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Database: UniProt
Entry: Q7ZW36_DANRE
LinkDB: Q7ZW36_DANRE
Original site: Q7ZW36_DANRE 
ID   Q7ZW36_DANRE            Unreviewed;       638 AA.
AC   Q7ZW36;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   31-JAN-2018, entry version 126.
DE   SubName: Full=Potassium voltage-gated channel, Shal-related subfamily, member 3 {ECO:0000313|EMBL:AAH45304.1, ECO:0000313|Ensembl:ENSDARP00000072994};
GN   Name=kcnd3 {ECO:0000313|EMBL:AAH45304.1,
GN   ECO:0000313|Ensembl:ENSDARP00000072994,
GN   ECO:0000313|ZFIN:ZDB-GENE-030131-5626};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH45304.1};
RN   [1] {ECO:0000313|EMBL:AAH45304.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB {ECO:0000313|EMBL:AAH45304.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:AAH45304.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000072994}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000072994};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000072994, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000072994,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
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DR   EMBL; BX664742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX927185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC045304; AAH45304.1; -; mRNA.
DR   RefSeq; NP_956096.1; NM_199802.1.
DR   UniGene; Dr.80257; -.
DR   STRING; 7955.ENSDARP00000105369; -.
DR   PaxDb; Q7ZW36; -.
DR   Ensembl; ENSDART00000078533; ENSDARP00000072994; ENSDARG00000056101.
DR   GeneID; 327415; -.
DR   CTD; 3752; -.
DR   ZFIN; ZDB-GENE-030131-5626; kcnd3.
DR   eggNOG; KOG4390; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00760000118846; -.
DR   HOGENOM; HOG000231013; -.
DR   HOVERGEN; HBG106687; -.
DR   OMA; GTCCTRR; -.
DR   OrthoDB; EOG091G18X0; -.
DR   TreeFam; TF313103; -.
DR   Reactome; R-DRE-1296072; Voltage gated Potassium channels.
DR   Reactome; R-DRE-5576894; Phase 1 - inactivation of fast Na+ channels.
DR   Proteomes; UP000000437; Chromosome 8.
DR   Bgee; ENSDARG00000056101; -.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IDA:ZFIN.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR   InterPro; IPR003975; K_chnl_volt-dep_Kv4.
DR   InterPro; IPR004056; K_chnl_volt-dep_Kv4.3.
DR   InterPro; IPR024587; K_chnl_volt-dep_Kv4_C.
DR   InterPro; IPR021645; Shal-type_N.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 2.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF11879; DUF3399; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF11601; Shal-type; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01518; KV43CHANNEL.
DR   PRINTS; PR01491; KVCHANNEL.
DR   PRINTS; PR01497; SHALCHANNEL.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00091688}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    638       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5011427657.
FT   TRANSMEM    180    201       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    221    241       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    253    275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    320    341       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    381    402       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       40    139       BTB. {ECO:0000259|SMART:SM00225}.
SQ   SEQUENCE   638 AA;  72053 MW;  038645FB28947F47 CRC64;
     MAAGVAAWLP FARAAAIGWM PVANLPMPVA PSNKNKRQDE LIILNVSGRR FQTWRNTLDR
     YPDTLLGSSE KEFFFNEETR EYFFDRDPDV FRSILNFYRT GKLHYPRYEC ISAYDEELAF
     FGIIPEIISD CCYEEYKDRK RENTERLMDD LEDNKDSKLP NMTFRETMWR AFENPHTSTM
     ALVFYYVTGF FIALSVITNV VETVPCGYMP NQRDVPCGER YTEAFFCMDT ACVMIFTVEY
     LMRLFAAPSR YRFMRSVMSI IDVVAILPYY IGLVMTNNED VSGAFVTLRV FRVFRIFKFS
     RHSQGLRILG YTLKSCASEL GFLLFSLTMA IIIFATVMFY AEKGSSSSKF TSIPASFWYT
     IVTMTTLGYG DMVPKTIAGK IFGSICSLSG VLVIALPVPV IVSNFSRIYH QNQRADKRKA
     QKVQKARLAR MRISKSGSST AFLHSKRNGL NQSLELTGSL EEDQQLKKTT SLLESQHHHL
     LHCLEKTTNH EFVDERLYEQ GYLQTALQNF PSQSPSLSSE EGITGTCCSR RPKKNIQPLN
     ATHTHSHTHN LQELSALHIQ CGEQQPLNTS RSSLNLMSDE SGSLNCKSSG LVTTAIISIP
     TPPSNNSRAS PDAPSPPNPE APPLLNPSST DVVKISAL
//
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