ID Q7ZF30_9HIV1 Unreviewed; 255 AA.
AC Q7ZF30;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:AAP22823.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAP22823.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAP22823.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAP22823.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14601592; DOI=10.1089/088922203322493111;
RA Lan N.T., Recordon-Pinson P., Hung P.V., Uyen N.T., Lien T.T., Tien H.T.,
RA Garrigue I., Schrive M.H., Pellegrin I., Lafon M.E., Aboulker J.P.,
RA Barre-Sinousi F., Fleury H.J.;
RT "HIV type 1 isolates from 200 untreated individuals in Ho Chi Minh City
RT (Vietnam): ANRS 1257 Study. Large predominance of CRF01_AE and presence of
RT major resistance mutations to antiretroviral drugs.";
RL AIDS Res. Hum. Retroviruses 19:925-928(2003).
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DR EMBL; AY238047; AAP22823.1; -; Genomic_DNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW ECO:0000313|EMBL:AAP22823.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 44..234
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAP22823.1"
FT NON_TER 255
FT /evidence="ECO:0000313|EMBL:AAP22823.1"
SQ SEQUENCE 255 AA; 29671 MW; 597EB922404FFF85 CRC64;
PISPIETVPV KLKPGMDGPK VKQWPLTEEK IKALTEICKE MEEEGKISKI GPENPYNTPV
FAIKKKDSTK WRKLVDFREL NKRTQDFWEV QLGIPHPAGL KQKKSVTVLD VGDAYFSVPL
DESFRKYTAF TIPSINNETP GIRYQYNVLP QGWKGSPAIF QCSMTKILEP FRRKNPEMVI
YQYMDDLYVG SDLEIGQHRI KIEELRAHLL SWGFTTPDKK HQKEPPFLWM GYELHPDRWT
VQPIELPEKD SWTVN
//
