ID Q7ZTA9_XENLA Unreviewed; 465 AA.
AC Q7ZTA9;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Putative Rho family guanine-nucleotide exchange factor {ECO:0000313|EMBL:AAM25947.1};
DE SubName: Full=Rho guanine nucleotide exchange factor 39 {ECO:0000313|RefSeq:NP_001082576.1};
GN Name=arhgef39.L {ECO:0000313|RefSeq:NP_001082576.1,
GN ECO:0000313|Xenbase:XB-GENE-6256029};
GN Synonyms=arhgef39 {ECO:0000313|RefSeq:NP_001082576.1}, xGef
GN {ECO:0000313|RefSeq:NP_001082576.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAM25947.1};
RN [1] {ECO:0000313|RefSeq:NP_001082576.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAM25947.1, ECO:0000313|RefSeq:NP_001082576.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12648498; DOI=10.1016/S0012-1606(02)00089-1;
RA Reverte C.G., Yuan L., Keady B.T., Lacza C., Attfield K.R., Mahon G.M.,
RA Freeman B., Whitehead I.P., Hake L.E.;
RT "XGef is a CPEB-interacting protein involved in Xenopus oocyte
RT maturation.";
RL Dev. Biol. 255:383-398(2003).
RN [3] {ECO:0000313|RefSeq:NP_001082576.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AY095313; AAM25947.1; -; mRNA.
DR RefSeq; NP_001082576.1; NM_001089107.1.
DR DNASU; 398581; -.
DR GeneID; 398581; -.
DR KEGG; xla:398581; -.
DR AGR; Xenbase:XB-GENE-6256029; -.
DR CTD; 398581; -.
DR Xenbase; XB-GENE-6256029; arhgef39.L.
DR OrthoDB; 4633688at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR042987; ARHGEF39.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47056; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39; 1.
DR PANTHER; PTHR47056:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 60..236
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 266..370
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 409..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 465 AA; 53271 MW; 32AAB97A73178F13 CRC64;
MSHSSPSTWE IPLPVPGEQA VCWGDPMSAP ERRTRFSPEL VEEPEERCPL EEQRERWERK
RLTTAKALIQ TERQYLEQLE LITRIYHDVF RARCGRLKIA ETGICGHIPE ILVANRLLLS
AMDLGDFGSG FENFTESLSL YKKHADSIEP TVQVLQYHTK KKKKSFMRFR KLQESRSELK
GRPLEQLLEL PLLRVLEYRH YLRDLAENSR PGASDFAKLT SALHAVSDVC QYIDTIAQDC
DNERHLRRVQ SLIKGRRVQI LIPGRRYIRE GWLSLVPQSG EEVKQRMFFL FSDVLAVTSP
CHPLHPINCH KFTCRSLYPL RECHVERVLG HTQSRGGLIS VSFAKEKLLL MSTDQTDIND
WYKCLVGAVR KFHSNSRKNT KTAPGDQLVG EVAEEAKAQA LQPKVMKRSW DGKVKEGRQA
QRCPDFMSHE ETAPKKAKIV NDRSLQSCPP ADTQEASAGW SCSLL
//
