ID Q7ZSY9_TAKRU Unreviewed; 300 AA.
AC Q7ZSY9; H2VBF5;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 24-JAN-2024, entry version 119.
DE RecName: Full=Melanocyte-stimulating hormone receptor {ECO:0000256|ARBA:ARBA00020454, ECO:0000256|RuleBase:RU361244};
DE Short=MSH-R {ECO:0000256|RuleBase:RU361244};
DE AltName: Full=Melanocortin receptor 1 {ECO:0000256|ARBA:ARBA00031491, ECO:0000256|RuleBase:RU361244};
GN Name=MC1R {ECO:0000313|EMBL:AAO24749.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|EMBL:AAO24749.1};
RN [1] {ECO:0000313|EMBL:AAO24749.1}
RP NUCLEOTIDE SEQUENCE.
RA Logan D.W., Bryson-Richardson R.J., Pagan K.E., Taylor M.S., Currie P.D.,
RA Jackson I.J.;
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAO65548.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14694081; DOI=10.1093/molbev/msh050;
RA Klovins J., Haitina T., Fridmanis D., Kilianova Z., Kapa I.,
RA Fredriksson R., Gallo-Payet N., Schioth H.B.;
RT "The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene
RT repertoire and synteny, as well as pharmacology and anatomical distribution
RT of the MCRs.";
RL Mol. Biol. Evol. 21:563-579(2004).
RN [3] {ECO:0000313|EMBL:BAG38415.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Muscle {ECO:0000313|EMBL:BAG38415.1};
RA Reza M.S., Furukawa S., Mochizuki T., Matsumura H., Watabe S.;
RT "Genetic comparison between torafugu Takifugu rubripes and its closely
RT related species karasu Takifugu chinensis.";
RL Fish. Sci. 74:743-754(2008).
CC -!- FUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. The
CC activity of this receptor is mediated by G proteins which activate
CC adenylate cyclase. {ECO:0000256|RuleBase:RU361244}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361244}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361244}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AY161854; AAO24749.1; -; Genomic_DNA.
DR EMBL; AY227791; AAO65548.1; -; Genomic_DNA.
DR EMBL; AB437760; BAG38415.1; -; Genomic_DNA.
DR EMBL; AB437761; BAG38416.1; -; Genomic_DNA.
DR EMBL; AB437762; BAG38417.1; -; Genomic_DNA.
DR EMBL; AB437763; BAG38418.1; -; Genomic_DNA.
DR EMBL; AB437764; BAG38419.1; -; Genomic_DNA.
DR EMBL; AB437765; BAG38420.1; -; Genomic_DNA.
DR EMBL; AB437766; BAG38421.1; -; Genomic_DNA.
DR EMBL; AB437767; BAG38422.1; -; Genomic_DNA.
DR EMBL; AB437768; BAG38423.1; -; Genomic_DNA.
DR EMBL; AB437769; BAG38424.1; -; Genomic_DNA.
DR EMBL; AB437770; BAG38425.1; -; Genomic_DNA.
DR EMBL; AB437771; BAG38426.1; -; Genomic_DNA.
DR EMBL; AB437772; BAG38427.1; -; Genomic_DNA.
DR EMBL; AB437773; BAG38428.1; -; Genomic_DNA.
DR EMBL; AB437774; BAG38429.1; -; Genomic_DNA.
DR EMBL; AB437775; BAG38430.1; -; Genomic_DNA.
DR EMBL; AB437776; BAG38431.1; -; Genomic_DNA.
DR EMBL; AB437777; BAG38432.1; -; Genomic_DNA.
DR EMBL; AB437778; BAG38433.1; -; Genomic_DNA.
DR EMBL; AB437779; BAG38434.1; -; Genomic_DNA.
DR EMBL; AB437780; BAG38435.1; -; Genomic_DNA.
DR EMBL; AB437781; BAG38436.1; -; Genomic_DNA.
DR EMBL; AB437782; BAG38437.1; -; Genomic_DNA.
DR EMBL; AB437783; BAG38438.1; -; Genomic_DNA.
DR RefSeq; NP_001127927.1; NM_001134455.1.
DR AlphaFoldDB; Q7ZSY9; -.
DR STRING; 31033.ENSTRUP00000046547; -.
DR GeneID; 100187712; -.
DR KEGG; tru:100187712; -.
DR CTD; 4157; -.
DR OrthoDB; 4160596at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004980; F:melanocyte-stimulating hormone receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001671; Melcrt_ACTH_rcpt.
DR InterPro; IPR000761; MSH_rcpt.
DR PANTHER; PTHR22750; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR22750:SF2; MELANOCYTE-STIMULATING HORMONE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00534; MCRFAMILY.
DR PRINTS; PR00536; MELNOCYTESHR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU361244};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361244};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:AAO24749.1};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361244}.
FT TRANSMEM 26..45
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361244"
FT TRANSMEM 57..82
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361244"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361244"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361244"
FT TRANSMEM 169..198
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361244"
FT TRANSMEM 219..244
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361244"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361244"
FT DOMAIN 37..277
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 300 AA; 34167 MW; D7E0507B9385DE1D CRC64;
MDDNETNITN GEQNLGCVQI LIPQELFLTL GLISLVENIL VILAIMKNRN LHSPMYYFIC
CLALSDMLVS VSNVVETVFM LLNDHGLMDM YPGMLRHLDN VIDVMICSSV VSSLSFLCTI
AADRYITIFY ALRYHSIMTT PRAITIIVIV WCASIASSIL FIVYHTDNAV IVCLVTFFCI
TLVFNAVLYV HMFVLAHVHS RRIMAFHKNR RQSTSMKGAI TLTILLGVFI LCWGPFFLHL
ILILTCPTSV FCNCYFRNFN LFLILIICNS LIDPLIYAYR SQELRKTLQE LVLCSWCFGP
//
