ID Q7ZVZ0_DANRE Unreviewed; 579 AA.
AC Q7ZVZ0;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Negative elongation factor C/D {ECO:0000313|RefSeq:NP_957484.1};
DE SubName: Full=TH1-like (Drosophila) {ECO:0000313|EMBL:AAH45357.1};
GN Name=nelfcd {ECO:0000313|RefSeq:NP_957484.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-720};
GN Synonyms=th1l {ECO:0000313|RefSeq:NP_957484.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH45357.1};
RN [1] {ECO:0000313|EMBL:AAH45357.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB {ECO:0000313|EMBL:AAH45357.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AAH45357.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_957484.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_957484.1};
RX PubMed=19112533;
RA Meng S., Ryu S., Zhao B., Zhang D.Q., Driever W., McMahon D.G.;
RT "Targeting retinal dopaminergic neurons in tyrosine hydroxylase-driven
RT green fluorescent protein transgenic zebrafish.";
RL Mol. Vis. 14:2475-2483(2008).
RN [3] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_957484.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_957484.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [5] {ECO:0000313|RefSeq:NP_957484.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_957484.1};
RX PubMed=28544213;
RA Cal L., MegIas M., Cerda-Reverter J.M., Postlethwait J.H., Braasch I.,
RA Rotllant J.;
RT "BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish
RT Reveals the Evolutionary Ancestry of Dorsal-Ventral Pigment Asymmetry in
RT Fish.";
RL J. Exp. Zool. B Mol. Dev. Evol. 328:697-708(2017).
RN [6] {ECO:0000313|RefSeq:NP_957484.1}
RP IDENTIFICATION.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_957484.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NELF-D family.
CC {ECO:0000256|ARBA:ARBA00005726}.
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DR EMBL; BC045357; AAH45357.1; -; mRNA.
DR RefSeq; NP_957484.1; NM_201190.1.
DR GeneID; 394165; -.
DR KEGG; dre:394165; -.
DR AGR; ZFIN:ZDB-GENE-040426-720; -.
DR CTD; 51497; -.
DR ZFIN; ZDB-GENE-040426-720; nelfcd.
DR OrthoDB; 306548at2759; -.
DR PhylomeDB; Q7ZVZ0; -.
DR Proteomes; UP000000437; Chromosome 6.
DR GO; GO:0032021; C:NELF complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0034244; P:negative regulation of transcription elongation by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR006942; TH1.
DR PANTHER; PTHR12144:SF0; NEGATIVE ELONGATION FACTOR C_D; 1.
DR PANTHER; PTHR12144; NEGATIVE ELONGATION FACTOR D; 1.
DR Pfam; PF04858; TH1; 1.
PE 1: Evidence at protein level;
KW Elongation factor {ECO:0000313|RefSeq:NP_957484.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein biosynthesis {ECO:0000313|RefSeq:NP_957484.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q7ZVZ0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 65271 MW; 1081598ACCDD0397 CRC64;
MDEEYYSHAG EWEAQDGSME DGYGDAEADG KVQEDCLQKF SSRDYIMEPT VFNTLKSYFQ
AGGSPEHVIQ LLSENYSAVA QTVNLLAEWL IQMGVEPAQV QERVENHLKS LLIKHFDPQK
ADSIFTVEGE TPAWLEQMIA HTTWRDLFYK LAEAHPDCLM LNFTVKLISD AGYQGEITSV
STACQQLEVF SRVLRTSLAT LLDGGEQNLE KNLPEFAKMV CHGEHTYLFA QAMMSILAQE
EQGGSAMRRI GQEVQKYAHE RGHDASQITL ALGTAAAYPR ACQALGAMLS KGALNPADIT
VLFKMFSSMD PPPVELIRVP AFLDLFMQSL FKPGAKINQD HKHKYIHILA YAASVVETWK
KNKRVNINKD ELKSTSKAIE TVHNLCCNEN KGATELVAGL STLYQCIRFP VVAMGVLKWV
DWTVSEPRYF QLQTDHTPVH LALLDEISTC HQLLHPQVLQ LLIKLFETEH SQLDVMEQME
LKKTLLDRMV HLLSRGYVLP VVGYIRKCLE KLNTDISLIR YFVTEVLDVI APPYTSDFVQ
LFLPILENDS IAGTIRTEGE NDPVAEFIAH CKSNFIMMN
//
