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Database: UniProt
Entry: Q7Z002_CAEEL
LinkDB: Q7Z002_CAEEL
Original site: Q7Z002_CAEEL 
ID   Q7Z002_CAEEL            Unreviewed;      1852 AA.
AC   Q7Z002;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   27-SEP-2017, entry version 123.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=cca-1 {ECO:0000313|EMBL:CCD68018.1,
GN   ECO:0000313|WormBase:C54D2.5c};
GN   ORFNames=C54D2.5 {ECO:0000313|WormBase:C54D2.5c}, CELE_C54D2.5
GN   {ECO:0000313|EMBL:CCD68018.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:AAP79883.1};
RN   [1] {ECO:0000313|EMBL:CCD68018.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD68018.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000313|EMBL:CCD68018.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD68018.1};
RA   Alber B.E., Fuchs G.;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAP79883.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Steger K.A., Thacker C., Snutch T.P., Avery L.;
RT   "cca-1 encodes a T-type calcium channel required for effective
RT   neuromuscular signaling in the C. elegans pharynx.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:CCD68018.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD68018.1};
RG   WormBase Consortium;
RA   WormBase;
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; AY313900; AAP79883.1; -; mRNA.
DR   EMBL; BX284606; CCD68018.1; -; Genomic_DNA.
DR   RefSeq; NP_001024496.1; NM_001029325.2.
DR   UniGene; Cel.19373; -.
DR   EnsemblMetazoa; C54D2.5c; C54D2.5c; WBGene00000367.
DR   GeneID; 181045; -.
DR   UCSC; C54D2.5e; c. elegans.
DR   CTD; 181045; -.
DR   WormBase; C54D2.5c; CE36115; WBGene00000367; cca-1.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   HOGENOM; HOG000007742; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00000367; -.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; ISS:WormBase.
DR   GO; GO:0051899; P:membrane depolarization; IMP:WormBase.
DR   GO; GO:0045760; P:positive regulation of action potential; IMP:WormBase.
DR   GO; GO:0043051; P:regulation of pharyngeal pumping; IMP:WormBase.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   2: Evidence at transcript level;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    174    193       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    267    290       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    391    409       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    429    455       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    690    710       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    778    799       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    820    836       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    856    882       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1112   1130       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1150   1171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1183   1202       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1248   1270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1351   1374       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1457   1478       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1490   1508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1520   1538       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1587   1606       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1675   1700       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      130    461       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      657    889       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1111   1383       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1456   1710       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      879    910       {ECO:0000256|SAM:Coils}.
FT   COILED     1045   1072       {ECO:0000256|SAM:Coils}.
FT   COILED     1374   1404       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1852 AA;  211761 MW;  0B9AD44623A10513 CRC64;
     MLRQPVPELR SFQSLSKYAG GPRSVLGRRT SAITVNRRQS QSTRRHEDVE ALGSIEGSKE
     TLQLSEHGRL ASSSEASPSR WEGRQIEWGN EEQIEEESEL PYPGFAEPAL RCFYQARPPR
     KWALQMVMSP WFDRITMAVI MINCVTLGMY RPCEDGPDCD TYRCQILDII DNCIFVYFAF
     EMVIKIMALG FYGPAAYMSD TWNRLDFFIV MAGIAEFVLH EYLGGNINLT AIRTVRVLRP
     LRAVNRIPSM RILVNLLLDT LPMLGNVLLL CFFVFFIFGI VGVQLWAGLL RNRCVINLPK
     TISENQSALF NNVKLTRFYI PEDTSLEYIC SQPDANGLHT CSNLPPYTVD GVKCNLTLDE
     YDKVTNDSCI NWNIYYNECQ VMQRNPFQGS VSFDNIGFAW VAIFLVISLE GWTDIMYYVQ
     DAHSFWNWIY FVLLIVIGAF FMINLCLVVI ATQFAETKRR ETERMLQERK MLLNRDSISC
     TGSEIGGASS KEEGDTVYAA FVRFIGHTFR RTKRAAKKKY TAYMEERAER KSSERQQRRK
     SKLDDMATLS RIEEKAEDEE DETTITRENG DDQIEQNGDG VRIKRVKIEE EPKIKIGNGN
     SNGPHYKHSS SDEESDEDGE EDQVYDGEEA KKKSTPSKLW WFREKIQKFV ICDHFTRGIL
     VAILVNTLSM GVEYHQQPEI LTVILEYSNL FFTALFALEM LLKIIASGLF GYLADGFNLF
     DGGIVALSVL ELFQEGKGGL SVLRTFRLLR ILKLVRFMPA LRYQLVVMLR TMDNVTVFFG
     LLVLFIFIFS ILGMNLFGCK FCKVEEKFLG GLAKKCERKN FDTLLWALIT VFQILTQEDW
     NMVLFNGMAQ TNPWAALYFV ALMTFGNYVL FNLLVAILVE GFQESKEEEK RQLEEDARKQ
     AVEEEDERKR ELELIIAKTT SPAFNNGVAP AECTCQRPSS PEESPSPRLL SANYHPSPER
     KHSANLDAII DKRLVLRNSA PFDRSPVSEG RDDSRLNRHA SLVLPVANGV PYRRQRVHSW
     SGLCHHFNPN CPVHGRRALI ETYAREKFLE ASQELKQALA EEEKRNEAKQ NTFVRKLLKK
     TCLHNRTEFS LFLMGPKNPL RIKCLQTTQK KWFDYTVLFF IGINCITLAM ERPSIPPDSF
     ERQFLHISGY IFTVIFTGEM MMKVIANGCF IGQAAYFKDG WNILDGILVV ISLINIAFEL
     LATGDSPKIF GVIRVLRLLR ALRPLRVINR APGVKLVVMT LISSLKPIGN IVLICCTFFI
     IFGILGVQLF KGMMYHCIGP EVGNVTTKAD CIEDYRNKWV NHRYNFDNLG QALMSLFVLS
     SKDGWVSIMY QGIDAVGVDV QPIENYNEWR MIYFISFLLL VGFFVLNMFV GVVVENFHKC
     KEALEKEMRE KEKEKRLKRK LKRQKFEESM AGKRKKNRIV WAGSAIKSIF SVERNYPYYH
     DYGHTRLFLH GIVTSKYFDL AIAAVIGINV ISMAMEFYMM PMGLKYVLKA LNYFFTAVFT
     LEAAMKLIAL GFKRFFIEKW NRLDMFIVIL SIAGIIFEEF EALELPINPT IIRVMRVLRI
     ARVLKLLKMA KGIRSLLDTV GEALPQVGNL GSLFFLLFFI FAALGVELFG KLECSEDHPC
     DGLGEHAHFK NFGMAFLTLF RIATGDNWNG IMKDALRDDC DSSDHCETNC CVDPILAPCF
     FVIFVLISQF VLVNVVVAVL MKHLEESNKR DAEGPAEPTG ENIENEITKS DDDEIVEEHE
     PLAIEHVKEG ELDEEEETEE GPTTQIPDGH GGIKRLSMQV LEQELIEVER HLEERYRRAS
     ECLGGELQPL NPGEIEDLDD PEFRPRSRSH RPRARTNSAL SNKSRGSHKS AL
//
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