ID Q7ZW82_DANRE Unreviewed; 377 AA.
AC Q7ZW82; A0A8M1PDS2;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 153.
DE SubName: Full=Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a {ECO:0000313|EMBL:AAH49537.1, ECO:0000313|Ensembl:ENSDARP00000046297};
GN Name=gnaia {ECO:0000313|EMBL:AAH49537.1,
GN ECO:0000313|Ensembl:ENSDARP00000046297,
GN ECO:0000313|RefSeq:NP_942100.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-2229};
GN Synonyms=cb874 {ECO:0000313|RefSeq:NP_942100.1}, fc01b07
GN {ECO:0000313|RefSeq:NP_942100.1}, wu:fc01b07
GN {ECO:0000313|RefSeq:NP_942100.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH49537.1};
RN [1] {ECO:0000313|EMBL:AAH49537.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:AAH49537.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_942100.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_942100.1};
RX PubMed=19164534; DOI=10.1073/pnas.0809420106;
RA Oka Y., Saraiva L.R., Kwan Y.Y., Korsching S.I.;
RT "The fifth class of Galpha proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:1484-1489(2009).
RN [3] {ECO:0000313|RefSeq:NP_942100.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_942100.1};
RX PubMed=21242316;
RA Oka Y., Korsching S.I.;
RT "Shared and unique G alpha proteins in the zebrafish versus mammalian
RT senses of taste and smell.";
RL Chem. Senses 36:357-365(2011).
RN [4] {ECO:0000313|RefSeq:NP_942100.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_942100.1};
RX PubMed=21452212;
RA Ohmoto M., Okada S., Nakamura S., Abe K., Matsumoto I.;
RT "Mutually exclusive expression of Galphaia and Galpha14 reveals
RT diversification of taste receptor cells in zebrafish.";
RL J. Comp. Neurol. 519:1616-1629(2011).
RN [5] {ECO:0000313|RefSeq:NP_942100.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_942100.1};
RX PubMed=22038944; DOI=10.1093/chemse/bjr095;
RA Oka Y., Saraiva L.R., Korsching S.I.;
RT "Crypt neurons express a single V1R-related ora gene.";
RL Chem. Senses 37:219-227(2012).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000046297}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000046297};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [7] {ECO:0000313|RefSeq:NP_942100.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_942100.1};
RX PubMed=24180662;
RA Lagman D., Ocampo Daza D., Widmark J., Abalo X.M., Sundstrom G.,
RA Larhammar D.;
RT "The vertebrate ancestral repertoire of visual opsins, transducin alpha
RT subunits and oxytocin/vasopressin receptors was established by duplication
RT of their shared genomic region in the two rounds of early vertebrate genome
RT duplications.";
RL BMC Evol. Biol. 13:238-238(2013).
RN [8] {ECO:0000313|Ensembl:ENSDARP00000046297, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000046297};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [9] {ECO:0000313|RefSeq:NP_942100.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_942100.1};
RX PubMed=26555542;
RA Suzuki H., Nikaido M., Hagino-Yamagishi K., Okada N.;
RT "Distinct functions of two olfactory marker protein genes derived from
RT teleost-specific whole genome duplication.";
RL BMC Evol. Biol. 15:245-245(2015).
RN [10] {ECO:0000313|RefSeq:NP_942100.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_942100.1};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [11] {ECO:0000313|RefSeq:NP_942100.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_942100.1};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [12] {ECO:0000313|RefSeq:NP_942100.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_942100.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX004889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX546452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049537; AAH49537.1; -; mRNA.
DR RefSeq; NP_942100.1; NM_198805.2.
DR STRING; 7955.ENSDARP00000121492; -.
DR PaxDb; 7955-ENSDARP00000121492; -.
DR Ensembl; ENSDART00000046298.5; ENSDARP00000046297.4; ENSDARG00000109225.1.
DR Ensembl; ENSDART00000138985.3; ENSDARP00000121492.1; ENSDARG00000044760.6.
DR GeneID; 323509; -.
DR KEGG; dre:323509; -.
DR AGR; ZFIN:ZDB-GENE-030131-2229; -.
DR CTD; 323509; -.
DR ZFIN; ZDB-GENE-030131-2229; gnaia.
DR eggNOG; KOG0082; Eukaryota.
DR HOGENOM; CLU_014184_6_0_1; -.
DR OMA; QPAMEAN; -.
DR OrthoDB; 2897309at2759; -.
DR TreeFam; TF300673; -.
DR Proteomes; UP000000437; Alternate scaffold 25.
DR Proteomes; UP000000437; Chromosome 25.
DR Bgee; ENSDARG00000044760; Expressed in presomitic mesoderm and 27 other cell types or tissues.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0031821; F:G protein-coupled serotonin receptor binding; IBA:GO_Central.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001408; Gprotein_alpha_I.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF347; GUANINE NUCLEOTIDE-BINDING PROTEIN (G PROTEIN), ALPHA-INHIBITING ACTIVITY POLYPEPTIDE A; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00441; GPROTEINAI.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 1: Evidence at protein level;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q7ZW82};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..377
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015098911"
SQ SEQUENCE 377 AA; 43656 MW; 2E3C56595403E00D CRC64;
MIILYFLTLR LLKSFRSLLN FEKMGCTLSS DDKSAQERSK MIDRNLRDDG EKASREVKLL
LLGAGESGKS TIVKQMKIIH EAGYSEEECK QYRVVVYSNT IQSIIAIIRA MGRLRIDFAD
PERADDARQL FVMAGSVDEG FMTSELAGVI KRLWRDEGVR LCFHRSREYQ LNDSASYYLN
DLDRISNSSY VPTQQDVLRT RVKTTGIVET HFTFKDLHFK MFDVGGQRSE RKKWIHCFEG
VTSIIFCVSL SDYDLVLAED EEMNRMHESM KLFDSICNNK WFTDTSIILF LNKKDLFEEK
IRMSPLSICF PEYPGSDVYE EAAAYIQCQF EDLNKRKDTK EIYSHFTCAT DTKNVQFVFD
AVTDVIIKNN LKDCGLF
//
