFVSYYDYYQ PEAYVPASDT FIEKDASINE
     QIEQMRLSAT KSFLERRDTI VVASVSAIYG LGDVNAYMQM MLHLQVGAII NQRDILARLA
     ELQYTRNDQA FQRSTFRVRG EVIDIFPAES DEIALRIELF DDEIDNLSLF DPLTGHSFGK
     IPRYTIYPKT HYVTPRERIL TAIDQIKNEL TGRQDYFIKE HKLLEEQRIT QRTQFDIEMI
     NELGYCSGIE NYSRYLSGRQ EGEPPPTLFD YMPADGLLII DESHVTVPQI GGMYRGDRAR
     KETLVQYGFR LPSALDNRPL KFEEFERLSP QTIYVSATPG NYELEKSNGD IIDQVVRPTG
     LLDPIIEVRP VASQVDDVLS EIQQRVALDE RVLITTLTKK MAEDLTDYLD EHGVRVRYLH
     SDIDTVERVE IIHDLRIGMF DVLVGINLLR EGLDMPEVAL VAILDADKEG FLRSESSLIQ
     TIGRAARNLN GKAILYADRI THSMQKAITE TERRREKQQK YNQEHNIIPQ ALNKKVRELL
     DIGQTDKQKK GKQAVKIAEQ SASYTPNAPK SRQALEKELK QLTQQMQKLA KDLEFEKAAA
     VRDKIGQLKM ALLEV
//
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